SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 11 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.23A 1axwB-3jxzA:
undetectable		 1axwB-3jxzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 11 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.33A 1hvyC-3jxzA:
undetectable		 1hvyC-3jxzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 9 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.40A 1i00A-3jxzA:
undetectable		 1i00A-3jxzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 9 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.35A 1i00B-3jxzA:
undetectable		 1i00B-3jxzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.28A 1jujA-3jxzA:
undetectable		 1jujA-3jxzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.28A 1jujB-3jxzA:
undetectable		 1jujB-3jxzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.28A 1jujC-3jxzA:
undetectable		 1jujC-3jxzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.29A 1jujD-3jxzA:
undetectable		 1jujD-3jxzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		3 / 3 VAL A 199
TRP A 201
VAL A 204
 None
 0.92A 2izqA-3jxzA:
undetectable
2izqB-3jxzA:
undetectable		 2izqA-3jxzA:
6.67
2izqB-3jxzA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		4 / 6 ARG A  66
PHE A  98
PRO A  97
THR A  94
 None
 1.00A 2m2oB-3jxzA:
undetectable		 2m2oB-3jxzA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		3 / 3 VAL A 104
GLU A 100
GLU A 101
 None
 0.68A 2nv4A-3jxzA:
undetectable		 2nv4A-3jxzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.26A 2tsrC-3jxzA:
undetectable		 2tsrC-3jxzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 9 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.26A 2tsrD-3jxzA:
undetectable		 2tsrD-3jxzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		3 / 3 TRP A 187
ALA A 193
VAL A 188
 None
 0.96A 3l8lA-3jxzA:
undetectable
3l8lB-3jxzA:
undetectable		 3l8lA-3jxzA:
6.67
3l8lB-3jxzA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 12 VAL A 199
ILE A 185
VAL A 188
LEU A 189
VAL A 200
 None
 1.01A 3w68C-3jxzA:
undetectable		 3w68C-3jxzA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 12 VAL A 199
ILE A 185
VAL A 188
LEU A 189
VAL A 200
 None
 0.93A 3w68D-3jxzA:
undetectable		 3w68D-3jxzA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 9 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.37A 4eb4C-3jxzA:
undetectable		 4eb4C-3jxzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 10 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.35A 4eb4D-3jxzA:
undetectable		 4eb4D-3jxzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 11 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.27A 4fogD-3jxzA:
undetectable		 4fogD-3jxzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 7 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.29A 4iqqA-3jxzA:
undetectable		 4iqqA-3jxzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 7 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.25A 4iqqC-3jxzA:
undetectable		 4iqqC-3jxzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		5 / 8 ILE A 131
ASP A 122
LEU A 125
GLY A 121
PHE A 153
 None
 1.31A 4iqqD-3jxzA:
undetectable		 4iqqD-3jxzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		4 / 4 ILE A 144
ASN A 143
ILE A 103
VAL A 112
 None
 1.01A 4uy87-3jxzA:
undetectable		 4uy87-3jxzA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD
(Bacillus
cereus) 		3 / 3 ASP A 122
ASN A  92
PHE A  98
 None
 0.51A 5dsgB-3jxzA:
undetectable		 5dsgB-3jxzA:
17.65