SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 144
ALA A 134
LEU A  25
PRO A  24
ILE A 117
 None
 1.00A 1df7A-3k2bA:
undetectable		 1df7A-3k2bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ILE A 144
ALA A 134
LEU A  25
PRO A  24
ILE A 117
 None
 1.08A 1dg5A-3k2bA:
undetectable		 1dg5A-3k2bA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 ASN A 313
TYR A 317
ASN A 152
TYR A 311
 NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
None
None
 1.00A 1dssG-3k2bA:
49.3		 1dssG-3k2bA:
45.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		7 / 7 SER A 148
THR A 150
ASN A 152
CYH A 153
TYR A 311
ASN A 313
TYR A 317
 SO4  A 337 (-3.1A)
SO4  A 337 ( 4.2A)
None
None
None
NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
 0.25A 1dssG-3k2bA:
49.3		 1dssG-3k2bA:
45.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ASN A 313
TYR A 317
ASN A 152
TYR A 311
 NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
None
None
 0.99A 1dssR-3k2bA:
49.2		 1dssR-3k2bA:
45.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		8 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
TYR A 311
ASN A 313
TYR A 317
 SO4  A 337 (-3.1A)
SO4  A 337 ( 4.2A)
None
None
None
None
NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
 0.40A 1dssR-3k2bA:
49.2		 1dssR-3k2bA:
45.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASN A  31
ASP A 101
ILE A 143
PHE A  99
GLY A 106
 NAD  A 335 ( 4.3A)
None
None
NAD  A 335 (-4.4A)
None
 1.48A 1g60B-3k2bA:
undetectable		 1g60B-3k2bA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 154
ALA A 210
VAL A 158
HIS A 176
TYR A 311
 None
SO4  A 337 (-3.3A)
None
None
None
 1.34A 1qabE-3k2bA:
undetectable		 1qabE-3k2bA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 THR A 179
GLU A 314
SER A 238
VAL A 240
 SO4  A 336 (-3.7A)
None
None
None
 1.23A 1tv8B-3k2bA:
undetectable		 1tv8B-3k2bA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 214
GLY A 209
LEU A 242
THR A 174
THR A 151
 None
SO4  A 337 (-4.0A)
None
None
None
 1.02A 2egvA-3k2bA:
3.7		 2egvA-3k2bA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 214
GLY A 209
LEU A 242
THR A 174
THR A 151
 None
SO4  A 337 (-4.0A)
None
None
None
 1.06A 2egvB-3k2bA:
3.5		 2egvB-3k2bA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 177
VAL A 232
SER A 280
VAL A 237
 None
 1.40A 2j9cA-3k2bA:
2.0
2j9cB-3k2bA:
1.9
2j9cC-3k2bA:
1.9		 2j9cA-3k2bA:
16.08
2j9cB-3k2bA:
16.08
2j9cC-3k2bA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ASN A 313
TYR A 317
ASN A 152
TYR A 311
 NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
None
None
 1.02A 3dmtC-3k2bA:
48.9		 3dmtC-3k2bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		8 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
TYR A 311
ASN A 313
TYR A 317
 SO4  A 337 (-3.1A)
SO4  A 337 ( 4.2A)
None
None
None
None
NAD  A 335 (-3.9A)
NAD  A 335 (-3.5A)
 0.33A 3dmtC-3k2bA:
48.9		 3dmtC-3k2bA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ILE A  93
VAL A 100
LYS A 122
GLY A 122
LEU A 324
 None
 1.29A 3em0A-3k2bA:
undetectable		 3em0A-3k2bA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASN A 236
ASP A 312
ASN A 313
 None
None
NAD  A 335 (-3.9A)
 0.76A 4agaA-3k2bA:
undetectable		 4agaA-3k2bA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A  25
PRO A  24
LEU A   1
ILE A  91
 None
 0.96A 4f4dB-3k2bA:
3.6		 4f4dB-3k2bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 267
PHE A 157
VAL A 160
THR A 208
SER A 148
 None
None
None
SO4  A 337 (-3.4A)
SO4  A 337 (-3.1A)
 1.20A 4hvcB-3k2bA:
3.7		 4hvcB-3k2bA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 144
ALA A 134
LEU A  25
PRO A  24
ILE A 117
 None
 1.02A 4m2xC-3k2bA:
2.0		 4m2xC-3k2bA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 144
ALA A 134
LEU A  25
PRO A  24
ILE A 117
 None
 1.04A 4m2xE-3k2bA:
2.0		 4m2xE-3k2bA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 144
ALA A 134
LEU A  25
PRO A  24
ILE A 117
 None
 1.07A 4m2xG-3k2bA:
2.1		 4m2xG-3k2bA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PHE A 157
VAL A 160
THR A 208
SER A 148
GLY A 209
 None
None
SO4  A 337 (-3.4A)
SO4  A 337 (-3.1A)
SO4  A 337 (-4.0A)
 1.42A 4olfA-3k2bA:
2.0		 4olfA-3k2bA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 ALA A 325
VAL A  92
GLY A  95
THR A 119
 None
None
NAD  A 335 (-4.4A)
NAD  A 335 (-4.5A)
 1.09A 4ubeA-3k2bA:
5.4		 4ubeA-3k2bA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 SER A 148
LEU A 154
PRO A 156
VAL A 129
THR A 127
 SO4  A 337 (-3.1A)
None
None
None
None
 1.25A 4uuuB-3k2bA:
undetectable		 4uuuB-3k2bA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 THR A 151
ALA A 147
ASN A 152
 None
 0.58A 5ersA-3k2bA:
2.1		 5ersA-3k2bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 324
TYR A 128
GLY A 122
ILE A 144
VAL A 116
 None
 1.37A 5hjiA-3k2bA:
undetectable		 5hjiA-3k2bA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 VAL A  57
SER A  41
ILE A  30
PHE A   8
 None
 1.06A 5jw1B-3k2bA:
undetectable		 5jw1B-3k2bA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 SER A 207
ALA A 213
TYR A 311
ALA A 210
GLY A 209
 None
None
None
SO4  A 337 (-3.3A)
SO4  A 337 (-4.0A)
 1.15A 5tzoB-3k2bA:
undetectable		 5tzoB-3k2bA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 267
PHE A 157
VAL A 160
THR A 208
SER A 148
 None
None
None
SO4  A 337 (-3.4A)
SO4  A 337 (-3.1A)
 1.22A 5xiqA-3k2bA:
4.5		 5xiqA-3k2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 267
PHE A 157
VAL A 160
THR A 208
SER A 148
 None
None
None
SO4  A 337 (-3.4A)
SO4  A 337 (-3.1A)
 1.14A 5xiqB-3k2bA:
2.2		 5xiqB-3k2bA:
21.13