SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 12 GLY A 288
GLY A 290
ILE A 360
VAL A 312
SER A 313
 None
 0.99A 1sg9B-3jwjA:
12.2		 1sg9B-3jwjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 8 ASP A 311
SER A 316
GLN A 321
GLY A 292
GLY A 290
 None
 1.40A 2vinA-3jwjA:
undetectable		 2vinA-3jwjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3jwj HEN1
(Trichormus
variabilis) 		3 / 3 GLY A 290
ASP A 311
SER A 313
 None
 0.70A 3brfA-3jwjA:
undetectable		 3brfA-3jwjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 10 GLY A 342
ASP A 348
ILE A 285
GLY A 309
VAL A 362
 None
 1.02A 3oxwC-3jwjA:
undetectable		 3oxwC-3jwjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3jwj HEN1
(Trichormus
variabilis) 		4 / 7 LEU A 324
LEU A 327
ILE A 297
MET A 269
 None
 0.95A 3u5jA-3jwjA:
undetectable		 3u5jA-3jwjA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 12 GLU A 364
PHE A 374
LEU A 371
ILE A 429
ARG A 370
 None
 1.19A 4hytA-3jwjA:
2.9		 4hytA-3jwjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 12 GLU A 364
PHE A 374
LEU A 371
ILE A 429
ARG A 370
 None
 1.21A 4hytC-3jwjA:
undetectable		 4hytC-3jwjA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3jwj HEN1
(Trichormus
variabilis) 		4 / 4 ASP A 286
LEU A 295
ARG A 336
THR A 358
 None
 1.43A 4kjjA-3jwjA:
undetectable		 4kjjA-3jwjA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3jwj HEN1
(Trichormus
variabilis) 		4 / 4 ASP A 286
LEU A 295
ARG A 336
THR A 358
 None
 1.45A 4kjkA-3jwjA:
2.2		 4kjkA-3jwjA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3jwj HEN1
(Trichormus
variabilis) 		5 / 12 GLY A 288
LEU A 344
VAL A 362
HIS A 365
LEU A 366
 None
 0.72A 5ubbA-3jwjA:
14.9		 5ubbA-3jwjA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3jwj HEN1
(Trichormus
variabilis) 		6 / 12 GLY A 288
GLY A 290
ASP A 311
ILE A 360
HIS A 365
LEU A 366
 None
 0.48A 5wy0A-3jwjA:
24.0		 5wy0A-3jwjA:
36.44