SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		3 / 3 VAL A 132
VAL A 111
TRP A 103
 None
 0.97A 1av2C-3jygA:
undetectable
1av2D-3jygA:
undetectable		 1av2C-3jygA:
8.09
1av2D-3jygA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 10 HIS A  15
HIS A  38
HIS A  40
THR A 138
GLU A 140
 ZN  A 200 (-3.5A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
None
None
 0.70A 2dttA-3jygA:
12.2
2dttC-3jygA:
12.4		 2dttA-3jygA:
23.08
2dttC-3jygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 10 HIS A  38
HIS A  40
THR A 138
GLU A 140
GLU A 168
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
None
None
ZN  A 200 ( 4.3A)
 0.84A 2dttA-3jygA:
12.2
2dttC-3jygA:
12.4		 2dttA-3jygA:
23.08
2dttC-3jygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		6 / 10 HIS A  15
HIS A  38
HIS A  40
THR A 138
GLU A 140
GLU A 168
 ZN  A 200 (-3.5A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
None
None
ZN  A 200 ( 4.3A)
 0.77A 2dttD-3jygA:
12.5
2dttF-3jygA:
12.5		 2dttD-3jygA:
23.08
2dttF-3jygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 HIS A  15
VAL A  17
HIS A  38
THR A 138
GLU A 140
 ZN  A 200 (-3.5A)
None
ZN  A 200 (-3.3A)
None
None
 0.64A 2dttD-3jygA:
12.5
2dttE-3jygA:
13.2		 2dttD-3jygA:
23.08
2dttE-3jygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 VAL A  17
HIS A  38
THR A 138
GLU A 140
GLU A 168
 None
ZN  A 200 (-3.3A)
None
None
ZN  A 200 ( 4.3A)
 0.85A 2dttD-3jygA:
12.5
2dttE-3jygA:
13.2		 2dttD-3jygA:
23.08
2dttE-3jygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		4 / 8 GLY A  39
GLY A  14
HIS A  15
ILE A  80
 None
None
ZN  A 200 (-3.5A)
None
 0.53A 3d41A-3jygA:
undetectable		 3d41A-3jygA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 9 THR A 169
HIS A  40
HIS A  38
HIS A  15
ILE A 142
 None
ZN  A 200 (-3.4A)
ZN  A 200 (-3.3A)
ZN  A 200 (-3.5A)
None
 1.06A 3hy7A-3jygA:
undetectable		 3hy7A-3jygA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		4 / 6 GLN A  20
HIS A  38
HIS A  40
HIS A  15
 None
ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
ZN  A 200 (-3.5A)
 0.93A 3nvcA-3jygA:
undetectable		 3nvcA-3jygA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		4 / 5 ILE A  80
VAL A 131
CYH A  12
HIS A  38
 None
None
None
ZN  A 200 (-3.3A)
 1.31A 4rzvA-3jygA:
undetectable		 4rzvA-3jygA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 HIS A  38
HIS A  40
GLU A 168
HIS A  15
VAL A  17
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
ZN  A 200 ( 4.3A)
ZN  A 200 (-3.5A)
None
 1.24A 4uovA-3jygA:
undetectable		 4uovA-3jygA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 HIS A  38
HIS A  40
GLU A 168
HIS A  15
VAL A  17
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
ZN  A 200 ( 4.3A)
ZN  A 200 (-3.5A)
None
 1.25A 4uovC-3jygA:
undetectable		 4uovC-3jygA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 HIS A  38
HIS A  40
GLU A 168
HIS A  15
VAL A  17
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
ZN  A 200 ( 4.3A)
ZN  A 200 (-3.5A)
None
 1.26A 5jn8B-3jygA:
undetectable		 5jn8B-3jygA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		5 / 11 HIS A  38
HIS A  40
GLU A 168
HIS A  15
VAL A  17
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.4A)
ZN  A 200 ( 4.3A)
ZN  A 200 (-3.5A)
None
 1.26A 5jncA-3jygA:
undetectable		 5jncA-3jygA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		4 / 5 ILE A 142
HIS A  15
HIS A  40
TYR A  13
 None
ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
None
 1.17A 5ocsA-3jygA:
undetectable		 5ocsA-3jygA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		4 / 5 ILE A 142
HIS A  15
HIS A  40
TYR A  13
 None
ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
None
 1.18A 5ocsC-3jygA:
undetectable		 5ocsC-3jygA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		3 / 3 HIS A  15
HIS A  40
HIS A  38
 ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
ZN  A 200 (-3.3A)
 0.59A 5zrdA-3jygA:
undetectable		 5zrdA-3jygA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3jyg UNCHARACTERIZED
PROTEIN
(Wolinella
succinogenes) 		3 / 3 HIS A  38
HIS A  15
HIS A  40
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
 0.60A 5zrdA-3jygA:
undetectable		 5zrdA-3jygA:
15.91