SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		5 / 12 PHE A 424
LEU A 398
LEU A 405
ILE A 401
LEU A 357
 None
 1.07A 2bdmA-3k2jA:
undetectable		 2bdmA-3k2jA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 4 ASP A 460
ASP A 459
GLY A 346
THR A 412
 None
None
CL  A   1 (-4.3A)
None
 1.39A 3tl9B-3k2jA:
undetectable		 3tl9B-3k2jA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		5 / 7 TYR A 388
MET A 423
ALA A 427
ASN A 431
ILE A 437
 None
 0.62A 4y03A-3k2jA:
19.2		 4y03A-3k2jA:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 5 TYR A 388
ALA A 427
ASN A 431
ILE A 437
 None
 0.53A 4y03B-3k2jA:
19.3		 4y03B-3k2jA:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 6 PRO A 375
TYR A 388
ASN A 431
ILE A 437
 CL  A   2 ( 4.2A)
None
None
None
 0.85A 5pbeA-3k2jA:
16.1		 5pbeA-3k2jA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2j PROTEIN POLYBROMO-1
(Homo
sapiens) 		4 / 8 PRO A 375
TYR A 430
ASN A 431
ILE A 437
 CL  A   2 ( 4.2A)
None
None
None
 0.50A 5y1yA-3k2jA:
13.8		 5y1yA-3k2jA:
26.32