SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.03A 1hrkB-3jtxA:
undetectable		 1hrkB-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 LEU A 344
VAL A  32
ILE A 312
VAL A 352
ILE A 350
 None
 0.97A 1ohrB-3jtxA:
undetectable		 1ohrB-3jtxA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 11 GLY A 139
GLY A 140
ILE A 143
TYR A 132
PRO A 125
 None
 1.11A 1p91A-3jtxA:
3.1		 1p91A-3jtxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		6 / 12 GLY A 370
SER A 180
LEU A 358
GLY A 355
GLY A 368
PRO A 127
 None
 1.39A 1uakA-3jtxA:
undetectable		 1uakA-3jtxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 THR A 109
GLY A 139
THR A 136
ALA A 135
 None
 0.80A 2a1hA-3jtxA:
undetectable
2a1hB-3jtxA:
undetectable		 2a1hA-3jtxA:
21.41
2a1hB-3jtxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 8 TYR A 213
ARG A  80
GLU A 292
TYR A  82
 None
GOL  A 397 (-4.4A)
GOL  A 397 (-3.6A)
None
 1.07A 2fl5E-3jtxA:
undetectable
2fl5F-3jtxA:
undetectable		 2fl5E-3jtxA:
20.20
2fl5F-3jtxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.04A 2hrcA-3jtxA:
undetectable		 2hrcA-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 LEU A 220
LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.29A 2po7A-3jtxA:
1.3		 2po7A-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 9 LEU A 220
LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.29A 2po7B-3jtxA:
0.5		 2po7B-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 10 LEU A  34
ILE A 390
PRO A 322
SER A 325
VAL A 319
 None
 1.25A 2qd4B-3jtxA:
undetectable		 2qd4B-3jtxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 TRP A 165
GLN A 196
PHE A 201
ILE A 203
 None
 1.00A 2qmzA-3jtxA:
2.3
2qmzB-3jtxA:
2.4		 2qmzA-3jtxA:
20.60
2qmzB-3jtxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		3 / 3 LEU A 111
GLU A 142
ILE A 143
 None
 0.56A 3czhA-3jtxA:
undetectable		 3czhA-3jtxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		3 / 3 TYR A 327
TYR A 129
GLY A  37
 None
LLP  A 244 (-3.5A)
MES  A 400 (-3.9A)
 0.69A 3eteB-3jtxA:
2.3
3eteD-3jtxA:
2.2
3eteF-3jtxA:
2.3		 3eteB-3jtxA:
22.46
3eteD-3jtxA:
22.46
3eteF-3jtxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 LEU A 344
ASP A 389
ALA A 386
TYR A 394
 None
 1.20A 3rodD-3jtxA:
undetectable		 3rodD-3jtxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 5 TYR A 209
SER A 180
ASP A 206
ILE A 131
 LLP  A 244 ( 4.3A)
None
LLP  A 244 ( 2.8A)
None
 1.17A 3uj7B-3jtxA:
3.2		 3uj7B-3jtxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		3 / 3 ARG A 245
ARG A  80
ASP A 291
 None
GOL  A 397 (-4.4A)
None
 0.99A 3wipG-3jtxA:
undetectable
3wipH-3jtxA:
undetectable		 3wipG-3jtxA:
20.05
3wipH-3jtxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_2
(SUGAR KINASE PROTEIN)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 4 SER A 124
SER A 205
TYR A 132
PRO A 155
 None
 1.35A 4e3aB-3jtxA:
2.9		 4e3aB-3jtxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 LEU A 262
ALA A 226
TRP A 189
PHE A 193
PHE A 201
 None
 1.14A 4iaqA-3jtxA:
undetectable		 4iaqA-3jtxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 7 LEU A  34
PRO A 322
SER A 325
VAL A 319
 None
 1.16A 4klrA-3jtxA:
undetectable		 4klrA-3jtxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 GLY A  98
GLY A 254
LEU A 242
ALA A 102
GLU A  38
 LLP  A 244 ( 3.8A)
None
None
None
MES  A 400 (-4.1A)
 1.08A 4lg1B-3jtxA:
undetectable		 4lg1B-3jtxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 6 TRP A 165
GLN A 196
PHE A 201
ILE A 203
 None
 1.03A 4qogA-3jtxA:
undetectable
4qogB-3jtxA:
undetectable		 4qogA-3jtxA:
20.91
4qogB-3jtxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		3 / 3 ASP A 337
GLY A 335
ASP A 334
 None
 0.65A 4xdtA-3jtxA:
0.0		 4xdtA-3jtxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 ILE A  93
GLU A  92
GLY A 258
ARG A 233
CYH A 208
 None
None
None
GOL  A 398 (-3.3A)
LLP  A 244 ( 3.5A)
 1.36A 5fhzD-3jtxA:
undetectable		 5fhzD-3jtxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 6 ARG A 342
ALA A 341
PRO A 354
PHE A 357
 None
 1.39A 5odqA-3jtxA:
undetectable		 5odqA-3jtxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		6 / 12 GLY A 370
SER A 180
LEU A 358
GLY A 355
GLY A 368
PRO A 127
 None
 1.40A 5wyqB-3jtxA:
undetectable		 5wyqB-3jtxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		6 / 12 GLY A 370
SER A 180
LEU A 358
GLY A 355
GLY A 368
PRO A 127
 None
 1.40A 5zhmB-3jtxA:
undetectable		 5zhmB-3jtxA:
19.56