SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  60
SER A 132
MET A 133
LEU A 158
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-1.2A)
None
F4P  A 314 (-4.8A)
F4P  A 314 (-4.3A)
 0.84A 1a8uA-3jweA:
25.3		 1a8uA-3jweA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		6 / 12 GLN A 245
GLY A 130
VAL A 159
LEU A 158
GLY A 135
GLY A 134
 None
None
None
F4P  A 314 (-4.8A)
None
None
 1.46A 1uakA-3jweA:
2.2		 1uakA-3jweA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		6 / 12 SER A 156
GLN A 245
GLY A 130
VAL A 159
LEU A 158
GLY A 135
 None
None
None
None
F4P  A 314 (-4.8A)
None
 1.50A 1uakA-3jweA:
2.2		 1uakA-3jweA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 9 GLY A  60
ALA A  61
SER A 132
LEU A 215
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-3.6A)
F4P  A 314 (-1.2A)
F4P  A 314 ( 4.1A)
F4P  A 314 (-4.3A)
 1.37A 1y7iA-3jweA:
18.6		 1y7iA-3jweA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 271
LEU A 154
SER A 156
LEU A 281
 None
 0.99A 1ya3A-3jweA:
undetectable		 1ya3A-3jweA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 8 ASP A 207
GLU A  63
HIS A  64
HIS A 282
 None
 0.79A 2q0iA-3jweA:
undetectable		 2q0iA-3jweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  29
THR A  20
GLN A  22
GLY A  91
HIS A  64
 None
 1.28A 3g1uB-3jweA:
5.7		 3g1uB-3jweA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  29
THR A  20
GLN A  22
GLY A  91
HIS A  64
 None
 1.36A 3h9uA-3jweA:
5.7		 3h9uA-3jweA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  29
THR A  20
GLN A  22
GLY A  91
HIS A  64
 None
 1.33A 3h9uC-3jweA:
5.9		 3h9uC-3jweA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  29
THR A  20
GLN A  22
GLY A  91
HIS A  64
 None
 1.34A 3h9uD-3jweA:
6.0		 3h9uD-3jweA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 5 HIS A 113
LEU A  80
LEU A 124
ASP A  79
 None
 1.32A 4aqlA-3jweA:
2.9		 4aqlA-3jweA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 GLN A  38
ASP A 109
GLN A 112
 None
 0.88A 4aztA-3jweA:
undetectable		 4aztA-3jweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 6 GLN A  38
ASP A 109
GLN A 112
GLU A 144
 None
 1.08A 4azvA-3jweA:
2.4		 4azvA-3jweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 1.07A 4b7nA-3jweA:
undetectable		 4b7nA-3jweA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 1.11A 4cpzC-3jweA:
undetectable		 4cpzC-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 1.07A 4cpzE-3jweA:
undetectable		 4cpzE-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 1.06A 4cpzF-3jweA:
undetectable		 4cpzF-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 0.96A 4cpzG-3jweA:
undetectable		 4cpzG-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		3 / 3 ARG A  43
ARG A  73
TRP A  45
 None
 1.12A 4cpzH-3jweA:
undetectable		 4cpzH-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 138
ALA A  84
ILE A 296
LEU A  71
ILE A 155
 None
 1.04A 4kjjA-3jweA:
undetectable		 4kjjA-3jweA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 288
THR A 289
GLU A 284
GLU A 200
 None
 0.99A 4l78A-3jweA:
undetectable		 4l78A-3jweA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 7 GLU A 200
GLU A 284
TYR A 278
ARG A 196
 None
 1.17A 4mi4B-3jweA:
1.8
4mi4C-3jweA:
1.8		 4mi4B-3jweA:
23.16
4mi4C-3jweA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 200
GLU A 284
TYR A 278
ARG A 196
 None
 1.17A 4mj8B-3jweA:
1.8
4mj8C-3jweA:
1.6		 4mj8B-3jweA:
21.56
4mj8C-3jweA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 144
ARG A 229
PHE A 103
HIS A 104
 None
 1.47A 4uciA-3jweA:
undetectable		 4uciA-3jweA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 219
ALA A 226
LEU A 223
GLY A 220
 None
None
F4P  A 314 ( 4.3A)
None
 0.99A 4xk8a-3jweA:
undetectable		 4xk8a-3jweA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 5 SER A 156
GLU A 284
SER A 192
ASP A 249
 None
 1.49A 5fhrA-3jweA:
undetectable		 5fhrA-3jweA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 5 SER A 156
GLU A 284
SER A 192
ASP A 249
 None
 1.49A 5fhrB-3jweA:
2.9		 5fhrB-3jweA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 11 THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
 None
 0.90A 5lf3K-3jweA:
undetectable
5lf3L-3jweA:
undetectable		 5lf3K-3jweA:
20.31
5lf3L-3jweA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 11 THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
 None
 0.91A 5lf3Y-3jweA:
undetectable
5lf3Z-3jweA:
undetectable		 5lf3Y-3jweA:
20.31
5lf3Z-3jweA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 11 THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
 None
 0.95A 5lf7K-3jweA:
undetectable
5lf7L-3jweA:
undetectable		 5lf7K-3jweA:
20.31
5lf7L-3jweA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 11 THR A 141
ALA A 142
GLY A 134
GLY A 135
ALA A 136
 None
 0.95A 5lf7Y-3jweA:
undetectable
5lf7Z-3jweA:
undetectable		 5lf7Y-3jweA:
20.31
5lf7Z-3jweA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  75
ILE A 296
ALA A 138
ILE A 137
GLY A  60
 None
None
None
None
F4P  A 314 ( 3.7A)
 1.03A 5veuB-3jweA:
undetectable		 5veuB-3jweA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 6 HIS A  59
MET A  98
VAL A  88
GLN A  38
 None
 1.25A 5xdhA-3jweA:
undetectable
5xdhC-3jweA:
undetectable		 5xdhA-3jweA:
18.67
5xdhC-3jweA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 6 GLN A  38
HIS A  59
MET A  98
VAL A  88
 None
 1.12A 5xdhA-3jweA:
undetectable
5xdhC-3jweA:
undetectable		 5xdhA-3jweA:
18.67
5xdhC-3jweA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
 None
None
None
F4P  A 314 (-1.2A)
None
 1.44A 6dlzA-3jweA:
2.5
6dlzD-3jweA:
3.7		 6dlzA-3jweA:
15.00
6dlzD-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
 None
F4P  A 314 (-1.2A)
None
None
None
 1.43A 6dlzB-3jweA:
3.7
6dlzC-3jweA:
2.5		 6dlzB-3jweA:
15.00
6dlzC-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
 None
None
None
F4P  A 314 (-1.2A)
None
 1.44A 6dm1A-3jweA:
2.5
6dm1D-3jweA:
3.5		 6dm1A-3jweA:
15.00
6dm1D-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
 None
F4P  A 314 (-1.2A)
None
None
None
 1.44A 6dm1B-3jweA:
3.9
6dm1C-3jweA:
2.4		 6dm1B-3jweA:
15.00
6dm1C-3jweA:
15.00