SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 GLY A 223
TRP A  40
GLY A  12
VAL A  75
 None
 0.86A 1dbbH-3k2kA:
undetectable
1dbbL-3k2kA:
undetectable		 1dbbH-3k2kA:
18.00
1dbbL-3k2kA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 7 TYR A  90
ASN A  59
TRP A  69
GLY A  31
 None
 1.13A 1mxgA-3k2kA:
3.3		 1mxgA-3k2kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 LEU A   3
TYR A  78
CYH A  53
TYR A 108
 None
 1.46A 1uw6P-3k2kA:
undetectable
1uw6T-3k2kA:
undetectable		 1uw6P-3k2kA:
19.30
1uw6T-3k2kA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 7 TYR A  65
GLU A 174
HIS A 268
GLY A 269
 None
 1.15A 2ha4B-3k2kA:
3.5		 2ha4B-3k2kA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 271
HIS A 171
GLU A 174
 None
CL  A 387 (-4.6A)
None
 0.80A 2x45B-3k2kA:
undetectable		 2x45B-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 271
HIS A 268
GLU A 344
 None
 0.78A 2x45B-3k2kA:
undetectable		 2x45B-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 344
HIS A 171
GLU A 174
 None
CL  A 387 (-4.6A)
None
 0.67A 2x45B-3k2kA:
undetectable		 2x45B-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 271
HIS A 171
GLU A 174
 None
CL  A 387 (-4.6A)
None
 0.81A 2x45C-3k2kA:
undetectable		 2x45C-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 271
HIS A 268
GLU A 344
 None
 0.81A 2x45C-3k2kA:
undetectable		 2x45C-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 GLU A 344
HIS A 171
GLU A 174
 None
CL  A 387 (-4.6A)
None
 0.70A 2x45C-3k2kA:
undetectable		 2x45C-3k2kA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 LYS A 186
ILE A 358
PHE A  84
 None
 0.86A 3j7zS-3k2kA:
undetectable
3j7za-3k2kA:
undetectable		 3j7zS-3k2kA:
13.40
3j7za-3k2kA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 4 ASP A 272
ASP A 270
GLY A 314
THR A 342
 None
 1.39A 3tl9B-3k2kA:
undetectable		 3tl9B-3k2kA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.76A 3u5kA-3k2kA:
undetectable		 3u5kA-3k2kA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 7 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.83A 3u5kB-3k2kA:
undetectable		 3u5kB-3k2kA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.76A 3u5kC-3k2kA:
undetectable		 3u5kC-3k2kA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.93A 3u5kD-3k2kA:
undetectable		 3u5kD-3k2kA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 PHE A  84
VAL A  86
MET A  55
ILE A  97
 None
 1.08A 4a97G-3k2kA:
undetectable		 4a97G-3k2kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.84A 4a9jA-3k2kA:
undetectable		 4a9jA-3k2kA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.85A 4a9jB-3k2kA:
undetectable		 4a9jB-3k2kA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.89A 4a9jC-3k2kA:
undetectable		 4a9jC-3k2kA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 10 ALA A 132
PRO A 213
ILE A 181
LEU A 184
ILE A 211
 None
 1.20A 4dtaA-3k2kA:
undetectable		 4dtaA-3k2kA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 PHE A  43
ALA A  74
THR A  88
LEU A  27
 None
 0.89A 4ejgB-3k2kA:
undetectable		 4ejgB-3k2kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 8 ARG A 144
ASN A 228
GLY A 231
ALA A 232
THR A 140
 None
 1.38A 4eyrB-3k2kA:
undetectable		 4eyrB-3k2kA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 12 LEU A 343
ALA A 305
ILE A 166
GLY A 369
GLY A 183
 None
 1.29A 4hfpB-3k2kA:
undetectable		 4hfpB-3k2kA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 6 ASP A 266
GLU A 174
ASN A 233
ARG A 236
 None
None
CL  A 387 ( 4.9A)
CL  A 387 (-2.9A)
 1.33A 4ntxA-3k2kA:
undetectable
4ntxC-3k2kA:
undetectable		 4ntxA-3k2kA:
23.08
4ntxC-3k2kA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 4 GLU A 271
GLY A 269
HIS A 171
ARG A 226
 None
None
CL  A 387 (-4.6A)
CL  A 387 (-3.9A)
 1.46A 4r82A-3k2kA:
0.0
4r82B-3k2kA:
0.0		 4r82A-3k2kA:
18.95
4r82B-3k2kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 7 GLN A 170
TYR A 320
ASN A 233
HIS A 268
 None
CL  A 387 ( 4.9A)
CL  A 387 ( 4.9A)
None
 1.13A 4ws0A-3k2kA:
2.8		 4ws0A-3k2kA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 12 LEU A 203
VAL A 164
VAL A 380
LEU A 188
TYR A 204
 None
 1.45A 5cymA-3k2kA:
undetectable		 5cymA-3k2kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 12 LEU A 203
VAL A 164
VAL A 380
LEU A 188
TYR A 204
 None
 1.45A 5cyqA-3k2kA:
undetectable		 5cyqA-3k2kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 12 ILE A 166
PHE A 209
ALA A 375
LEU A 203
VAL A 164
 None
 0.92A 5km9B-3k2kA:
undetectable		 5km9B-3k2kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		5 / 12 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
None
CL  A 388 ( 4.9A)
None
None
 0.93A 5l6eA-3k2kA:
undetectable		 5l6eA-3k2kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 6 PHE A  57
ILE A  14
ASP A  32
GLY A  31
 None
 0.98A 5x5qE-3k2kA:
undetectable		 5x5qE-3k2kA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 5 HIS A 119
ASP A 218
GLY A 219
ASN A 214
 GOL  A 389 (-3.9A)
None
None
None
 1.31A 5x7pB-3k2kA:
2.9		 5x7pB-3k2kA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 THR A 342
GLU A 344
HIS A 171
 None
None
CL  A 387 (-4.6A)
 0.88A 5xioA-3k2kA:
undetectable		 5xioA-3k2kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		3 / 3 THR A 342
GLU A 344
HIS A 171
 None
None
CL  A 387 (-4.6A)
 0.90A 5xiqB-3k2kA:
undetectable		 5xiqB-3k2kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.72A 5y1yA-3k2kA:
undetectable		 5y1yA-3k2kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3k2k PUTATIVE
CARBOXYPEPTIDASE
(Burkholderia
mallei) 		4 / 7 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.11A 6j20A-3k2kA:
undetectable		 6j20A-3k2kA:
20.59