SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		4 / 8 THR A 243
ALA A 245
LEU A 189
VAL A 271
 None
 0.95A 1sn5C-3jy6A:
undetectable		 1sn5C-3jy6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 9 GLY A 313
ILE A 306
PRO A 147
ILE A  70
VAL A  72
 None
 1.28A 2nnhB-3jy6A:
undetectable		 2nnhB-3jy6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 12 ILE A 236
THR A 237
LEU A 260
ASN A 259
VAL A 271
 None
 1.05A 2vn0A-3jy6A:
undetectable		 2vn0A-3jy6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		4 / 7 ALA A 171
ALA A 170
ALA A 174
GLN A 294
 None
 0.67A 3a2qA-3jy6A:
undetectable		 3a2qA-3jy6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		4 / 8 GLN A 180
ILE A 206
VAL A 186
VAL A 244
 None
 0.77A 3fi0Q-3jy6A:
undetectable		 3fi0Q-3jy6A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 12 VAL A 148
PRO A 161
GLY A 126
ALA A 312
GLY A 313
 None
 0.92A 3ku1A-3jy6A:
2.4		 3ku1A-3jy6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 12 VAL A 148
PRO A 161
GLY A 126
ALA A 312
GLY A 313
 None
 0.92A 3ku1C-3jy6A:
2.4		 3ku1C-3jy6A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		3 / 3 VAL A 138
SER A 133
LEU A 116
 None
 0.53A 3n8xA-3jy6A:
undetectable		 3n8xA-3jy6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		4 / 7 LEU A 189
THR A 243
ALA A 245
VAL A 271
 None
 0.84A 4ik7A-3jy6A:
undetectable		 4ik7A-3jy6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		3 / 3 ASN A 167
ASP A 152
ASP A 278
 None
 0.82A 4obwD-3jy6A:
2.6		 4obwD-3jy6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		6 / 12 ILE A 282
ALA A 277
THR A 243
VAL A 271
LEU A 289
LEU A 232
 None
 1.34A 4qynA-3jy6A:
undetectable		 4qynA-3jy6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 12 ILE A 282
ALA A 277
THR A 243
VAL A 271
LEU A 289
 None
 1.37A 4qzuA-3jy6A:
undetectable		 4qzuA-3jy6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		6 / 12 ILE A 282
ALA A 277
THR A 243
VAL A 271
LEU A 289
LEU A 232
 None
 1.45A 4qzuC-3jy6A:
undetectable		 4qzuC-3jy6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		5 / 12 ILE A  89
LEU A 129
VAL A 151
GLN A 130
SER A 131
 None
 0.92A 5l8oB-3jy6A:
undetectable		 5l8oB-3jy6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		3 / 3 TYR A 223
SER A 221
TRP A 252
 None
 0.96A 5n8jB-3jy6A:
undetectable		 5n8jB-3jy6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		3 / 3 TYR A 223
SER A 221
TRP A 252
 None
 0.92A 5n8jA-3jy6A:
undetectable		 5n8jA-3jy6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3jy6 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Lactobacillus
brevis) 		3 / 3 TYR A 223
SER A 221
TRP A 252
 None
 0.99A 5n8jD-3jy6A:
undetectable		 5n8jD-3jy6A:
21.45