SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 9 LEU A 179
ILE A 183
LEU A 163
GLY A 189
LEU A 194
 None
CL  A 436 (-4.3A)
None
SO4  A 435 (-3.5A)
None
 1.04A 1e7aB-3k1tA:
undetectable		 1e7aB-3k1tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 6 PRO A  13
ASN A 233
TRP A 230
TYR A 271
 None
 1.20A 1hpkA-3k1tA:
undetectable		 1hpkA-3k1tA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 8 LEU A  49
GLU A 334
THR A 383
ILE A 345
 None
 1.07A 1qvtA-3k1tA:
undetectable		 1qvtA-3k1tA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 12 LEU A 369
MET A 312
LEU A 253
VAL A 295
ILE A 292
 None
None
GOL  A 439 ( 4.9A)
None
None
 1.36A 1uobA-3k1tA:
undetectable		 1uobA-3k1tA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		3 / 3 TRP A 230
GLU A 270
TYR A 271
 None
 1.19A 2a3aA-3k1tA:
undetectable		 2a3aA-3k1tA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 4 LEU A 121
ILE A 195
ILE A  90
ALA A  86
 None
 0.82A 2i30A-3k1tA:
undetectable		 2i30A-3k1tA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 11 TRP A 202
ASN A 177
PHE A  64
ILE A 195
TYR A  44
 None
None
GOL  A 438 (-4.8A)
None
None
 1.28A 2iyfA-3k1tA:
undetectable		 2iyfA-3k1tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 6 VAL A 128
GLN A 192
ARG A 129
ARG A 162
 None
 1.17A 3bjwF-3k1tA:
undetectable		 3bjwF-3k1tA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 10 ILE A 225
ILE A  28
GLY A 405
VAL A 217
LEU A  17
 None
None
None
GOL  A 446 ( 4.1A)
None
 1.16A 3elzB-3k1tA:
undetectable		 3elzB-3k1tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 8 TYR A 214
LEU A 224
PRO A 223
TRP A  31
 None
 1.21A 3jq7B-3k1tA:
undetectable		 3jq7B-3k1tA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 10 LEU A  98
ILE A 133
LEU A 187
TYR A 110
THR A 118
 None
None
None
None
GOL  A 445 (-2.7A)
 1.13A 3jw3A-3k1tA:
undetectable		 3jw3A-3k1tA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 12 ILE A 292
PHE A 244
LEU A 326
VAL A 257
LEU A 253
 None
GOL  A 439 (-4.4A)
None
None
GOL  A 439 ( 4.9A)
 1.12A 4km2B-3k1tA:
undetectable		 4km2B-3k1tA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 11 TRP A 202
ASN A 177
PHE A  64
ILE A 195
TYR A  44
 None
None
GOL  A 438 (-4.8A)
None
None
 1.27A 4m83A-3k1tA:
undetectable		 4m83A-3k1tA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		5 / 12 LEU A  97
VAL A 128
GLY A 125
ALA A 124
ILE A 120
 None
 1.02A 4xdrA-3k1tA:
undetectable		 4xdrA-3k1tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 7 PHE A  32
ILE A  28
GLY A 405
LEU A  56
 None
 0.95A 4zdzA-3k1tA:
undetectable		 4zdzA-3k1tA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_A_ACTA1229_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 4 VAL A 359
GLU A 334
THR A 332
GLU A 342
 None
None
None
GOL  A 444 (-3.2A)
 1.50A 5g5hA-3k1tA:
0.0		 5g5hA-3k1tA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 5 LEU A 410
LEU A  56
PHE A 221
LEU A  21
 None
 0.93A 5gtrA-3k1tA:
undetectable		 5gtrA-3k1tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 6 LYS A 207
ARG A 205
GLY A 181
ASP A 178
 None
 1.33A 5hp1A-3k1tA:
undetectable		 5hp1A-3k1tA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 5 ARG A 400
LEU A  14
PHE A  54
LEU A   6
 None
 1.24A 5iy5P-3k1tA:
undetectable
5iy5W-3k1tA:
undetectable		 5iy5P-3k1tA:
21.81
5iy5W-3k1tA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		3 / 3 HIS A 115
ASP A 147
HIS A 149
 GOL  A 445 (-3.4A)
None
None
 0.56A 5n1tW-3k1tA:
undetectable		 5n1tW-3k1tA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		3 / 3 CYH A 390
MET A  25
ASN A  24
 None
 1.27A 5qh8A-3k1tA:
undetectable		 5qh8A-3k1tA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 6 ARG A 400
LEU A  14
PHE A  54
LEU A   6
 None
 1.21A 5x19P-3k1tA:
undetectable		 5x19P-3k1tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 5 ARG A 400
LEU A  14
PHE A  54
LEU A   6
 None
 1.19A 5xdxC-3k1tA:
undetectable
5xdxJ-3k1tA:
undetectable		 5xdxC-3k1tA:
22.30
5xdxJ-3k1tA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3k1t GLUTAMATE--CYSTEINE
LIGASE GSHA
(Methylobacillus
flagellatus) 		4 / 5 ARG A 400
LEU A  14
PHE A  54
LEU A   6
 None
 1.22A 5xdxP-3k1tA:
undetectable
5xdxW-3k1tA:
undetectable		 5xdxP-3k1tA:
22.30
5xdxW-3k1tA:
10.36