SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 8 LEU A 367
VAL A 205
TYR A 403
GLY A 393
 None
 1.07A 1jlfA-3jzjA:
undetectable
1jlfB-3jzjA:
undetectable		 1jlfA-3jzjA:
21.90
1jlfB-3jzjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 7 LEU A 367
VAL A 205
TYR A 403
GLY A 393
 None
 1.01A 1lweA-3jzjA:
undetectable		 1lweA-3jzjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		3 / 3 VAL A  52
ASP A  51
GLU A  41
 None
 0.76A 2qeuA-3jzjA:
undetectable		 2qeuA-3jzjA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 4 LYS A 159
LEU A 220
ALA A 162
LEU A 174
 None
 1.48A 2roxA-3jzjA:
undetectable		 2roxA-3jzjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 5 LEU A 367
TYR A 189
ARG A 358
TRP A 360
 None
None
ACR  A 405 (-2.5A)
None
 1.48A 2x2iD-3jzjA:
0.0		 2x2iD-3jzjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 PHE A 138
GLY A 173
ASN A 140
ALA A 247
VAL A 246
 None
 1.05A 3av6A-3jzjA:
undetectable		 3av6A-3jzjA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		3 / 3 SER A 313
GLU A 322
ASP A 341
 None
 0.83A 3dmhA-3jzjA:
undetectable		 3dmhA-3jzjA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 7 LYS A  67
LEU A  96
ASP A  89
SER A 293
 None
 1.37A 3dzgA-3jzjA:
undetectable		 3dzgA-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 6 GLU A 357
THR A 329
ALA A 117
ALA A 116
 None
 1.25A 3ns1C-3jzjA:
1.0		 3ns1C-3jzjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		3 / 3 ARG A  81
LEU A 292
THR A 329
 ACR  A 405 (-3.0A)
None
None
 0.79A 3oxcA-3jzjA:
undetectable		 3oxcA-3jzjA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 8 TYR A 187
LEU A 158
ALA A 162
SER A 223
 None
 1.05A 3rodA-3jzjA:
undetectable		 3rodA-3jzjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 8 VAL A  52
VAL A  79
TYR A  54
TYR A 310
 None
 0.95A 3v81C-3jzjA:
undetectable		 3v81C-3jzjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 PHE A  24
VAL A  79
GLU A  46
TYR A 310
VAL A 128
 None
 1.35A 4a97B-3jzjA:
undetectable
4a97C-3jzjA:
undetectable		 4a97B-3jzjA:
19.42
4a97C-3jzjA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 11 ALA A 162
LEU A 144
ALA A 147
VAL A 250
LEU A 220
 None
 1.18A 4nqaA-3jzjA:
undetectable		 4nqaA-3jzjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 8 VAL A  52
VAL A  79
TYR A  54
TYR A 310
 None
 0.99A 4puoC-3jzjA:
undetectable		 4puoC-3jzjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 8 VAL A  52
VAL A  79
TYR A  54
TYR A 310
 None
 0.97A 4pwdC-3jzjA:
1.4		 4pwdC-3jzjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.12A 5kbwA-3jzjA:
undetectable		 5kbwA-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.22A 5kc0A-3jzjA:
0.0		 5kc0A-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 1.40A 5kc4A-3jzjA:
undetectable		 5kc4A-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 12 ASP A 179
GLY A 233
MET A 237
ASN A 235
ASN A 251
 None
 0.96A 5kc4E-3jzjA:
undetectable		 5kc4E-3jzjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		5 / 10 GLU A 191
GLY A 190
GLY A 282
ALA A 278
PRO A 277
 None
 0.92A 6e5zA-3jzjA:
undetectable		 6e5zA-3jzjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 4 LYS A 159
LEU A 220
ALA A 162
LEU A 174
 None
 1.41A 6gnrA-3jzjA:
undetectable		 6gnrA-3jzjA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH
(Streptomyces
glaucescens) 		4 / 4 LYS A 159
LEU A 220
ALA A 162
LEU A 174
 None
 1.40A 6gnrB-3jzjA:
undetectable		 6gnrB-3jzjA:
23.44