SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 ASP A  61
HIS A 102
HIS A  18
 MN  A 342 (-2.9A)
EPE  A 341 ( 3.6A)
MN  A 340 (-3.5A)
 0.68A 1oe1A-3jyfA:
undetectable		 1oe1A-3jyfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 ASP A  61
HIS A 102
HIS A  18
 MN  A 342 (-2.9A)
EPE  A 341 ( 3.6A)
MN  A 340 (-3.5A)
 0.68A 1oe3A-3jyfA:
undetectable		 1oe3A-3jyfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLU A  13
ILE A 306
ASP A 278
GLY A 274
PHE A 247
 None
 1.33A 1q8jA-3jyfA:
undetectable		 1q8jA-3jyfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 GLY A 163
ALA A 209
ASN A 126
ILE A 186
 None
 0.86A 2dtjA-3jyfA:
undetectable
2dtjB-3jyfA:
undetectable		 2dtjA-3jyfA:
21.69
2dtjB-3jyfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ILE A 238
ILE A  11
ILE A 194
ALA A 301
 None
 0.69A 2nniA-3jyfA:
undetectable		 2nniA-3jyfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 163
TYR A 161
GLY A  97
ILE A 186
ALA A 125
 None
 1.06A 2plwA-3jyfA:
undetectable		 2plwA-3jyfA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 10 MET A 272
PHE A 240
ALA A 258
LEU A 265
ALA A 270
 None
 1.25A 2wscB-3jyfA:
undetectable		 2wscB-3jyfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 ASP A  61
HIS A 102
HIS A  18
 MN  A 342 (-2.9A)
EPE  A 341 ( 3.6A)
MN  A 340 (-3.5A)
 0.69A 2xxgA-3jyfA:
undetectable		 2xxgA-3jyfA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 ASP A  61
HIS A 102
HIS A  18
 MN  A 342 (-2.9A)
EPE  A 341 ( 3.6A)
MN  A 340 (-3.5A)
 0.69A 2xxgC-3jyfA:
undetectable		 2xxgC-3jyfA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 MET A  89
GLU A 103
ASN A 101
 None
None
MN  A 342 ( 2.7A)
 1.09A 3a27A-3jyfA:
undetectable		 3a27A-3jyfA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 LEU A  99
ASN A 124
GLY A 163
VAL A 207
ILE A 186
 None
 1.41A 3h52A-3jyfA:
undetectable		 3h52A-3jyfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 10 MET A 272
PHE A 240
ALA A 258
LEU A 265
ALA A 270
 None
 1.24A 3lw5B-3jyfA:
undetectable		 3lw5B-3jyfA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 SER A 230
TYR A 227
GLY A 267
PRO A 269
 None
 1.44A 4e3aA-3jyfA:
1.9		 4e3aA-3jyfA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 9 ALA A 237
ILE A 159
GLY A 160
ILE A 162
VAL A 283
 None
 0.99A 4nptA-3jyfA:
undetectable		 4nptA-3jyfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ILE A  11
ILE A 194
ILE A 159
LEU A 285
 None
 0.75A 4o8fB-3jyfA:
undetectable		 4o8fB-3jyfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 MET A 136
PHE A 137
ALA A 116
LEU A 115
 None
 0.97A 4rkuA-3jyfA:
undetectable
4rkuJ-3jyfA:
undetectable		 4rkuA-3jyfA:
18.71
4rkuJ-3jyfA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 MET A 136
PHE A 137
ALA A 116
LEU A 115
 None
 1.09A 4xk8A-3jyfA:
undetectable		 4xk8A-3jyfA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 GLU A  13
THR A  14
HIS A 112
LEU A  99
 None
 1.30A 5axaA-3jyfA:
undetectable		 5axaA-3jyfA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 TYR A 122
GLY A 100
GLU A 103
ASP A  16
 None
None
None
MN  A 340 (-3.2A)
 1.32A 5emlA-3jyfA:
undetectable		 5emlA-3jyfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASP A  61
HIS A  18
ILE A  63
TYR A 106
 MN  A 342 (-2.9A)
MN  A 340 (-3.5A)
None
None
 1.22A 5ih0A-3jyfA:
undetectable		 5ih0A-3jyfA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 278
ILE A 306
GLU A 318
HIS A 330
GLY A  36
 None
 1.11A 5k7uA-3jyfA:
undetectable		 5k7uA-3jyfA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 ASP A  61
HIS A 210
HIS A 242
HIS A 102
 MN  A 342 (-2.9A)
MN  A 342 (-3.5A)
MN  A 342 ( 3.5A)
EPE  A 341 ( 3.6A)
 1.48A 5ncdD-3jyfA:
undetectable		 5ncdD-3jyfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASP A  61
HIS A  18
HIS A 244
HIS A 210
 MN  A 342 (-2.9A)
MN  A 340 (-3.5A)
MN  A 340 (-3.5A)
MN  A 342 (-3.5A)
 0.99A 5nelB-3jyfA:
undetectable
5nelC-3jyfA:
undetectable		 5nelB-3jyfA:
21.78
5nelC-3jyfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 LEU A 111
PHE A 104
ASP A 173
HIS A 210
 None
None
EPE  A 341 ( 4.8A)
MN  A 342 (-3.5A)
 1.17A 5om3A-3jyfA:
undetectable
5om3B-3jyfA:
undetectable		 5om3A-3jyfA:
10.87
5om3B-3jyfA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 GLY A 241
ASP A  16
MET A 275
GLN A  64
 None
MN  A 340 (-3.2A)
None
GOL  A 350 (-3.1A)
 1.26A 5ubbA-3jyfA:
undetectable		 5ubbA-3jyfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 4 ASP A 151
SER A 150
ASP A 149
HIS A 155
 None
 1.09A 5wyqB-3jyfA:
undetectable		 5wyqB-3jyfA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		5 / 11 HIS A 244
HIS A  18
HIS A 210
VAL A 165
HIS A 102
 MN  A 340 (-3.5A)
MN  A 340 (-3.5A)
MN  A 342 (-3.5A)
None
EPE  A 341 ( 3.6A)
 1.18A 5z0jA-3jyfA:
undetectable
5z0jB-3jyfA:
undetectable		 5z0jA-3jyfA:
13.27
5z0jB-3jyfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLY A 274
ASP A 251
GLY A 241
GLY A 212
 None
 0.72A 6ag0C-3jyfA:
2.5		 6ag0C-3jyfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3jyf 2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
BIFUNCTIONAL
PERIPLASMIC PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 GLN A 231
VAL A 232
ALA A 190
THR A 189
 None
 1.02A 6cduB-3jyfA:
undetectable
6cduC-3jyfA:
undetectable		 6cduB-3jyfA:
23.66
6cduC-3jyfA:
23.66