SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 8 SER A  56
SER A 115
PHE A 210
ILE A 108
 None
 0.90A 1gm7A-3jwoA:
undetectable
1gm7B-3jwoA:
undetectable		 1gm7A-3jwoA:
18.03
1gm7B-3jwoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 8 LEU A 483
TYR A 486
ILE A 251
ILE A 215
 None
 0.67A 2bu8A-3jwoA:
undetectable		 2bu8A-3jwoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 8 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.62A 3b9lA-3jwoA:
undetectable		 3b9lA-3jwoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		3 / 3 ARG A 469
ILE A 359
THR A 399
 None
None
NAG  A 897 ( 4.4A)
 0.70A 3ia4D-3jwoA:
undetectable		 3ia4D-3jwoA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		3 / 3 SER A 365
ASP A 457
ASN A 462
 None
 0.89A 3lsfB-3jwoA:
undetectable
3lsfE-3jwoA:
undetectable		 3lsfB-3jwoA:
20.38
3lsfE-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		3 / 3 ASP A 457
ASN A 462
SER A 365
 None
 0.85A 3lsfB-3jwoA:
undetectable
3lsfE-3jwoA:
undetectable		 3lsfB-3jwoA:
20.38
3lsfE-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		3 / 3 ASP A 457
ASN A 462
SER A 365
 None
 0.73A 3lslA-3jwoA:
undetectable
3lslD-3jwoA:
undetectable		 3lslA-3jwoA:
20.38
3lslD-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		3 / 3 SER A 365
ASP A 457
ASN A 462
 None
 0.61A 3lslA-3jwoA:
undetectable
3lslD-3jwoA:
undetectable		 3lslA-3jwoA:
20.38
3lslD-3jwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		5 / 12 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
 None
 1.44A 4k39A-3jwoA:
undetectable		 4k39A-3jwoA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 6 ASP A  57
PRO A 214
HIS A 216
ARG A 252
 None
 0.63A 4lajA-3jwoA:
49.1
4lajB-3jwoA:
49.5		 4lajA-3jwoA:
82.19
4lajB-3jwoA:
82.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 5 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.80A 5jm4A-3jwoA:
undetectable		 5jm4A-3jwoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.82A 5jm4B-3jwoA:
undetectable		 5jm4B-3jwoA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens) 		4 / 6 PHE A 468
LEU A 452
ARG A 469
GLY A 471
 None
 1.10A 5o4yA-3jwoA:
undetectable		 5o4yA-3jwoA:
4.58