SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_A_FUAA702_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3jxt	DISKS LARGE HOMOLOG 3 (Rattus norvegicus)	5 / 12	PHE A 416 SER A 430 ALA A 461 ALA A 466 HIS A 463	None ACT A 1 (-2.7A) None None None	1.29A	1q23A-3jxtA: undetectable 1q23B-3jxtA: undetectable	1q23A-3jxtA: 16.44 1q23B-3jxtA: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_D_CELD682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	3jxt	DISKS LARGE HOMOLOG 3 (Rattus norvegicus)	4 / 5	ARG A 403 LEU A 407 ILE A 418 PHE A 416	None	1.27A	3ln1D-3jxtA: undetectable	3ln1D-3jxtA: 9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_F_SAMF501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	3jxt	DISKS LARGE HOMOLOG 3 (Rattus norvegicus)	5 / 10	LEU A 458 GLY A 426 GLU A 422 GLY A 424 ALA A 466	None	1.17A	5o96E-3jxtA: undetectable 5o96F-3jxtA: undetectable	5o96E-3jxtA: 18.65 5o96F-3jxtA: 18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7P_A_SAMA501_0 (OXAC)	3jxt	DISKS LARGE HOMOLOG 3 (Rattus norvegicus)	5 / 12	GLU A 443 ALA A 438 SER A 441 PHE A 416 ASP A 448	None	1.21A	5w7pA-3jxtA: undetectable	5w7pA-3jxtA: 14.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_A_FUAA702_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","3jxt","DISKS LARGE HOMOLOG 3","Rattus norvegicus",5,"PHE A 416;SER A 430;ALA A 461;ALA A 466;HIS A 463","None;ACT A   1 (-2.7A);None;None;None","1.29A","1q23A-3jxtA:undetectable;1q23B-3jxtA:undetectable","1q23A-3jxtA:16.44;1q23B-3jxtA:16.44"],["3LN1_D_CELD682_2","PROSTAGLANDIN G\/H SYNTHASE 2","3jxt","DISKS LARGE HOMOLOG 3","Rattus norvegicus",4,"ARG A 403;LEU A 407;ILE A 418;PHE A 416","None","1.27A","3ln1D-3jxtA:undetectable","3ln1D-3jxtA:9.79"],["5O96_F_SAMF501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","3jxt","DISKS LARGE HOMOLOG 3","Rattus norvegicus",5,"LEU A 458;GLY A 426;GLU A 422;GLY A 424;ALA A 466","None","1.17A","5o96E-3jxtA:undetectable;5o96F-3jxtA:undetectable","5o96E-3jxtA:18.65;5o96F-3jxtA:18.65"],["5W7P_A_SAMA501_0","OXAC","3jxt","DISKS LARGE HOMOLOG 3","Rattus norvegicus",5,"GLU A 443;ALA A 438;SER A 441;PHE A 416;ASP A 448","None","1.21A","5w7pA-3jxtA:undetectable","5w7pA-3jxtA:14.11"]]