SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 ALA A 209
CYH A  71
GLY A  72
HIS A 164
 None
 0.79A 1sv9A-3k25A:
undetectable		 1sv9A-3k25A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.88A 2gehA-3k25A:
undetectable		 2gehA-3k25A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.86A 2it4A-3k25A:
undetectable		 2it4A-3k25A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A 147
LEU A  34
LEU A  25
PHE A 284
LEU A 161
 None
 1.30A 3adxA-3k25A:
undetectable		 3adxA-3k25A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A  59
LEU A 161
LEU A  34
GLY A  32
TYR A 136
 None
 1.16A 3k2hB-3k25A:
undetectable		 3k2hB-3k25A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 209
GLN A 187
HIS A  91
HIS A 164
ASP A 207
 None
 1.36A 3njzA-3k25A:
undetectable		 3njzA-3k25A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.98A 3nlqA-3k25A:
undetectable
3nlqB-3k25A:
undetectable		 3nlqA-3k25A:
22.72
3nlqB-3k25A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLN A 187
HIS A 164
HIS A  91
ASP A 207
 None
 1.07A 3nvcA-3k25A:
undetectable		 3nvcA-3k25A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 117
HIS A 118
ASP A 120
GLU A 100
 None
 0.90A 3sg9B-3k25A:
0.8		 3sg9B-3k25A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A 240
LEU A 253
ILE A  64
ILE A  66
PHE A 233
 None
 1.31A 3tmzA-3k25A:
undetectable		 3tmzA-3k25A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.95A 4cwxA-3k25A:
undetectable
4cwxB-3k25A:
undetectable		 4cwxA-3k25A:
21.71
4cwxB-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.95A 4cwyA-3k25A:
undetectable
4cwyB-3k25A:
undetectable		 4cwyA-3k25A:
21.71
4cwyB-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.95A 4cwyA-3k25A:
undetectable
4cwyB-3k25A:
undetectable		 4cwyA-3k25A:
21.71
4cwyB-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE A 179
LEU A 240
PHE A 210
THR A 244
 None
 1.01A 5b1aN-3k25A:
undetectable
5b1aW-3k25A:
undetectable		 5b1aN-3k25A:
17.92
5b1aW-3k25A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.79A 5ogjA-3k25A:
undetectable		 5ogjA-3k25A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.81A 5ogjB-3k25A:
undetectable		 5ogjB-3k25A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.81A 5ohhA-3k25A:
undetectable		 5ohhA-3k25A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 6 HIS A 141
VAL A  40
LEU A 227
THR A 288
 None
 0.79A 5ohhB-3k25A:
undetectable		 5ohhB-3k25A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.93A 5uo9A-3k25A:
undetectable
5uo9B-3k25A:
undetectable		 5uo9A-3k25A:
20.67
5uo9B-3k25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.97A 5uo9C-3k25A:
undetectable
5uo9D-3k25A:
undetectable		 5uo9C-3k25A:
20.67
5uo9D-3k25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.98A 5vv9A-3k25A:
undetectable
5vv9B-3k25A:
undetectable		 5vv9A-3k25A:
21.71
5vv9B-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.97A 5vvaA-3k25A:
undetectable
5vvaB-3k25A:
undetectable		 5vvaA-3k25A:
21.71
5vvaB-3k25A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.94A 5vvdA-3k25A:
undetectable
5vvdB-3k25A:
undetectable		 5vvdA-3k25A:
20.67
5vvdB-3k25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.92A 6av6A-3k25A:
undetectable
6av6B-3k25A:
undetectable		 6av6A-3k25A:
17.86
6av6B-3k25A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 256
PHE A 233
GLU A 254
VAL A 241
 None
 0.93A 6cieA-3k25A:
undetectable
6cieB-3k25A:
undetectable		 6cieA-3k25A:
17.86
6cieB-3k25A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 241
TRP A 256
PHE A 233
GLU A 254
 None
 0.97A 6cifC-3k25A:
undetectable
6cifD-3k25A:
undetectable		 6cifC-3k25A:
17.86
6cifD-3k25A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP A  99
VAL A  28
THR A  13
PHE A  53
TYR A 136
 None
 1.37A 6drxA-3k25A:
undetectable		 6drxA-3k25A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3k25 SLR1438 PROTEIN
(Synechocystis
sp.
PCC
6803) 		4 / 5 ILE A 213
SER A 214
ALA A 178
LEU A 253
 None
 1.04A 6dwnA-3k25A:
undetectable		 6dwnA-3k25A:
13.50