SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		6 / 11 PHE A 131
ILE A 139
LEU A 144
MET A 168
VAL A 172
MET A 188
 None
 0.69A 1dtlA-3k21A:
9.5		 1dtlA-3k21A:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		5 / 11 TYR A 149
LEU A  37
ALA A  38
ALA A 127
THR A 141
 None
 1.06A 1jinA-3k21A:
undetectable		 1jinA-3k21A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		5 / 10 VAL A 172
ILE A 180
PHE A  34
ALA A  38
ILE A 124
 None
 1.10A 3me6A-3k21A:
undetectable		 3me6A-3k21A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		4 / 8 VAL A 133
TYR A 125
ILE A 147
ILE A 139
 None
 0.97A 4afgD-3k21A:
undetectable
4afgE-3k21A:
undetectable		 4afgD-3k21A:
20.82
4afgE-3k21A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		4 / 8 ILE A 104
PHE A  89
GLY A  77
GLU A  63
 None
 0.89A 4fgjA-3k21A:
undetectable
4fgjB-3k21A:
undetectable		 4fgjA-3k21A:
22.31
4fgjB-3k21A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		5 / 8 PHE A 131
ILE A 139
LEU A 144
MET A 168
MET A 188
 None
 0.71A 4rjdA-3k21A:
11.3		 4rjdA-3k21A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		5 / 7 PHE A 131
LEU A 144
MET A 168
MET A 188
MET A 189
 None
 0.71A 4rjdB-3k21A:
11.0		 4rjdB-3k21A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3
(Plasmodium
falciparum) 		5 / 10 LEU A 144
MET A 168
VAL A 172
ILE A 180
MET A 189
 None
 0.67A 5v02B-3k21A:
undetectable
5v02R-3k21A:
7.6		 5v02B-3k21A:
22.04
5v02R-3k21A:
31.12