SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 ALA A 179
GLY A 181
LEU A 172
LEU A 268
PRO A 265
 None
 1.41A 1cmcA-3jzdA:
undetectable
1cmcB-3jzdA:
undetectable		 1cmcA-3jzdA:
15.06
1cmcB-3jzdA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 11 ALA A 267
LEU A 268
LEU A 264
ILE A 199
ALA A 178
 None
 1.07A 1ha2A-3jzdA:
undetectable		 1ha2A-3jzdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 5 LEU A 158
VAL A  95
CYH A  42
ALA A  66
 None
 0.92A 1mz9D-3jzdA:
undetectable		 1mz9D-3jzdA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 4 LEU A 158
VAL A  95
CYH A  42
ALA A  66
 None
 0.82A 1mz9E-3jzdA:
undetectable		 1mz9E-3jzdA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 GLY A 235
VAL A 236
GLY A 237
MET A 238
THR A 128
 None
None
None
None
NAD  A 400 (-2.7A)
 1.09A 1pwyE-3jzdA:
undetectable		 1pwyE-3jzdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 GLY A 235
VAL A 236
GLY A 237
MET A 238
THR A 128
 None
None
None
None
NAD  A 400 (-2.7A)
 1.08A 1v3qE-3jzdA:
undetectable		 1v3qE-3jzdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.91A 1v54N-3jzdA:
2.1
1v54W-3jzdA:
undetectable		 1v54N-3jzdA:
22.15
1v54W-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.90A 1v55A-3jzdA:
2.3
1v55J-3jzdA:
undetectable		 1v55A-3jzdA:
22.15
1v55J-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.85A 1v55N-3jzdA:
2.2
1v55W-3jzdA:
undetectable		 1v55N-3jzdA:
22.15
1v55W-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 ALA A 306
THR A 261
PHE A 210
 None
 0.50A 2c6nB-3jzdA:
undetectable		 2c6nB-3jzdA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.94A 2dyrN-3jzdA:
2.2
2dyrW-3jzdA:
undetectable		 2dyrN-3jzdA:
22.15
2dyrW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.86A 2eijN-3jzdA:
2.2
2eijW-3jzdA:
undetectable		 2eijN-3jzdA:
22.15
2eijW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.85A 2eikN-3jzdA:
undetectable
2eikW-3jzdA:
undetectable		 2eikN-3jzdA:
22.15
2eikW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.86A 2eilN-3jzdA:
2.3
2eilW-3jzdA:
undetectable		 2eilN-3jzdA:
22.15
2eilW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.92A 2einA-3jzdA:
undetectable
2einJ-3jzdA:
undetectable		 2einA-3jzdA:
22.15
2einJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 ALA A 178
ALA A 176
GLY A 198
ILE A 199
LEU A 223
 None
 0.91A 2x1lB-3jzdA:
undetectable		 2x1lB-3jzdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.92A 3abkA-3jzdA:
1.9
3abkJ-3jzdA:
undetectable		 3abkA-3jzdA:
22.15
3abkJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 1.06A 3ablA-3jzdA:
2.2
3ablJ-3jzdA:
undetectable		 3ablA-3jzdA:
22.15
3ablJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.86A 3abmN-3jzdA:
undetectable
3abmW-3jzdA:
undetectable		 3abmN-3jzdA:
22.15
3abmW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 PRO A 149
LEU A 148
ARG A 143
 None
 0.92A 3aqiA-3jzdA:
4.0		 3aqiA-3jzdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 PRO A 149
LEU A 148
ARG A 143
 None
 0.74A 3aqiB-3jzdA:
undetectable		 3aqiB-3jzdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.89A 3asnN-3jzdA:
2.2
3asnW-3jzdA:
undetectable		 3asnN-3jzdA:
22.15
3asnW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.87A 3asoN-3jzdA:
undetectable
3asoW-3jzdA:
undetectable		 3asoN-3jzdA:
22.15
3asoW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		6 / 11 CYH A 222
LEU A 223
LEU A 202
ALA A 226
ASN A 173
VAL A 209
 None
None
None
None
NAD  A 400 ( 4.8A)
None
 1.39A 3e22B-3jzdA:
3.4		 3e22B-3jzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		6 / 11 CYH A 222
LEU A 223
LEU A 202
ALA A 226
ASN A 173
VAL A 209
 None
None
None
None
NAD  A 400 ( 4.8A)
None
 1.41A 3e22D-3jzdA:
2.9		 3e22D-3jzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 4 GLY A 230
VAL A 127
GLY A  98
THR A 100
 None
None
NAD  A 400 (-3.1A)
None
 0.77A 3ib2A-3jzdA:
undetectable		 3ib2A-3jzdA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 5 TYR A 224
PRO A 156
THR A 120
THR A 231
 None
None
NAD  A 400 (-3.8A)
None
 1.38A 3q07A-3jzdA:
