SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3jzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		5 / 12 CYH A1605
ILE A1568
VAL A1545
ILE A1625
LEU A1543
 None
 1.08A 1z9hD-3jzyA:
undetectable		 1z9hD-3jzyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		4 / 8 TYR A1565
ARG A1622
PHE A1609
VAL A1654
 None
 1.07A 2fl5E-3jzyA:
2.2
2fl5F-3jzyA:
undetectable		 2fl5E-3jzyA:
15.05
2fl5F-3jzyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		5 / 12 PRO A1639
GLY A1638
VAL A1656
ARG A1657
LEU A1604
 None
None
None
UNX  A   4 ( 4.1A)
None
 1.04A 3m6vB-3jzyA:
undetectable		 3m6vB-3jzyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		5 / 12 PRO A1639
GLY A1638
VAL A1656
ARG A1657
LEU A1604
 None
None
None
UNX  A   4 ( 4.1A)
None
 1.03A 3m6wA-3jzyA:
undetectable		 3m6wA-3jzyA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		4 / 6 LEU A1608
LEU A1620
PRO A1586
LEU A1584
 None
 1.03A 3q1eA-3jzyA:
2.6
3q1eC-3jzyA:
3.0		 3q1eA-3jzyA:
10.78
3q1eC-3jzyA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		4 / 6 PRO A1586
LEU A1584
LEU A1608
LEU A1620
 None
 0.98A 3q1eA-3jzyA:
2.6
3q1eC-3jzyA:
3.0		 3q1eA-3jzyA:
10.78
3q1eC-3jzyA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		5 / 12 LEU A1604
CYH A1566
THR A1577
ILE A1580
VAL A1656
 None
None
UNX  A   2 ( 4.7A)
None
None
 1.29A 3sp9A-3jzyA:
undetectable		 3sp9A-3jzyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		5 / 12 ASP A1610
ASP A1612
ASN A1563
ASP A1582
GLY A1560
 None
 1.25A 4djeB-3jzyA:
undetectable		 4djeB-3jzyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		4 / 8 GLY A1560
ASP A1610
PRO A1650
THR A1651
 None
 0.71A 4eyrB-3jzyA:
undetectable		 4eyrB-3jzyA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		3 / 3 ASP A1612
ASN A1563
ASP A1582
 None
 0.83A 5vopA-3jzyA:
undetectable		 5vopA-3jzyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		3 / 3 ASP A1612
ASN A1563
ASP A1582
 None
 0.89A 5vopB-3jzyA:
undetectable		 5vopB-3jzyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3jzy INTERSECTIN 2
(Homo
sapiens) 		3 / 3 ILE A1580
THR A1579
PRO A1586
 None
UNX  A   3 ( 3.8A)
None
 0.66A 6ncsA-3jzyA:
undetectable		 6ncsA-3jzyA:
22.61