SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3k2m PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		5 / 12 LEU A 160
VAL A 218
LEU A 184
LEU A 232
HIS A 148
 None
 1.32A 1mx1E-3k2mA:
undetectable		 1mx1E-3k2mA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3k2m PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens) 		5 / 10 VAL A 151
LEU A 169
LEU A 160
SER A 183
ALA A 155
 None
 1.37A 1pbcA-3k2mA:
undetectable		 1pbcA-3k2mA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3k2m MONOBODY HA4
(Homo
sapiens) 		5 / 11 GLN C  51
VAL C  50
PRO C  49
ILE C  96
PRO C  93
 None
 1.16A 3ganA-3k2mC:
undetectable		 3ganA-3k2mC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3k2m MONOBODY HA4
(Homo
sapiens) 		4 / 5 SER C  60
PRO C  56
TYR C  57
VAL C  55
 None
 1.26A 3sufC-3k2mC:
undetectable		 3sufC-3k2mC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3k2m MONOBODY HA4
(Homo
sapiens) 		5 / 12 ILE C  75
VAL C  77
TYR C  37
TYR C  41
ILE C  64
 None
 1.12A 3vrjA-3k2mC:
4.7
3vrjC-3k2mC:
undetectable		 3vrjA-3k2mC:
18.15
3vrjC-3k2mC:
10.94