SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 ALA A 104
GLY A 414
ALA A 105
ILE A 250
 None
 0.68A 1gtnI-3juxA:
undetectable
1gtnJ-3juxA:
undetectable		 1gtnI-3juxA:
6.31
1gtnJ-3juxA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 4 LYS A 101
ALA A 104
MET A 415
 ADP  A 873 (-3.2A)
None
None
 1.01A 1hk3A-3juxA:
3.2		 1hk3A-3juxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 LEU A 145
VAL A 119
GLY A 118
TYR A 140
 None
 1.04A 1jlfA-3juxA:
undetectable
1jlfB-3juxA:
undetectable		 1jlfA-3juxA:
21.16
1jlfB-3juxA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 7 LEU A 145
VAL A 119
GLY A 118
TYR A 140
 None
 1.00A 1lweA-3juxA:
undetectable		 1lweA-3juxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 LEU A 145
VAL A 119
GLY A 118
TYR A 140
 None
 1.04A 1s1xA-3juxA:
undetectable		 1s1xA-3juxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		6 / 12 LEU A 550
GLY A 578
LEU A 547
GLY A 548
GLY A 549
PRO A 476
 None
 1.36A 1uakA-3juxA:
undetectable		 1uakA-3juxA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 ARG A 557
PHE A 583
ILE A 463
ILE A 467
ARG A 568
 None
 1.05A 2j0dA-3juxA:
undetectable		 2j0dA-3juxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 ALA A 129
THR A 123
ALA A 249
PHE A 406
TYR A 405
 None
 1.15A 2nyrA-3juxA:
undetectable		 2nyrA-3juxA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 GLY A 548
LYS A 472
LYS A 473
GLU A 468
ILE A 467
 None
 1.10A 2plwA-3juxA:
3.3		 2plwA-3juxA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 7 VAL A 149
TYR A 213
CYH A 215
ILE A 207
 None
 1.17A 2xz5B-3juxA:
undetectable
2xz5E-3juxA:
undetectable		 2xz5B-3juxA:
13.39
2xz5E-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.16A 2xz5A-3juxA:
undetectable
2xz5C-3juxA:
undetectable		 2xz5A-3juxA:
13.39
2xz5C-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.18A 2xz5C-3juxA:
undetectable
2xz5D-3juxA:
undetectable		 2xz5C-3juxA:
13.39
2xz5D-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 7 ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.15A 2xz5D-3juxA:
undetectable
2xz5E-3juxA:
undetectable		 2xz5D-3juxA:
13.39
2xz5E-3juxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 7 TYR A 409
ARG A 407
GLY A 414
VAL A 122
 None
 0.73A 2y05A-3juxA:
2.2
2y05B-3juxA:
undetectable		 2y05A-3juxA:
18.97
2y05B-3juxA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 9 VAL A  81
ALA A 104
ILE A 250
PHE A  50
ILE A  85
 None
 1.39A 3hbbB-3juxA:
undetectable		 3hbbB-3juxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 ARG A 131
VAL A 139
THR A 106
 ADP  A 873 ( 4.6A)
None
None
 0.87A 3pwrA-3juxA:
undetectable		 3pwrA-3juxA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		6 / 12 GLY A  90
ALA A 413
GLY A  83
ILE A  85
ILE A 109
ILE A 250
 None
 1.25A 3s54A-3juxA:
undetectable		 3s54A-3juxA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		6 / 12 GLY A  90
ALA A 413
GLY A  83
ILE A  85
ILE A 109
ILE A 250
 None
 1.24A 3s54B-3juxA:
undetectable		 3s54B-3juxA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 LYS A 162
ASN A 163
ALA A 170
ALA A 196
ILE A 171
 None
 1.17A 3ut5D-3juxA:
2.2		 3ut5D-3juxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 5 LEU A 709
LEU A 731
LEU A 702
SER A 703
 None
 0.81A 3vhuA-3juxA:
undetectable		 3vhuA-3juxA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 6 GLY A  98
GLU A  99
ASP A  78
GLU A 185
 ADP  A 873 (-3.5A)
None
None
None
 1.06A 3vywC-3juxA:
2.8		 3vywC-3juxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 6 ILE A 552
LEU A 567
ARG A 573
THR A 536
 None
 1.19A 3wg7A-3juxA:
1.4
3wg7J-3juxA:
undetectable		 3wg7A-3juxA:
20.05
3wg7J-3juxA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.29A 4aftA-3juxA:
0.0
4aftB-3juxA:
0.0		 4aftA-3juxA:
13.52
4aftB-3juxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_C_QMRC301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 9 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.15A 4aftC-3juxA:
0.0
4aftD-3juxA:
0.0		 4aftC-3juxA:
13.52
4aftD-3juxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 159
ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.14A 4aftA-3juxA:
0.0
4aftE-3juxA:
0.0		 4aftA-3juxA:
13.52
4aftE-3juxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 GLU A 206
TYR A 157
SER A 156
 None
 1.01A 4at0A-3juxA:
undetectable		 4at0A-3juxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 VAL A 149
TYR A 213
CYH A 215
ILE A 207
 None
 1.17A 4bqtC-3juxA:
undetectable
4bqtD-3juxA:
undetectable		 4bqtC-3juxA:
13.52
4bqtD-3juxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 PHE A 282
VAL A 278
GLU A 274
 None
 0.81A 4fvqA-3juxA:
