SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 TRP A 321
ALA A 296
VAL A 294
 None
 0.95A 1c4dA-3jtmA:
undetectable
1c4dB-3jtmA:
undetectable		 1c4dA-3jtmA:
3.50
1c4dB-3jtmA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ASP A 221
THR A 196
GLU A 154
 GOL  A 387 (-2.9A)
None
None
 0.76A 1pj7A-3jtmA:
undetectable		 1pj7A-3jtmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 SER A  95
LEU A  93
LEU A 373
VAL A 139
ILE A 108
 None
 1.33A 1uobA-3jtmA:
undetectable		 1uobA-3jtmA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 VAL A 280
SER A 306
ARG A 157
LEU A 155
 None
 0.62A 2f78B-3jtmA:
undetectable		 2f78B-3jtmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 VAL A 280
SER A 306
ARG A 157
LEU A 155
 None
 0.84A 2f8dA-3jtmA:
undetectable		 2f8dA-3jtmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ALA A 328
GLY A 304
VAL A 280
LEU A 278
GLY A 307
 None
AZI  A 385 (-3.0A)
None
GOL  A 381 ( 4.9A)
None
 1.08A 2f8lA-3jtmA:
7.0		 2f8lA-3jtmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A 114
GLY A 136
ALA A 135
LEU A 129
ILE A 108
 None
None
GOL  A 382 ( 4.3A)
None
None
 0.93A 3em3A-3jtmA:
undetectable		 3em3A-3jtmA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 GLY A 136
ALA A 135
LEU A 373
VAL A 103
ILE A 108
 None
GOL  A 382 ( 4.3A)
None
None
None
 0.89A 3em4U-3jtmA:
undetectable		 3em4U-3jtmA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 8 SER A 124
LEU A 373
ALA A 131
ALA A 132
 GOL  A 383 (-2.7A)
None
None
None
 0.98A 3ns1L-3jtmA:
undetectable		 3ns1L-3jtmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 ASP A 360
GLU A 359
GLY A 358
ASP A 370
 AZI  A 379 (-3.3A)
None
None
None
 1.18A 3w9tD-3jtmA:
undetectable		 3w9tD-3jtmA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 LEU A 352
LYS A 349
THR A 348
 None
GOL  A 386 ( 2.7A)
None
 0.62A 4lj0A-3jtmA:
undetectable		 4lj0A-3jtmA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 ALA A 131
ALA A 133
VAL A 368
LEU A 114
VAL A 139
 None
 1.39A 5eb5B-3jtmA:
undetectable		 5eb5B-3jtmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 LEU A 161
VAL A 250
ILE A 251
ALA A 296
ILE A 270
 AZI  A 385 (-4.3A)
None
None
None
None
 1.17A 5gpgA-3jtmA:
undetectable		 5gpgA-3jtmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ASN A  40
TYR A  42
CYH A  52
 None
 1.07A 5lsuB-3jtmA:
undetectable		 5lsuB-3jtmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 VAL A 293
VAL A 297
TYR A 305
GLN A 327
 None
 1.33A 5qggA-3jtmA:
undetectable		 5qggA-3jtmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 VAL A 293
VAL A 297
TYR A 305
GLN A 327
 None
 1.29A 5qgoA-3jtmA:
undetectable		 5qgoA-3jtmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 VAL A 293
VAL A 297
TYR A 305
GLN A 327
 None
 1.30A 5qgpA-3jtmA:
undetectable		 5qgpA-3jtmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 VAL A 293
VAL A 297
TYR A 305
GLN A 327
 None
 1.35A 5qgqA-3jtmA:
undetectable		 5qgqA-3jtmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 VAL A 293
VAL A 297
TYR A 305
GLN A 327
 None
 1.33A 5qhbA-3jtmA:
undetectable		 5qhbA-3jtmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 GLU A 243
HIS A 220
VAL A 238
 None
 0.82A 5trqB-3jtmA:
undetectable		 5trqB-3jtmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 MET A 329
TYR A 305
GLY A 304
GLY A 303
 None
None
AZI  A 385 (-3.0A)
AZI  A 385 (-4.7A)
 1.22A 5x7pA-3jtmA:
undetectable		 5x7pA-3jtmA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A 217
GLY A 191
VAL A 250
LEU A 278
ILE A 194
 None
None
None
GOL  A 381 ( 4.9A)
None
 1.01A 6dh6B-3jtmA:
undetectable		 6dh6B-3jtmA:
16.08