undetectable		 3q07A-3jzdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 5 TYR A 224
PRO A 156
THR A 120
THR A 231
 None
None
NAD  A 400 (-3.8A)
None
 1.34A 3q07B-3jzdA:
undetectable		 3q07B-3jzdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 7 ASN A 271
PRO A 335
TYR A 332
ARG A 185
ALA A 239
 None
 1.30A 3twpA-3jzdA:
undetectable		 3twpA-3jzdA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 5 ASN A 271
PRO A 335
TYR A 332
ALA A 239
 None
 1.23A 3twpD-3jzdA:
undetectable		 3twpD-3jzdA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 LEU A  41
ALA A 108
THR A 111
ALA A  80
THR A  81
 None
 1.08A 4fiaA-3jzdA:
undetectable		 4fiaA-3jzdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 LEU A  41
ALA A 108
THR A 111
ALA A  80
THR A  81
 None
 1.08A 4fiaA-3jzdA:
undetectable		 4fiaA-3jzdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 VAL A 354
ALA A 309
PHE A 298
 None
 0.70A 4olbA-3jzdA:
3.4		 4olbA-3jzdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 ALA A 257
GLY A 124
GLN A  46
GLY A  96
LEU A 162
 NAD  A 400 ( 4.3A)
None
NAD  A 400 (-3.3A)
None
NAD  A 400 (-3.6A)
 0.89A 4uilH-3jzdA:
undetectable
4uilL-3jzdA:
undetectable		 4uilH-3jzdA:
20.94
4uilL-3jzdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 VAL A 354
ALA A 309
PHE A 298
 None
 0.70A 4w5nA-3jzdA:
3.1		 4w5nA-3jzdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		6 / 12 CYH A 222
LEU A 223
LEU A 202
ALA A 226
ASN A 173
VAL A 209
 None
None
None
None
NAD  A 400 ( 4.8A)
None
 1.34A 4x1yB-3jzdA:
3.0		 4x1yB-3jzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 VAL A 354
ALA A 309
PHE A 298
 None
 0.71A 4z4iA-3jzdA:
3.4		 4z4iA-3jzdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.87A 5b1bA-3jzdA:
undetectable
5b1bJ-3jzdA:
undetectable		 5b1bA-3jzdA:
22.15
5b1bJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 6 SER A 330
ARG A 143
GLY A 142
THR A 128
 None
None
None
NAD  A 400 (-2.7A)
 1.08A 5btaA-3jzdA:
undetectable
5btaB-3jzdA:
2.4
5btaC-3jzdA:
undetectable		 5btaA-3jzdA:
22.24
5btaB-3jzdA:
21.04
5btaC-3jzdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 6 SER A 330
ARG A 143
GLY A 142
THR A 128
 None
None
None
NAD  A 400 (-2.7A)
 1.10A 5btcA-3jzdA:
undetectable
5btcB-3jzdA:
2.4
5btcC-3jzdA:
undetectable		 5btcA-3jzdA:
22.24
5btcB-3jzdA:
21.04
5btcC-3jzdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 GLY A 249
LEU A 166
GLY A  96
THR A 100
HIS A  71
 None
None
None
None
NAD  A 400 (-3.4A)
 1.24A 5fsaB-3jzdA:
undetectable		 5fsaB-3jzdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 HIS A 177
HIS A 256
HIS A 260
ALA A 176
 None
NAD  A 400 (-3.6A)
None
None
 0.91A 5i3aA-3jzdA:
undetectable		 5i3aA-3jzdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 HIS A 177
HIS A 256
HIS A 260
ALA A 176
 None
NAD  A 400 (-3.6A)
None
None
 0.89A 5i3aB-3jzdA:
undetectable		 5i3aB-3jzdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 5 HIS A 256
HIS A 260
HIS A 177
ALA A 123
 NAD  A 400 (-3.6A)
None
None
NAD  A 400 (-3.5A)
 1.34A 5i3bB-3jzdA:
undetectable		 5i3bB-3jzdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.90A 5iy5A-3jzdA:
2.3
5iy5J-3jzdA:
undetectable		 5iy5A-3jzdA:
22.15
5iy5J-3jzdA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 VAL A 354
ALA A 309
PHE A 298
 None
 0.67A 5js1A-3jzdA:
undetectable		 5js1A-3jzdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 CYH A 245
LYS A 243
HIS A 246
 None
 1.01A 5js5A-3jzdA:
2.5		 5js5A-3jzdA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.82A 5xdqA-3jzdA:
2.3
5xdqJ-3jzdA:
undetectable		 5xdqA-3jzdA:
22.15
5xdqJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.80A 5zcqN-3jzdA:
2.3
5zcqW-3jzdA:
undetectable		 5zcqN-3jzdA:
22.15
5zcqW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 ARG A 281
LYS A   4
ARG A 284
 None
 1.47A 6az3C-3jzdA:
undetectable
6az3L-3jzdA:
undetectable
6az3M-3jzdA:
undetectable		 6az3C-3jzdA:
13.13
6az3L-3jzdA:
11.82
6az3M-3jzdA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 12 LEU A 172
ILE A 175
LEU A 268
ILE A 282
ALA A 278
 None
 1.22A 6qxsD-3jzdA:
undetectable		 6qxsD-3jzdA:
24.14