SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.16A 1d4fA-3jz4A:
2.1		 1d4fA-3jz4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.21A 1d4fC-3jz4A:
4.0		 1d4fC-3jz4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		6 / 11 LEU A 191
ALA A 195
LEU A 170
ALA A 166
LEU A  75
THR A 163
 None
 1.50A 1ictA-3jz4A:
undetectable
1ictC-3jz4A:
undetectable		 1ictA-3jz4A:
14.29
1ictC-3jz4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 6 HIS A 360
PHE A 366
ASP A 322
PRO A 329
 None
 1.36A 1ilqA-3jz4A:
undetectable
1ilqC-3jz4A:
undetectable		 1ilqA-3jz4A:
10.22
1ilqC-3jz4A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.93A 2e7fA-3jz4A:
undetectable		 2e7fA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.98A 2e7fB-3jz4A:
undetectable		 2e7fB-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.90A 2ogyA-3jz4A:
undetectable		 2ogyA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.94A 2ogyB-3jz4A:
undetectable		 2ogyB-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 LEU A 330
VAL A 289
SER A 445
PHE A 157
ASN A 156
 None
None
None
None
NAP  A 482 (-3.3A)
 1.47A 2y00A-3jz4A:
undetectable		 2y00A-3jz4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 8 ILE A  14
PRO A 180
VAL A 215
GLY A  45
 None
 0.90A 3em0B-3jz4A:
undetectable		 3em0B-3jz4A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 THR A 234
GLU A 385
HIS A 342
 None
NAP  A 482 (-3.5A)
None
 0.84A 3g1uB-3jz4A:
5.0		 3g1uB-3jz4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 11 ASP A 470
LEU A 472
ALA A 171
PHE A 118
PHE A 114
 None
 1.30A 3n23C-3jz4A:
3.1		 3n23C-3jz4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLY A 328
GLY A  98
THR A  94
LEU A 101
GLY A 318
 None
 1.07A 3sglA-3jz4A:
undetectable		 3sglA-3jz4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 ARG A 427
GLY A 429
GLU A 399
ALA A 419
ASN A 440
 None
 1.45A 3t7sC-3jz4A:
3.8		 3t7sC-3jz4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 LEU A  75
ALA A 166
MET A  82
PHE A 205
 None
 1.21A 3vasB-3jz4A:
undetectable		 3vasB-3jz4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 6 GLY A  16
TRP A  18
GLU A 193
ARG A   9
 None
 1.36A 4bqfA-3jz4A:
undetectable		 4bqfA-3jz4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 10 ILE A 436
LEU A 413
GLY A 438
GLY A 442
SER A 279
 None
 1.14A 4bwlC-3jz4A:
undetectable		 4bwlC-3jz4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 6 VAL A 448
PRO A 450
GLY A 467
GLU A 121
TYR A 466
 None
 1.36A 4dxuA-3jz4A:
undetectable		 4dxuA-3jz4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 GLY A 285
GLU A 385
THR A 386
 None
NAP  A 482 (-3.5A)
None
 0.48A 4kouA-3jz4A:
undetectable		 4kouA-3jz4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 GLY A 328
PRO A 329
GLN A 286
 None
 0.28A 4oltB-3jz4A:
undetectable		 4oltB-3jz4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 GLY A 328
PRO A 329
GLN A 286
 None
 0.14A 4qwpB-3jz4A:
undetectable		 4qwpB-3jz4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 VAL A 339
PHE A 394
CYH A 355
HIS A 360
 None
 1.30A 4rzvA-3jz4A:
undetectable		 4rzvA-3jz4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 TYR A 110
ILE A 108
PRO A 168
THR A 153
 None
 1.24A 4ze1A-3jz4A:
0.0		 4ze1A-3jz4A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 8 ALA A  55
GLY A 203
ALA A 202
GLY A  16
 None
 0.68A 4zjzA-3jz4A:
3.5		 4zjzA-3jz4A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 ALA A  26
GLY A 210
SER A 211
SER A  40
LEU A 189
 None
 1.04A 5gwxA-3jz4A:
3.3		 5gwxA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 6 ILE A  74
VAL A 204
VAL A 200
TRP A  63
 None
 0.90A 5jwaH-3jz4A:
2.5		 5jwaH-3jz4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 ASP A 270
ALA A 276
SER A 279
ARG A 303
LEU A 393
 None
 1.43A 5syfB-3jz4A:
undetectable		 5syfB-3jz4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 8 ALA A  90
THR A  94
ALA A 284
TRP A 155
 None
None
None
NAP  A 482 (-3.9A)
 0.66A 5x2tI-3jz4A:
undetectable
5x2tJ-3jz4A:
undetectable
5x2tK-3jz4A:
undetectable
5x2tL-3jz4A:
undetectable		 5x2tI-3jz4A:
17.13
5x2tJ-3jz4A:
16.70
5x2tK-3jz4A:
17.13
5x2tL-3jz4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 7 LEU A 321
LEU A 101
ALA A 104
ALA A  90
 None
 0.89A 6a7jA-3jz4A:
undetectable		 6a7jA-3jz4A:
10.83