SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ju8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A 182
LEU A  81
VAL A  84
THR A  89
 None
 1.02A 1o76B-3ju8A:
undetectable		 1o76B-3ju8A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 451
CYH A 279
THR A 280
ILE A 428
PHE A 444
 None
NAD  A 501 ( 2.5A)
SIN  A 504 (-3.0A)
None
NAD  A 501 (-4.3A)
 1.41A 1p93D-3ju8A:
undetectable		 1p93D-3ju8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 243
TYR A 463
GLY A 451
GLY A 445
 None
 0.81A 1rukH-3ju8A:
undetectable
1rukL-3ju8A:
undetectable		 1rukH-3ju8A:
16.94
1rukL-3ju8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 309
GLY A 363
ILE A 364
THR A 306
 None
None
None
GOL  A 510 (-4.4A)
 0.74A 1t7iB-3ju8A:
undetectable		 1t7iB-3ju8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 309
GLY A 363
ILE A 364
THR A 306
 None
None
None
GOL  A 510 (-4.4A)
 0.79A 1t7jB-3ju8A:
undetectable		 1t7jB-3ju8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 296
ILE A 267
GLN A 434
ILE A 428
 None
 0.68A 2xkwA-3ju8A:
undetectable		 2xkwA-3ju8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 155
ASN A 154
ALA A 160
VAL A 167
 None
 0.76A 3a2qA-3ju8A:
undetectable		 3a2qA-3ju8A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 226
SER A 172
LYS A 170
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.3A)
NAD  A 501 (-2.7A)
 1.05A 3aocC-3ju8A:
1.2		 3aocC-3ju8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 252
LEU A 435
ALA A 394
ALA A 407
VAL A 429
 None
 1.28A 3b0wA-3ju8A:
undetectable		 3b0wA-3ju8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A 182
LEU A  81
VAL A  84
THR A  89
 None
 0.98A 3fwiA-3ju8A:
undetectable		 3fwiA-3ju8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  19
ALA A  13
THR A   4
GLY A 206
 None
None
None
NAD  A 501 ( 4.4A)
 0.87A 3ny4A-3ju8A:
undetectable		 3ny4A-3ju8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 248
GLY A 427
ALA A 406
ALA A 438
SER A 440
 None
None
None
SIN  A 504 (-3.8A)
SO4  A 503 ( 3.7A)
 1.08A 3sudA-3ju8A:
undetectable		 3sudA-3ju8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 193
PRO A 192
ARG A  63
ALA A  54
 None
None
None
SO4  A 507 ( 4.6A)
 1.13A 3twpB-3ju8A:
3.0		 3twpB-3ju8A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 278
GLU A  99
THR A  98
 SIN  A 504 (-4.2A)
None
None
 0.90A 3v4tA-3ju8A:
undetectable		 3v4tA-3ju8A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 408
ASN A 430
LEU A 435
ASN A 250
 None
 0.98A 3zqtA-3ju8A:
undetectable		 3zqtA-3ju8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  35
GLY A 201
GLY A 202
ALA A  36
HIS A   5
 None
 1.15A 4l8fB-3ju8A:
undetectable		 4l8fB-3ju8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  35
GLY A 201
GLY A 202
ALA A  36
HIS A   5
 None
 1.12A 4l8fD-3ju8A:
2.3		 4l8fD-3ju8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 171
ALA A  36
TYR A   6
ILE A 187
GLY A 190
 None
 1.22A 4l9qA-3ju8A:
undetectable		 4l9qA-3ju8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 385
LEU A 297
ILE A 364
LEU A 365
 None
 0.67A 4mghA-3ju8A:
undetectable		 4mghA-3ju8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 432
VAL A 257
THR A 266
ILE A 267
 None
 1.41A 4retA-3ju8A:
2.7		 4retA-3ju8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 432
VAL A 257
THR A 266
ILE A 267
 None
 1.41A 4retC-3ju8A:
2.8		 4retC-3ju8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  47
GLY A 194
ALA A 193
GLY A   9
 None
 0.67A 4zjzA-3ju8A:
undetectable		 4zjzA-3ju8A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 245
GLY A 202
ARG A 203
GLY A 206
 None
None
NAD  A 501 (-4.8A)
NAD  A 501 ( 4.4A)
 0.77A 5cdnC-3ju8A:
undetectable
5cdnD-3ju8A:
undetectable		 5cdnC-3ju8A:
21.61
5cdnD-3ju8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLU A 245
GLY A 202
ARG A 203
GLY A 206
 None
None
NAD  A 501 (-4.8A)
NAD  A 501 ( 4.4A)
 0.77A 5cdnT-3ju8A:
undetectable
5cdnU-3ju8A:
undetectable		 5cdnT-3ju8A:
21.61
5cdnU-3ju8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 456
ALA A 457
HIS A 156
LEU A 152
 None
None
None
SIN  A 504 (-4.8A)
 1.11A 5dzkB-3ju8A:
undetectable
5dzkP-3ju8A:
undetectable		 5dzkB-3ju8A:
17.72
5dzkP-3ju8A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 456
ALA A 457
HIS A 156
LEU A 152
 None
None
None
SIN  A 504 (-4.8A)
 1.11A 5dzkc-3ju8A:
undetectable
5dzkq-3ju8A:
undetectable		 5dzkc-3ju8A:
17.72
5dzkq-3ju8A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 456
ALA A 457
HIS A 156
LEU A 152
 None
None
None
SIN  A 504 (-4.8A)
 1.13A 5dzkg-3ju8A:
undetectable
5dzku-3ju8A:
undetectable		 5dzkg-3ju8A:
17.72
5dzku-3ju8A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 140
ASP A 216
LEU A 191
ALA A 160
PRO A 136
 None
 1.13A 5hnzB-3ju8A:
undetectable		 5hnzB-3ju8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 252
THR A 266
GLY A 408
VAL A 429
LEU A 410
 None
 1.37A 5jo9A-3ju8A:
5.1		 5jo9A-3ju8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 140
ASP A 216
LEU A 191
ALA A 160
PRO A 136
 None
 1.13A 5nd2B-3ju8A:
undetectable		 5nd2B-3ju8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 197
THR A 205
GLN A 200
GLY A  35
 None
 0.93A 5nzxA-3ju8A:
undetectable		 5nzxA-3ju8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 197
THR A 205
GLN A 200
GLY A  35
 None
 0.96A 5nzyA-3ju8A:
undetectable		 5nzyA-3ju8A:
22.00