SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3juc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PRO A  51
VAL A  63
TYR A 137
GLY A  65
LEU A  10
 PCA  A1001 (-4.1A)
None
NO3  A 154 (-4.8A)
None
PCA  A1001 (-3.7A)
 1.26A 1fkpA-3jucA:
undetectable		 1fkpA-3jucA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PRO A  51
VAL A  63
TYR A 137
GLY A  65
LEU A  10
 PCA  A1001 (-4.1A)
None
NO3  A 154 (-4.8A)
None
PCA  A1001 (-3.7A)
 1.20A 1lwcA-3jucA:
undetectable		 1lwcA-3jucA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 TYR A   7
TYR A  88
CYH A  84
TYR A 119
 PCA  A1001 (-3.6A)
PCA  A1001 (-4.6A)
None
None
 1.49A 2xz5A-3jucA:
undetectable
2xz5B-3jucA:
undetectable		 2xz5A-3jucA:
18.92
2xz5B-3jucA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A  53
VAL A 118
VAL A  63
LEU A  78
 None
 0.96A 3rgfA-3jucA:
undetectable		 3rgfA-3jucA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.16A 4c5lA-3jucA:
undetectable		 4c5lA-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.14A 4c5lB-3jucA:
undetectable		 4c5lB-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.12A 4c5lC-3jucA:
undetectable		 4c5lC-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.15A 4c5lD-3jucA:
undetectable		 4c5lD-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.17A 4c5nB-3jucA:
undetectable		 4c5nB-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.15A 4c5nD-3jucA:
undetectable		 4c5nD-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 117
SER A 120
HIS A  55
LEU A  93
 None
 1.39A 5dzka-3jucA:
undetectable
5dzko-3jucA:
undetectable		 5dzka-3jucA:
18.14
5dzko-3jucA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A   7
GLY A   8
LEU A  10
TYR A  88
TYR A 119
 PCA  A1001 (-3.6A)
PCA  A1001 (-3.1A)
PCA  A1001 (-3.7A)
PCA  A1001 (-4.6A)
None
 0.77A 5hwkA-3jucA:
6.7		 5hwkA-3jucA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A   7
GLY A   8
LEU A  10
TYR A  88
TYR A 119
 PCA  A1001 (-3.6A)
PCA  A1001 (-3.1A)
PCA  A1001 (-3.7A)
PCA  A1001 (-4.6A)
None
 0.78A 5hwkB-3jucA:
6.6		 5hwkB-3jucA:
22.22