SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 12 LEU A  10
THR A 120
GLU A 123
ASP A 242
LEU A 231
None
1.32A 1d4fA-3k1zA:
undetectable
1d4fA-3k1zA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
4 / 8 LEU A 101
ALA A  28
LEU A  18
LEU A  19
GOL  A   3 (-4.8A)
None
None
None
0.93A 1dvtA-3k1zA:
undetectable
1dvtB-3k1zA:
undetectable
1dvtA-3k1zA:
17.11
1dvtB-3k1zA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 10 ARG A 125
LEU A 131
VAL A 157
GLY A 143
GLY A 146
None
1.10A 1k6cA-3k1zA:
undetectable
1k6cA-3k1zA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 11 LEU A  45
LEU A  25
ILE A  97
PRO A  96
LEU A  85
None
1.16A 2ft9A-3k1zA:
undetectable
2ft9A-3k1zA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
4 / 5 ASP A 242
LEU A 241
MET A   7
ARG A 127
None
1.25A 2gj5A-3k1zA:
undetectable
2gj5A-3k1zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 11 ALA A 240
LEU A 241
MET A   7
ALA A 188
VAL A 190
None
0.97A 3e22D-3k1zA:
4.0
3e22D-3k1zA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 12 TYR A  63
TYR A  53
ARG A 140
ASP A 138
PHE A 137
None
None
GOL  A   3 (-3.1A)
None
None
1.49A 4b9zA-3k1zA:
undetectable
4b9zA-3k1zA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
3k1z HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo
sapiens)
5 / 12 ASP A 138
PRO A  61
TYR A  53
SER A  71
GLY A  64
None
1.09A 4mmdB-3k1zA:
undetectable
4mmdB-3k1zA:
18.94