SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 4 LEU A 185
VAL A 286
CYH A 288
ALA A 261
 None
 1.17A 1mz9E-3k1jA:
undetectable		 1mz9E-3k1jA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 5 ASP A  91
LEU A 184
ALA A 111
LEU A  89
 None
 1.05A 1nh8A-3k1jA:
undetectable		 1nh8A-3k1jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A  53
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.92A 1xiuB-3k1jA:
undetectable		 1xiuB-3k1jA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A  53
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.90A 1xlsA-3k1jA:
undetectable		 1xlsA-3k1jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A  53
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.89A 1xlsB-3k1jA:
undetectable		 1xlsB-3k1jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A  53
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.89A 1xlsC-3k1jA:
undetectable		 1xlsC-3k1jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A  53
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.89A 1xlsD-3k1jA:
undetectable		 1xlsD-3k1jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 6 THR A 300
GLU A 246
PHE A 243
ILE A 244
 None
 1.33A 2w98B-3k1jA:
undetectable		 2w98B-3k1jA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		3 / 3 GLY A 232
GLY A 205
GLY A 209
 None
 0.40A 3bogC-3k1jA:
undetectable		 3bogC-3k1jA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		3 / 3 GLY A 232
GLY A 205
GLY A 209
 None
 0.41A 3bogD-3k1jA:
undetectable		 3bogD-3k1jA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 10 ARG A 628
ILE A 627
ILE A 495
VAL A 609
LEU A 614
 None
 1.49A 3eqmA-3k1jA:
undetectable		 3eqmA-3k1jA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 VAL A  50
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.92A 3fc6C-3k1jA:
undetectable		 3fc6C-3k1jA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		6 / 12 LEU A 446
GLY A 549
ALA A 523
ASP A 522
PRO A 458
VAL A 456
 None
 1.44A 3k4vA-3k1jA:
undetectable		 3k4vA-3k1jA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 7 LEU A  93
VAL A 109
VAL A 118
LEU A  89
ASP A 187
 None
 1.19A 3rgfA-3k1jA:
undetectable		 3rgfA-3k1jA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.85A 3ut5D-3k1jA:
undetectable		 3ut5D-3k1jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A 234
LEU A 242
ILE A 197
ALA A 199
ILE A 269
 None
 1.02A 3vrmA-3k1jA:
undetectable		 3vrmA-3k1jA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A 503
LEU A 551
VAL A 443
ILE A 627
LEU A 610
 None
 1.03A 3w67B-3k1jA:
undetectable		 3w67B-3k1jA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 ILE A 503
LEU A 551
VAL A 443
ILE A 627
LEU A 610
 None
 0.99A 3w68B-3k1jA:
undetectable		 3w68B-3k1jA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 9 ASP A 404
ALA A 392
GLY A 389
VAL A 405
VAL A 343
 None
 1.26A 4c5lB-3k1jA:
undetectable		 4c5lB-3k1jA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 10 ASP A 404
ALA A 392
GLY A 389
VAL A 405
VAL A 343
 None
 1.25A 4c5nB-3k1jA:
undetectable		 4c5nB-3k1jA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.03A 4e47A-3k1jA:
undetectable		 4e47A-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.00A 4e47B-3k1jA:
undetectable		 4e47B-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 561
GLY A 372
ASN A 584
 None
 1.26A 4e47C-3k1jA:
undetectable		 4e47C-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.08A 4e47C-3k1jA:
undetectable		 4e47C-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 9 ALA A 464
GLY A 472
ILE A 474
HIS A 509
ILE A 475
 None
 1.14A 4eatB-3k1jA:
undetectable		 4eatB-3k1jA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 614
GLU A 604
LEU A 551
THR A 530
ILE A 533
 None
 1.19A 4hytA-3k1jA:
undetectable		 4hytA-3k1jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 614
GLU A 604
LEU A 551
THR A 530
ILE A 533
 None
 1.20A 4hytC-3k1jA:
