SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 6 HIS A  32
HIS A  34
HIS A 207
HIS A 236
ASP A 302
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 400 (-2.6A)
 0.79A 1fweC-3k2gA:
13.8		 1fweC-3k2gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 135
GLU A 186
TYR A 134
ALA A 193
GLY A 192
 None
None
DTV  A 402 ( 4.4A)
None
None
 1.39A 1l5rA-3k2gA:
2.4		 1l5rA-3k2gA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 193
GLY A 132
LEU A 221
GLU A 225
ALA A 194
 None
 1.14A 1mjqC-3k2gA:
undetectable
1mjqD-3k2gA:
undetectable		 1mjqC-3k2gA:
14.17
1mjqD-3k2gA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 193
GLY A 132
LEU A 221
GLU A 225
ALA A 194
 None
 1.13A 1mjqI-3k2gA:
undetectable
1mjqJ-3k2gA:
undetectable		 1mjqI-3k2gA:
14.17
1mjqJ-3k2gA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhA-3k2gA:
undetectable		 1nbhA-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhC-3k2gA:
undetectable		 1nbhC-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhD-3k2gA:
undetectable		 1nbhD-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 177
SER A 179
TRP A  42
GLY A 108
SER A 138
 None
None
DTV  A 402 (-3.7A)
None
None
 1.27A 1nbiC-3k2gA:
undetectable		 1nbiC-3k2gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 177
SER A 179
TRP A  42
GLY A 108
SER A 138
 None
None
DTV  A 402 (-3.7A)
None
None
 1.28A 1nbiD-3k2gA:
undetectable		 1nbiD-3k2gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 302
HIS A 236
HIS A  32
 ZN  A 400 (-2.6A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.3A)
 0.64A 1oe1A-3k2gA:
undetectable		 1oe1A-3k2gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 302
HIS A 236
HIS A  32
 ZN  A 400 (-2.6A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.3A)
 0.65A 1oe3A-3k2gA:
undetectable		 1oe3A-3k2gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 PRO A 140
MET A 139
ALA A 136
GLU A 185
 None
 1.37A 1qhyA-3k2gA:
undetectable		 1qhyA-3k2gA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 309
ILE A  87
ALA A  86
THR A 105
VAL A 303
 None
 1.14A 2g78A-3k2gA:
undetectable		 2g78A-3k2gA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 302
HIS A 236
HIS A  32
 ZN  A 400 (-2.6A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.3A)
 0.67A 2xxgA-3k2gA:
undetectable		 2xxgA-3k2gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASP A 302
HIS A 236
HIS A  32
 ZN  A 400 (-2.6A)
ZN  A 401 (-3.5A)
ZN  A 400 (-3.3A)
 0.66A 2xxgC-3k2gA:
undetectable		 2xxgC-3k2gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 132
GLU A 158
GLY A 130
MET A 129
 None
 1.05A 3e9rA-3k2gA:
undetectable		 3e9rA-3k2gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 132
GLU A 158
GLY A 130
MET A 129
 None
 1.08A 3e9rC-3k2gA:
undetectable		 3e9rC-3k2gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.72A 3eeyC-3k2gA:
undetectable		 3eeyC-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.74A 3eeyD-3k2gA:
undetectable		 3eeyD-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.72A 3eeyE-3k2gA:
undetectable		 3eeyE-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 GLN A  69
LEU A  67
GLU A  66
LEU A  54
 None
 0.84A 3h5gA-3k2gA:
undetectable
3h5gC-3k2gA:
undetectable		 3h5gA-3k2gA:
5.77
3h5gC-3k2gA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 ARG A 191
GLY A 192
GLU A 224
GLU A 225
 None
 1.10A 3k9fA-3k2gA:
undetectable
3k9fB-3k2gA:
undetectable
3k9fD-3k2gA:
undetectable		 3k9fA-3k2gA:
23.67
3k9fB-3k2gA:
23.67
3k9fD-3k2gA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.89A 3p50A-3k2gA:
undetectable		 3p50A-3k2gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.89A 3p50B-3k2gA:
undetectable		 3p50B-3k2gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.89A 3p50C-3k2gA:
