SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		6 / 9 LEU H  63
GLY H 102
VAL H  56
ILE H  45
ILE H 113
ILE H  37
 None
 1.36A 1hpvA-3jtlH:
undetectable		 1hpvA-3jtlH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 MET H  59
LEU H  65
GLN H  69
THR H  41
ILE H  37
 None
 0.97A 1p93A-3jtlH:
undetectable		 1p93A-3jtlH:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 ALA H 125
LEU H 100
ILE H  76
GLY H 103
HIS H 109
 None
 1.06A 2yjaB-3jtlH:
undetectable		 2yjaB-3jtlH:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.26A 3mg0H-3jtlH:
28.7
3mg0I-3jtlH:
27.5		 3mg0H-3jtlH:
32.30
3mg0I-3jtlH:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		6 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
SER H 129
 None
 0.32A 3mg0K-3jtlH:
29.4
3mg0L-3jtlH:
25.7		 3mg0K-3jtlH:
27.23
3mg0L-3jtlH:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		6 / 12 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
SER H 129
 None
 0.28A 3mg0Y-3jtlH:
16.5
3mg0Z-3jtlH:
25.3		 3mg0Y-3jtlH:
27.23
3mg0Z-3jtlH:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 ALA H 125
LEU H 100
ILE H  76
GLY H 103
HIS H 109
 None
 1.02A 3q95A-3jtlH:
undetectable		 3q95A-3jtlH:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 ALA H 125
LEU H 100
ILE H  76
GLY H 103
HIS H 109
 None
 1.03A 3q95B-3jtlH:
undetectable		 3q95B-3jtlH:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 ALA H 125
LEU H 100
ILE H  76
GLY H 103
HIS H 109
 None
 1.05A 4pxmB-3jtlH:
undetectable		 4pxmB-3jtlH:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 9 THR H   1
THR H  21
LYS H  33
ILE H  45
GLY H  47
 None
 0.38A 4qvqK-3jtlH:
29.3
4qvqL-3jtlH:
25.7		 4qvqK-3jtlH:
27.70
4qvqL-3jtlH:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 9 THR H   1
THR H  21
LYS H  33
ILE H  45
GLY H  47
 None
 0.35A 4qvqY-3jtlH:
16.6
4qvqZ-3jtlH:
25.4		 4qvqY-3jtlH:
27.70
4qvqZ-3jtlH:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.31A 4qvvH-3jtlH:
27.2		 4qvvH-3jtlH:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 8 THR H   1
THR H  21
LYS H  33
GLY H  47
VAL H  49
 None
 0.42A 4qvvK-3jtlH:
29.3
4qvvL-3jtlH:
25.7		 4qvvK-3jtlH:
27.70
4qvvL-3jtlH:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.29A 4qvvV-3jtlH:
28.9		 4qvvV-3jtlH:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 8 THR H   1
THR H  21
LYS H  33
GLY H  47
VAL H  49
 None
 0.41A 4qvvY-3jtlH:
21.8
4qvvZ-3jtlH:
25.5		 4qvvY-3jtlH:
27.70
4qvvZ-3jtlH:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.31A 4qvyH-3jtlH:
27.2		 4qvyH-3jtlH:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
LYS H  33
ALA H  46
GLY H  47
ALA H  52
 None
 1.27A 4qw0V-3jtlH:
28.9
4qw0W-3jtlH:
27.4		 4qw0V-3jtlH:
31.47
4qw0W-3jtlH:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		3 / 3 MET H 146
GLU H 150
LEU H 154
 None
 0.82A 4v2oB-3jtlH:
undetectable		 4v2oB-3jtlH:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		4 / 5 ARG H 157
MET H 146
GLU H 150
LEU H 154
 None
 1.33A 4v2oA-3jtlH:
0.8
4v2oC-3jtlH:
0.8		 4v2oA-3jtlH:
17.53
4v2oC-3jtlH:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
LYS H  33
ALA H  46
GLY H  47
ALA H  52
 None
 1.30A 5bxnV-3jtlH:
29.1
5bxnW-3jtlH:
27.5		 5bxnV-3jtlH:
31.03
5bxnW-3jtlH:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.30A 5bxnV-3jtlH:
29.1
5bxnW-3jtlH:
27.5		 5bxnV-3jtlH:
31.03
5bxnW-3jtlH:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.30A 5d0xV-3jtlH:
29.0		 5d0xV-3jtlH:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 11 ALA H 125
LEU H 100
ILE H  76
GLY H 103
HIS H 109
 None
 1.11A 5dxbB-3jtlH:
undetectable		 5dxbB-3jtlH:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.28A 5l5zH-3jtlH:
27.2
5l5zI-3jtlH:
27.6		 5l5zH-3jtlH:
31.47
5l5zI-3jtlH:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.28A 5l5zV-3jtlH:
28.9
5l5zW-3jtlH:
27.6		 5l5zV-3jtlH:
31.47
5l5zW-3jtlH:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 10 THR H   1
THR H  21
LYS H  33
ALA H  46
GLY H  47
 None
 0.17A 5lf3V-3jtlH:
30.0
5lf3W-3jtlH:
27.7		 5lf3V-3jtlH:
28.75
5lf3W-3jtlH:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 12 ILE H  13
ILE H 104
GLY H 103
GLY H 102
HIS H 109
 None
 0.95A 5twjA-3jtlH:
undetectable		 5twjA-3jtlH:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 10 ALA H  52
LEU H  55
VAL H  56
LEU H  87
ILE H 113
 None
 0.68A 5v02B-3jtlH:
undetectable
5v02R-3jtlH:
undetectable		 5v02B-3jtlH:
20.30
5v02R-3jtlH:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		5 / 9 THR H 127
GLY H 128
ALA H  46
GLY H 130
GLU H  17
 None
 1.31A 5vw4A-3jtlH:
undetectable		 5vw4A-3jtlH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3jtl PROTEASOME SUBUNIT
BETA
(Thermoplasma
acidophilum) 		3 / 3 LEU H  55
ASP H  38
ILE H  76
 None
 0.62A 6dh0B-3jtlH:
undetectable		 6dh0B-3jtlH:
21.16