SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		4 / 5 HIS A  17
HIS A 140
HIS A 178
ASP A 251
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-2.7A)
 0.61A 1e9yB-3jzeA:
18.1		 1e9yB-3jzeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 6 HIS A  17
HIS A  19
HIS A 140
HIS A 178
ASP A 251
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-2.7A)
 0.62A 1fweC-3jzeA:
5.1		 1fweC-3jzeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		3 / 3 VAL A  53
ASP A  54
GLU A  89
 None
 0.66A 2qeuA-3jzeA:
undetectable		 2qeuA-3jzeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		3 / 3 VAL A  53
ASP A  54
GLU A  89
 None
 0.65A 2qeuC-3jzeA:
undetectable		 2qeuC-3jzeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		3 / 3 GLY A  38
ASP A  14
SER A 297
 None
 0.67A 3brfA-3jzeA:
undetectable		 3brfA-3jzeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		4 / 7 LEU A 127
LEU A  81
SER A  84
THR A  51
 None
KCX  A 103 ( 3.7A)
None
None
 0.92A 3lm8A-3jzeA:
undetectable
3lm8C-3jzeA:
undetectable		 3lm8A-3jzeA:
21.45
3lm8C-3jzeA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 12 ASP A 251
HIS A  17
HIS A  19
ALA A 267
CYH A 222
 ZN  A 401 (-2.7A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
None
None
 1.11A 3r2jC-3jzeA:
undetectable		 3r2jC-3jzeA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		3 / 3 ARG A 245
ARG A 166
ASP A 190
 None
 0.97A 3wipG-3jzeA:
undetectable
3wipH-3jzeA:
undetectable		 3wipG-3jzeA:
17.96
3wipH-3jzeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		4 / 5 HIS A  17
HIS A 140
HIS A 178
ASP A 251
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-2.7A)
 0.60A 4h9mA-3jzeA:
3.3		 4h9mA-3jzeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		3 / 3 LEU A 306
PRO A 307
ARG A  60
 None
 0.75A 4klrB-3jzeA:
undetectable		 4klrB-3jzeA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 10 PHE A 243
TYR A 279
ASP A  15
ASP A  14
GLY A 300
 None
 1.35A 4qb9C-3jzeA:
undetectable		 4qb9C-3jzeA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 12 PHE A 243
TYR A 279
ASP A  15
ASP A  14
GLY A 300
 None
 1.38A 4qb9E-3jzeA:
undetectable		 4qb9E-3jzeA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 6 HIS A  17
HIS A  19
HIS A 140
HIS A 178
ASP A 251
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-2.7A)
 0.47A 4ubpC-3jzeA:
19.4		 4ubpC-3jzeA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 12 ILE A  63
VAL A  18
PHE A  73
THR A  33
THR A 100
 None
 1.30A 5bykA-3jzeA:
undetectable		 5bykA-3jzeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		4 / 4 ASP A 251
HIS A 178
HIS A 140
HIS A  19
 ZN  A 401 (-2.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.3A)
 1.45A 5ncdD-3jzeA:
3.6		 5ncdD-3jzeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		5 / 8 ASP A 251
HIS A 178
HIS A 140
PRO A 224
HIS A  19
 ZN  A 401 (-2.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
None
ZN  A 401 ( 3.3A)
 1.35A 5nekB-3jzeA:
3.5		 5nekB-3jzeA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3jze DIHYDROOROTASE
(Salmonella
enterica) 		4 / 9 PHE A 303
VAL A 175
LEU A 248
ASP A 251
 None
None
None
ZN  A 401 (-2.7A)
 0.95A 6c2mD-3jzeA:
undetectable		 6c2mD-3jzeA:
13.62