SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 632
LEU A 295
ALA A 292
THR A 622
LEU A 629
 None
None
None
ADP  A1801 (-3.2A)
None
 1.40A 1jipA-3k0sA:
1.2		 1jipA-3k0sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 407
ASP A 364
ARG A 367
ARG A 363
TYR A 528
 None
 1.49A 1l7gA-3k0sA:
undetectable		 1l7gA-3k0sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 7 GLU A 122
PHE A 532
MET A 368
ALA A 371
 None
 1.27A 1linA-3k0sA:
undetectable		 1linA-3k0sA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 LEU A 691
VAL A 657
ARG A 625
THR A 655
 None
 1.35A 1nw3A-3k0sA:
1.8		 1nw3A-3k0sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 8 LEU A 463
GLU A 451
ILE A 475
TYR A 489
 None
 0.87A 1qvtA-3k0sA:
undetectable		 1qvtA-3k0sA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 ILE A 279
ARG A 274
LEU A 632
PRO A 314
 None
 1.22A 1s8fA-3k0sA:
undetectable
1s8fB-3k0sA:
undetectable		 1s8fA-3k0sA:
13.39
1s8fB-3k0sA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 603
SER A 604
PRO A 605
GLN A 606
GLY A 648
 None
 0.85A 1uakA-3k0sA:
undetectable		 1uakA-3k0sA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 GLN A 344
HIS A 370
ARG A 367
 None
 0.96A 1zlqA-3k0sA:
undetectable		 1zlqA-3k0sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 10 ASP A 296
SER A 293
GLY A 303
ARG A 128
THR A 290
 None
 1.48A 2b8jB-3k0sA:
undetectable		 2b8jB-3k0sA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 549
ASN A 557
VAL A 299
GLY A 337
VAL A 345
 None
 0.81A 2f80A-3k0sA:
undetectable		 2f80A-3k0sA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 7 ALA A 146
THR A 147
ALA A 134
ARG A 193
 None
 0.95A 2ql8A-3k0sA:
1.6
2ql8B-3k0sA:
undetectable		 2ql8A-3k0sA:
10.35
2ql8B-3k0sA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 PRO A 649
ILE A 650
ARG A 316
ASP A 651
 None
 1.49A 2rhmD-3k0sA:
2.1		 2rhmD-3k0sA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 7 LEU A 179
GLU A 182
LEU A 201
TYR A 145
 None
 1.25A 2w8yA-3k0sA:
undetectable		 2w8yA-3k0sA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 6 GLY A  87
THR A 118
GLU A  88
GLU A  26
 None
 1.07A 3fpjA-3k0sA:
undetectable		 3fpjA-3k0sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 ARG A 350
ASP A 364
ASP A 347
 None
 0.73A 3jayA-3k0sA:
3.6		 3jayA-3k0sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 ARG A 350
ASP A 364
ASP A 347
 None
 0.83A 3jb2A-3k0sA:
undetectable		 3jb2A-3k0sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 ARG A 350
ASP A 364
ASP A 347
 None
 0.83A 3jb3A-3k0sA:
2.7		 3jb3A-3k0sA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 11 LEU A  83
VAL A  90
ALA A  91
PHE A  40
ARG A  58
 None
 1.40A 3n23C-3k0sA:
undetectable		 3n23C-3k0sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 LEU A 555
GLN A 326
THR A 327
GLU A 551
 None
 1.48A 3n58C-3k0sA:
undetectable		 3n58C-3k0sA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 7 GLY A 142
ILE A 136
LEU A 189
PHE A 184
 None
 0.90A 4ejjD-3k0sA:
undetectable		 4ejjD-3k0sA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 407
ASP A 364
ARG A 367
ARG A 363
TYR A 528
 None
 1.48A 4mwvA-3k0sA:
undetectable		 4mwvA-3k0sA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 ILE A 503
ASP A 511
GLU A 505
VAL A 465
 None
 0.94A 4nkxC-3k0sA:
undetectable		 4nkxC-3k0sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 ILE A 503
ASP A 511
GLU A 505
VAL A 465
 None
 0.92A 4nkxD-3k0sA:
undetectable		 4nkxD-3k0sA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 SER A 151
GLU A 177
GLU A  88
 None
 0.85A 4ymgB-3k0sA:
undetectable		 4ymgB-3k0sA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 ILE A 258
ALA A 237
ALA A 244
LEU A 148
PHE A 225
 None
 0.92A 4zo1X-3k0sA:
undetectable		 4zo1X-3k0sA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 6 ILE A 412
ARG A 437
ILE A 425
GLU A 524
 None
 1.41A 4zzcB-3k0sA:
2.5
4zzcC-3k0sA:
2.5		 4zzcB-3k0sA:
17.66
4zzcC-3k0sA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 7 LEU A 283
ILE A 653
THR A 655
MET A 269
 None
 0.68A 5ljcA-3k0sA:
undetectable		 5ljcA-3k0sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 LEU A 352
ALA A 356
LEU A 536
LEU A 535
LEU A 403
 None
 1.03A 5toaA-3k0sA:
undetectable		 5toaA-3k0sA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 12 TYR A  37
ALA A  69
ALA A  47
ILE A 113
LEU A  29
 None
 1.23A 6aybA-3k0sA:
undetectable		 6aybA-3k0sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 GLU A 122
LEU A 125
ARG A 305
 None
 0.77A 6d8fA-3k0sA:
undetectable		 6d8fA-3k0sA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		4 / 5 LYS A 245
GLN A 212
GLY A 224
ILE A 258
 None
 1.34A 6debB-3k0sA:
undetectable		 6debB-3k0sA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		3 / 3 ARG A  32
PHE A  36
GLY A  34
 None
 0.70A 6fgdA-3k0sA:
undetectable		 6fgdA-3k0sA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 3k0s DNA MISMATCH REPAIR
PROTEIN MUTS
(Escherichia
coli) 		5 / 9 THR A 622
GLY A 619
GLY A 618
VAL A 775
GLU A 594
 ADP  A1801 (-3.2A)
ADP  A1801 (-3.2A)
ADP  A1801 (-3.8A)
None
None
 1.06A 6gnfA-3k0sA:
2.1		 6gnfA-3k0sA:
19.70