SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  79
HIS A  87
HIS A  90
ASP A 216
GLN A 217
 TYM  A 400 (-3.4A)
SO4  A 393 (-3.9A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
 1.03A 1jzsA-3jxeA:
2.9		 1jzsA-3jxeA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  87
GLY A  89
HIS A  90
ASP A 216
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.9A)
 0.67A 1pg2A-3jxeA:
10.6		 1pg2A-3jxeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  89
HIS A  90
ASP A 216
GLN A 217
VAL A 244
 TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.9A)
 0.75A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  87
GLY A  89
HIS A  90
ASP A 216
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.9A)
 1.07A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  90
ASP A 216
GLN A 217
PHE A 243
VAL A 244
 SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
None
TYM  A 400 (-3.9A)
 0.85A 1qu2A-3jxeA:
4.3		 1qu2A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 HIS A  87
GLY A  89
HIS A  90
ASP A 216
GLN A 217
VAL A 244
 SO4  A 393 (-3.9A)
TYM  A 400 (-3.6A)
SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.9A)
 1.06A 1qu3A-3jxeA:
5.7		 1qu3A-3jxeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  90
ASP A 216
GLN A 217
PHE A 243
VAL A 244
 SO4  A 393 ( 3.9A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
None
TYM  A 400 (-3.9A)
 0.95A 1qu3A-3jxeA:
5.7		 1qu3A-3jxeA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 THR A  78
GLY A  79
GLY A  81
LYS A 117
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 1.21A 2akeA-3jxeA:
43.4		 2akeA-3jxeA:
43.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
THR A 113
GLU A 116
LYS A 117
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.42A 2akeA-3jxeA:
43.4		 2akeA-3jxeA:
43.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 194
GLN A 111
TYR A  77
TRP A 221
 None
TYM  A 400 (-4.1A)
TYM  A 400 (-4.1A)
None
 1.48A 2aoxA-3jxeA:
2.3		 2aoxA-3jxeA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 0.91A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 198
GLN A 217
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.5A)
 1.08A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.25A 2azxA-3jxeA:
46.6		 2azxA-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 111
GLN A 198
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.2A)
 0.89A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  78
GLY A  79
GLY A  81
GLN A 198
GLN A 217
 TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-3.2A)
TYM  A 400 (-3.5A)
 1.07A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  77
THR A  78
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-4.6A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.26A 2azxB-3jxeA:
46.3		 2azxB-3jxeA:
37.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.77A 2bfpA-3jxeA:
undetectable		 2bfpA-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.79A 2bfpB-3jxeA:
3.5		 2bfpB-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.77A 2bfpC-3jxeA:
undetectable		 2bfpC-3jxeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 104
LEU A  65
TYR A  68
LEU A  46
 None
 0.78A 2bfpD-3jxeA:
undetectable		 2bfpD-3jxeA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		9 / 11 TYR A  77
GLY A  79
GLY A  81
GLN A 111
THR A 113
GLU A 116
GLN A 198
ILE A 211
GLN A 217
 TYM  A 400 (-4.1A)
TYM  A 400 (-3.4A)
TYM  A 400 (-3.5A)
TYM  A 400 (-4.1A)
TYM  A 400 (-3.6A)
TYM  A 400 (-2.7A)
TYM  A 400 (-3.2A)
None
TYM  A 400 (-3.5A)
 0.27A 2dr2A-3jxeA:
43.4		 2dr2A-3jxeA:
43.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A   5
TYR A  18
LEU A  21
PHE A  56
 None
 1.16A 3rqwC-3jxeA:
undetectable
3rqwD-3jxeA:
undetectable		 3rqwC-3jxeA:
20.63
3rqwD-3jxeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 PHE A 204
GLN A 101
PHE A 158
 None
 0.73A 3rv5A-3jxeA:
undetectable		 3rv5A-3jxeA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A  95
THR A  97
GLY A 144
PHE A 145
 None
 0.80A 3tzfB-3jxeA:
undetectable		 3tzfB-3jxeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 247
VAL A 276
CYH A 301
CYH A 332
 None
 1.38A 5te0A-3jxeA:
undetectable		 5te0A-3jxeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  92
LEU A 347
PHE A 346
HIS A 350
 None
 0.78A 5vkqA-3jxeA:
undetectable
5vkqB-3jxeA:
undetectable		 5vkqA-3jxeA:
12.18
5vkqB-3jxeA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  92
LEU A 347
PHE A 346
HIS A 350
 None
 0.77A 5vkqB-3jxeA:
undetectable
5vkqC-3jxeA:
undetectable		 5vkqB-3jxeA:
12.18
5vkqC-3jxeA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  92
LEU A 347
PHE A 346
HIS A 350
 None
 0.77A 5vkqC-3jxeA:
undetectable
5vkqD-3jxeA:
undetectable		 5vkqC-3jxeA:
12.18
5vkqD-3jxeA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3jxe TRYPTOPHANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  92
LEU A 347
PHE A 346
HIS A 350
 None
 0.78A 5vkqA-3jxeA:
undetectable
5vkqD-3jxeA:
undetectable		 5vkqA-3jxeA:
12.18
5vkqD-3jxeA:
12.18