undetectable		 4fvqA-3juxA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 ARG A   9
LYS A   8
LYS A  12
 None
 1.06A 4k50A-3juxA:
undetectable		 4k50A-3juxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 ARG A   9
LYS A   8
LYS A  12
 None
 1.04A 4k50E-3juxA:
undetectable		 4k50E-3juxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 ARG A   9
LYS A   8
LYS A  12
 None
 1.05A 4k50I-3juxA:
undetectable		 4k50I-3juxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 5 VAL A 813
LEU A 672
ILE A 750
LEU A 753
 None
 0.87A 4mghA-3juxA:
undetectable		 4mghA-3juxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 5 GLY A 417
ILE A 437
LEU A  87
LEU A 128
 None
 0.87A 4o8fA-3juxA:
undetectable		 4o8fA-3juxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 LEU A 478
LEU A 494
VAL A 503
THR A 555
ILE A 463
 None
 1.12A 4ok1A-3juxA:
undetectable		 4ok1A-3juxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 GLU A 425
ILE A 563
ALA A 419
 None
 0.64A 4wnwB-3juxA:
undetectable		 4wnwB-3juxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 LYS A 162
ASN A 163
ALA A 170
ALA A 196
ILE A 171
 None
 1.15A 4x1iD-3juxA:
2.1		 4x1iD-3juxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 ARG A 557
ASP A 447
ASP A 449
ASP A 450
 None
 1.07A 4xqgA-3juxA:
undetectable		 4xqgA-3juxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 8 ARG A 557
ASP A 447
ASP A 449
ASP A 450
 None
 1.05A 4xqgB-3juxA:
undetectable		 4xqgB-3juxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 7 SER A 375
TYR A 374
ARG A 302
GLU A 768
 None
 1.29A 4xzkA-3juxA:
undetectable		 4xzkA-3juxA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 4 LEU A 378
ILE A 382
ARG A 302
TYR A 374
 None
 1.29A 4zzbA-3juxA:
4.7		 4zzbA-3juxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 4 LEU A 378
ILE A 382
ARG A 302
TYR A 374
 None
 1.41A 4zzcA-3juxA:
4.7		 4zzcA-3juxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 4 LEU A 378
ILE A 382
ARG A 302
TYR A 374
 None
 1.43A 4zzcB-3juxA:
4.7		 4zzcB-3juxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.12A 5ainA-3juxA:
0.0
5ainB-3juxA:
0.0		 5ainA-3juxA:
14.75
5ainB-3juxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.08A 5ainB-3juxA:
0.0
5ainC-3juxA:
0.0		 5ainB-3juxA:
14.75
5ainC-3juxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_C_QMRC1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.17A 5ainC-3juxA:
0.0
5ainD-3juxA:
0.0		 5ainC-3juxA:
14.75
5ainD-3juxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.13A 5ainD-3juxA:
0.0
5ainE-3juxA:
0.0		 5ainD-3juxA:
14.75
5ainE-3juxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 159
ILE A 207
VAL A 149
TYR A 213
CYH A 215
 None
 1.09A 5ainA-3juxA:
0.0
5ainE-3juxA:
0.0		 5ainA-3juxA:
14.75
5ainE-3juxA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 6 LYS A 346
ASP A 350
TYR A 374
LEU A 378
 None
 1.23A 5bmvB-3juxA:
2.3		 5bmvB-3juxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 9 ILE A 285
ALA A 314
ILE A 336
ALA A 338
LEU A 339
 None
 1.03A 5mvmA-3juxA:
4.7
5mvmE-3juxA:
4.8		 5mvmA-3juxA:
7.32
5mvmE-3juxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 ILE A 336
ALA A 338
LEU A 339
ILE A 285
ALA A 314
 None
 0.99A 5mvmD-3juxA:
4.8
5mvmE-3juxA:
4.4		 5mvmD-3juxA:
7.32
5mvmE-3juxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 10 VAL A 149
TYR A 213
CYH A 215
VAL A 159
ILE A 207
 None
 1.18A 5o87A-3juxA:
0.0
5o87B-3juxA:
0.0		 5o87A-3juxA:
6.95
5o87B-3juxA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 11 LEU A 143
GLY A 137
LEU A  63
THR A  71
ALA A  67
 None
 1.09A 5o96A-3juxA:
undetectable
5o96B-3juxA:
undetectable		 5o96A-3juxA:
14.93
5o96B-3juxA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		4 / 5 TYR A  14
VAL A 435
PRO A 438
ALA A  93
 None
 1.13A 5otrA-3juxA:
undetectable		 5otrA-3juxA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		6 / 12 LEU A 550
GLY A 578
LEU A 547
GLY A 548
GLY A 549
PRO A 476
 None
 1.30A 5wyqB-3juxA:
undetectable		 5wyqB-3juxA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		6 / 12 LEU A 550
GLY A 578
LEU A 547
GLY A 548
GLY A 549
PRO A 476
 None
 1.33A 5zhmB-3juxA:
undetectable		 5zhmB-3juxA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		3 / 3 ARG A  75
LYS A 441
ARG A  29
 None
 1.30A 6az3C-3juxA:
0.4
6az3L-3juxA:
undetectable
6az3M-3juxA:
undetectable		 6az3C-3juxA:
6.87
6az3L-3juxA:
7.39
6az3M-3juxA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3jux PROTEIN TRANSLOCASE
SUBUNIT SECA
(Thermotoga
maritima) 		5 / 12 GLY A 414
LEU A  87
GLY A  90
ASP A 260
ILE A 259
 None
 1.05A 6mhtA-3juxA:
undetectable		 6mhtA-3juxA:
18.75