SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jyn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 GLU A 142
ALA A 166
PRO A 211
PHE A 146
GLY A 170
 None
 1.18A 1mjqG-3jynA:
undetectable
1mjqH-3jynA:
undetectable		 1mjqG-3jynA:
14.81
1mjqH-3jynA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 THR A  89
GLU A  64
GLY A  62
ASP A  44
ALA A 241
 None
None
None
None
NDP  A 350 (-3.7A)
 1.29A 1oltA-3jynA:
undetectable		 1oltA-3jynA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A  65
GLY A  88
GLY A  67
ALA A  94
HIS A  99
 None
 0.96A 2fk8A-3jynA:
6.9		 2fk8A-3jynA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 LEU A 323
GLY A  65
ALA A 119
ILE A 297
VAL A 294
ILE A 322
 None
 1.19A 2rkgA-3jynA:
undetectable		 2rkgA-3jynA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ARG A 263
TYR A  46
TYR A  52
LEU A  51
 NDP  A 350 (-4.1A)
None
None
None
 1.45A 4f8yC-3jynA:
2.5
4f8yD-3jynA:
3.1		 4f8yC-3jynA:
20.36
4f8yD-3jynA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ASP A 215
VAL A 128
ASN A 240
 None
 0.73A 4lmnA-3jynA:
undetectable		 4lmnA-3jynA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLN A   6
LEU A  16
GLY A  93
ALA A  94
ASN A  35
 None
 1.33A 4pclB-3jynA:
8.2		 4pclB-3jynA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 VAL A 107
ALA A 104
PHE A  79
 None
 0.79A 4w5nA-3jynA:
undetectable		 4w5nA-3jynA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ASP A 220
GLY A 218
ASP A 215
 None
 0.64A 4xdtA-3jynA:
undetectable		 4xdtA-3jynA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 LEU A 323
GLY A  65
ALA A 119
ILE A 297
VAL A 294
ILE A 322
 None
 1.22A 5e5kA-3jynA:
undetectable		 5e5kA-3jynA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 ILE A  43
GLY A  62
LEU A  61
LEU A  40
LEU A 323
 None
 1.24A 5fhzC-3jynA:
3.6		 5fhzC-3jynA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		6 / 12 LEU A 323
GLY A  65
ALA A 119
ILE A 297
VAL A 294
ILE A 322
 None
 1.19A 5t8hB-3jynA:
undetectable		 5t8hB-3jynA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 ALA A  86
LEU A 106
VAL A 107
LEU A 101
GLU A  64
 None
 0.85A 5v02B-3jynA:
undetectable
5v02R-3jynA:
undetectable		 5v02B-3jynA:
15.38
5v02R-3jynA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ARG A 316
LYS A 307
TYR A 300
 None
 1.28A 6gnaA-3jynA:
4.1		 6gnaA-3jynA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3jyn QUINONE
OXIDOREDUCTASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ARG A 316
LYS A 307
TYR A 300
 None
 1.28A 6gnbA-3jynA:
4.1		 6gnbA-3jynA:
22.69