SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		5 / 9 THR A  49
VAL A 115
ILE A 120
VAL A  79
ILE A  78
 None
None
SO4  A 179 ( 4.9A)
None
None
 1.19A 1gebA-3jtwA:
undetectable		 1gebA-3jtwA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		4 / 5 TYR A 171
VAL A 158
ILE A 161
MET A  43
 None
 1.42A 1opjA-3jtwA:
undetectable		 1opjA-3jtwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		4 / 7 TYR A  44
LEU A  64
TYR A  69
MET A  52
 None
 1.19A 1tuvA-3jtwA:
undetectable		 1tuvA-3jtwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		4 / 8 GLN A 105
VAL A   5
ILE A 120
VAL A  79
 None
None
SO4  A 179 ( 4.9A)
None
 0.78A 3fi0Q-3jtwA:
undetectable		 3fi0Q-3jtwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		4 / 4 ILE A 134
ARG A  74
ILE A   6
THR A 136
 None
None
None
UNL  A 178 ( 3.8A)
 1.05A 3ia4C-3jtwA:
15.7		 3ia4C-3jtwA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		3 / 3 TYR A  71
ASP A  73
ASP A  48
 None
 0.79A 3ou7B-3jtwA:
undetectable		 3ou7B-3jtwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		4 / 5 ASP A 111
GLY A 109
ASP A  48
THR A  49
 None
 1.23A 3vqrB-3jtwA:
undetectable		 3vqrB-3jtwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3jtw DIHYDROFOLATE
REDUCTASE
(Pediococcus
pentosaceus) 		3 / 3 ARG A   3
THR A  49
ASP A  48
 None
 0.82A 5g5gA-3jtwA:
undetectable
5g5gB-3jtwA:
undetectable		 5g5gA-3jtwA:
21.19
5g5gB-3jtwA:
21.51