undetectable		 3p50C-3k2gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.88A 3p50D-3k2gA:
undetectable		 3p50D-3k2gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 7 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.89A 3p50E-3k2gA:
undetectable		 3p50E-3k2gA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RHG_A_BEZA369_0
(PUTATIVE
PHOPHOTRIESTERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		6 / 10 HIS A 207
TRP A 211
HIS A 236
MET A 261
ASP A 302
PHE A 304
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.5A)
None
ZN  A 400 (-2.6A)
DTV  A 402 (-4.2A)
 0.17A 3rhgA-3k2gA:
51.5		 3rhgA-3k2gA:
39.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  74
ALA A  55
LYS A  75
 None
 0.95A 3runA-3k2gA:
undetectable		 3runA-3k2gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 257
PHE A 324
LEU A 299
GLY A 287
LEU A 286
 None
 1.29A 3tbgA-3k2gA:
undetectable		 3tbgA-3k2gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 257
PHE A 324
LEU A 299
GLY A 287
LEU A 286
 None
 1.32A 3tbgC-3k2gA:
undetectable		 3tbgC-3k2gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 176
ALA A 193
GLY A 192
GLU A 225
GLY A 201
 None
 1.19A 4e47B-3k2gA:
undetectable		 4e47B-3k2gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 5 HIS A  32
HIS A 207
HIS A 236
ASP A 302
 ZN  A 400 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 400 (-2.6A)
 0.77A 4h9mA-3k2gA:
4.8		 4h9mA-3k2gA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 176
ALA A 193
GLY A 192
GLU A 225
GLY A 201
 None
 1.21A 4jdsB-3k2gA:
undetectable		 4jdsB-3k2gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 176
ALA A 193
GLY A 192
GLU A 225
GLY A 201
 None
 1.23A 4jlgA-3k2gA:
undetectable		 4jlgA-3k2gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ASP A 167
ARG A 169
SER A   5
LEU A 202
PRO A  20
 None
 1.48A 4kmuH-3k2gA:
0.0		 4kmuH-3k2gA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 257
PHE A 259
LEU A 234
PRO A 209
VAL A 178
 None
 1.50A 4mk4B-3k2gA:
0.8		 4mk4B-3k2gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 221
ALA A 227
ARG A 191
GLY A 192
VAL A 206
 None
 0.85A 4nkvA-3k2gA:
undetectable		 4nkvA-3k2gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.08A 4pahA-3k2gA:
undetectable		 4pahA-3k2gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 6 HIS A  32
HIS A  34
HIS A 207
HIS A 236
ASP A 302
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 400 (-2.6A)
 0.67A 4ubpC-3k2gA:
14.1		 4ubpC-3k2gA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 5 GLU A 175
MET A  31
LEU A 298
HIS A 231
 ZN  A 401 ( 2.6A)
None
None
None
 1.21A 4xi3B-3k2gA:
undetectable		 4xi3B-3k2gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ILE A  21
PRO A  22
ILE A  14
 None
 0.44A 5hw8F-3k2gA:
undetectable		 5hw8F-3k2gA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 10 ILE A 262
ILE A 297
LEU A 288
PRO A 244
LEU A 325
 None
 1.16A 5ienB-3k2gA:
undetectable		 5ienB-3k2gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 5 PRO A 104
HIS A 301
TYR A 268
PHE A 266
 None
 1.48A 5igjA-3k2gA:
undetectable		 5igjA-3k2gA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 177
ARG A 107
ILE A 155
LEU A 190
ALA A 193
 None
 0.95A 5l0zA-3k2gA:
2.8		 5l0zA-3k2gA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.07A 5pahA-3k2gA:
undetectable		 5pahA-3k2gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.09A 6pahA-3k2gA:
undetectable		 6pahA-3k2gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 204
HIS A  32
HIS A 236
GLU A 175
 None
ZN  A 400 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 2.6A)
 1.09A 6pahA-3k2gA:
undetectable		 6pahA-3k2gA:
21.95