undetectable		 4hytC-3k1jA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.02A 4jdsA-3k1jA:
undetectable		 4jdsA-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.03A 4jdsB-3k1jA:
undetectable		 4jdsB-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.06A 4jdsC-3k1jA:
undetectable		 4jdsC-3k1jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 10 ARG A 628
ILE A 627
ILE A 495
VAL A 609
LEU A 614
 None
 1.36A 4kq8A-3k1jA:
undetectable		 4kq8A-3k1jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 PHE A 512
ILE A 474
ALA A 531
VAL A 488
VAL A 491
 None
 0.99A 4nkvA-3k1jA:
undetectable		 4nkvA-3k1jA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 PHE A 512
ILE A 474
ALA A 531
VAL A 488
VAL A 491
 None
 0.97A 4nkvB-3k1jA:
undetectable		 4nkvB-3k1jA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 PHE A 512
ILE A 474
ALA A 531
VAL A 488
VAL A 491
 None
 1.04A 4nkxA-3k1jA:
undetectable		 4nkxA-3k1jA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.79A 4o2bD-3k1jA:
undetectable		 4o2bD-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 6 LEU A 292
MET A 304
LEU A  64
ILE A  53
 None
 1.16A 4okxA-3k1jA:
undetectable		 4okxA-3k1jA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.85A 4x20B-3k1jA:
undetectable		 4x20B-3k1jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 GLU A 585
ASP A 587
GLU A 604
GLY A 549
ALA A 523
 None
 1.11A 4xe5A-3k1jA:
3.3		 4xe5A-3k1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 PHE A 243
GLY A 201
LEU A  65
LEU A  64
THR A 300
 None
 0.97A 4zmeA-3k1jA:
undetectable		 4zmeA-3k1jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 5 GLU A 401
LYS A 397
ASP A 404
GLU A 403
 None
 1.20A 5a06A-3k1jA:
undetectable		 5a06A-3k1jA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 11 ILE A 580
ALA A 563
GLY A 562
GLY A 372
ASN A 584
 None
 1.07A 5ayfA-3k1jA:
undetectable		 5ayfA-3k1jA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 8 ILE A 474
ALA A 487
VAL A 491
VAL A 476
 None
 0.80A 5ecnD-3k1jA:
undetectable		 5ecnD-3k1jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.81A 5eypB-3k1jA:
undetectable		 5eypB-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		3 / 3 PRO A 581
LEU A 446
SER A 550
 None
 0.68A 5fsaB-3k1jA:
undetectable		 5fsaB-3k1jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 MET A 321
THR A  71
LEU A 378
ILE A  53
GLY A  77
 None
ADP  A 642 (-4.6A)
ADP  A 642 (-3.9A)
None
None
 1.09A 5gs4A-3k1jA:
undetectable		 5gs4A-3k1jA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL6_A_ASDA601_1
(AROMATASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 9 ARG A 628
ILE A 627
ILE A 495
VAL A 609
LEU A 614
 None
 1.49A 5jl6A-3k1jA:
0.0		 5jl6A-3k1jA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL9_A_ASDA601_1
(AROMATASE)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 9 ARG A 628
ILE A 627
ILE A 495
VAL A 609
LEU A 614
 None
 1.48A 5jl9A-3k1jA:
0.0		 5jl9A-3k1jA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 8 LEU A 308
LEU A 242
MET A 233
ILE A 234
 None
 0.75A 5mzjA-3k1jA:
undetectable		 5mzjA-3k1jA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.84A 5nm5B-3k1jA:
undetectable		 5nm5B-3k1jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 8 VAL A 357
ILE A  33
GLU A  26
LEU A  23
 None
 0.75A 5og9A-3k1jA:
undetectable		 5og9A-3k1jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		4 / 5 LEU A 298
TYR A 320
MET A 321
ASP A 245
 None
 1.09A 5p9iA-3k1jA:
undetectable		 5p9iA-3k1jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 12 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.88A 5xiwB-3k1jA:
undetectable		 5xiwB-3k1jA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3k1j ATP-DEPENDENT
PROTEASE LON
(Thermococcus
onnurineus) 		5 / 10 MET A 233
GLY A 232
GLN A 272
THR A 270
THR A 283
 None
 1.31A 6nmpG-3k1jA:
0.0
6nmpN-3k1jA:
0.0
6nmpO-3k1jA:
0.0		 6nmpG-3k1jA:
10.52
6nmpN-3k1jA:
22.45
6nmpO-3k1jA:
16.19