SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 THR A  19
ILE A  10
GLY A  11
GLY A  13
THR A  41
 None
 1.08A 1nv8A-3jyoA:
6.7		 1nv8A-3jyoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A  91
THR A  88
ALA A  87
VAL A  96
 None
 0.76A 2a1hA-3jyoA:
undetectable
2a1hB-3jyoA:
undetectable		 2a1hA-3jyoA:
22.57
2a1hB-3jyoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 VAL A  96
GLY A  91
THR A  88
ALA A  87
 None
 0.77A 2a1hA-3jyoA:
undetectable
2a1hB-3jyoA:
undetectable		 2a1hA-3jyoA:
22.57
2a1hB-3jyoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 PRO A  20
ILE A  10
GLY A   8
TYR A  36
 None
 1.16A 2jkjD-3jyoA:
undetectable		 2jkjD-3jyoA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 PRO A  20
ILE A  10
GLY A   8
TYR A  36
 None
 1.16A 2jkjF-3jyoA:
undetectable		 2jkjF-3jyoA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 134
ALA A 185
LEU A 159
VAL A 138
VAL A 228
 NAD  A 377 ( 3.9A)
NAD  A 377 ( 4.4A)
NAD  A 377 (-4.2A)
NAD  A 377 (-3.8A)
NAD  A 377 (-4.5A)
 1.06A 2zulA-3jyoA:
6.8		 2zulA-3jyoA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 133
ALA A 157
ALA A 143
VAL A 142
THR A 212
 NAD  A 377 (-4.7A)
None
None
None
None
 1.14A 3czhA-3jyoA:
undetectable		 3czhA-3jyoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 134
ALA A 185
LEU A 159
VAL A 138
VAL A 228
 NAD  A 377 ( 3.9A)
NAD  A 377 ( 4.4A)
NAD  A 377 (-4.2A)
NAD  A 377 (-3.8A)
NAD  A 377 (-4.5A)
 1.06A 3dmhA-3jyoA:
6.9		 3dmhA-3jyoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A 271
LEU A 269
GLN A  30
 None
 0.56A 3hznG-3jyoA:
undetectable
3hznH-3jyoA:
undetectable		 3hznG-3jyoA:
23.13
3hznH-3jyoA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 281
PHE A 280
ILE A 256
PHE A 263
 None
 0.98A 3ko0B-3jyoA:
undetectable		 3ko0B-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 281
PHE A 280
ILE A 256
PHE A 263
 None
 0.95A 3ko0S-3jyoA:
undetectable		 3ko0S-3jyoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 106
ASN A  94
GLY A  65
ILE A  98
VAL A  76
 None
 0.98A 3ucbA-3jyoA:
undetectable		 3ucbA-3jyoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 114
HIS A 257
GLY A 117
ASN A 200
 None
 0.98A 3v3nB-3jyoA:
4.1		 3v3nB-3jyoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 114
HIS A 257
GLY A 117
ASN A 200
 None
 0.97A 3v3nC-3jyoA:
4.0		 3v3nC-3jyoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 THR A  69
ILE A  68
LYS A  73
PHE A 266
 None
 1.30A 4ac9C-3jyoA:
3.2		 4ac9C-3jyoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 THR A  69
ILE A  68
LYS A  73
PHE A 266
 None
 1.29A 4acaC-3jyoA:
undetectable		 4acaC-3jyoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 THR A  69
ILE A  68
LYS A  73
PHE A 266
 None
 1.27A 4acbC-3jyoA:
undetectable		 4acbC-3jyoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A 188
ALA A 157
VAL A 156
ALA A 213
 None
None
None
NAD  A 377 ( 4.0A)
 0.79A 4g77A-3jyoA:
undetectable		 4g77A-3jyoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A 136
GLY A 137
VAL A 138
ASP A 110
 NAD  A 377 (-3.4A)
NAD  A 377 (-3.7A)
NAD  A 377 (-3.8A)
None
 0.81A 4qvvK-3jyoA:
undetectable
4qvvL-3jyoA:
undetectable		 4qvvK-3jyoA:
21.00
4qvvL-3jyoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A 136
GLY A 137
VAL A 138
ASP A 110
 NAD  A 377 (-3.4A)
NAD  A 377 (-3.7A)
NAD  A 377 (-3.8A)
None
 0.80A 4qvvY-3jyoA:
undetectable
4qvvZ-3jyoA:
undetectable		 4qvvY-3jyoA:
21.00
4qvvZ-3jyoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 11 ALA A 125
VAL A 199
ASP A 227
GLY A 115
PHE A 114
 None
 1.28A 4xp4A-3jyoA:
undetectable		 4xp4A-3jyoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 THR A  19
HIS A  23
PHE A 266
THR A 109
 None
 1.30A 5u6mA-3jyoA:
undetectable		 5u6mA-3jyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 THR A  19
HIS A  23
PHE A 266
THR A 109
 None
 1.36A 5u6mB-3jyoA:
3.5		 5u6mB-3jyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A   9
THR A 109
ASN A 108
 None
 0.73A 6baaE-3jyoA:
undetectable		 6baaE-3jyoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A   9
THR A 109
ASN A 108
 None
 0.73A 6baaF-3jyoA:
undetectable		 6baaF-3jyoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A   9
THR A 109
ASN A 108
 None
 0.74A 6baaG-3jyoA:
undetectable		 6baaG-3jyoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A   9
THR A 109
ASN A 108
 None
 0.74A 6baaH-3jyoA:
undetectable		 6baaH-3jyoA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 THR A 267
GLN A  30
ARG A  32
ILE A   5
 None
 1.01A 6ef6A-3jyoA:
undetectable		 6ef6A-3jyoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3jyo QUINATE/SHIKIMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 HIS A 257
ARG A 277
ILE A 256
 None
 0.59A 6fgdA-3jyoA:
3.8		 6fgdA-3jyoA:
21.83