SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 12 ILE A 157
GLY A 130
ALA A 158
ALA A  50
VAL A  39
 None
 1.02A 2yvlA-3k2nA:
undetectable		 2yvlA-3k2nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 12 VAL A  52
GLY A 130
ALA A 160
LEU A 165
ILE A 129
 None
 1.03A 3ku1H-3k2nA:
undetectable		 3ku1H-3k2nA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 9 ILE A  40
ILE A  41
VAL A 161
ILE A  43
ILE A 129
 None
 0.95A 3p4wB-3k2nA:
undetectable		 3p4wB-3k2nA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 10 ILE A  40
ILE A  41
VAL A 161
ILE A  43
ILE A 129
 None
 0.94A 3p4wD-3k2nA:
3.1		 3p4wD-3k2nA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 10 ILE A  40
ILE A  41
VAL A 161
ILE A  43
ILE A 129
 None
 0.94A 3p4wE-3k2nA:
3.1		 3p4wE-3k2nA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		4 / 7 PHE A  59
VAL A 135
ILE A 117
GLU A  60
 None
 1.12A 4a97E-3k2nA:
3.4		 4a97E-3k2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		4 / 7 PHE A  59
VAL A 135
ILE A 117
GLU A  60
 None
 1.10A 4a97H-3k2nA:
undetectable		 4a97H-3k2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		4 / 8 PHE A  59
VAL A 135
ILE A 117
GLU A  60
 None
 1.08A 4a97I-3k2nA:
3.4		 4a97I-3k2nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		4 / 7 GLY A 130
THR A  42
ILE A  41
THR A  75
 None
 0.93A 4acaC-3k2nA:
undetectable		 4acaC-3k2nA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		6 / 12 GLY A 130
ILE A 129
PHE A  53
LEU A 119
SER A 133
ILE A 157
 None
 1.49A 4azvA-3k2nA:
undetectable		 4azvA-3k2nA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		4 / 8 SER A 120
LEU A 132
PHE A 134
TRP A 142
 None
 1.22A 4j7uD-3k2nA:
undetectable		 4j7uD-3k2nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 12 ALA A  50
ILE A  91
HIS A 110
LEU A  61
GLY A 113
 None
 1.17A 4l9qA-3k2nA:
undetectable		 4l9qA-3k2nA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 12 ALA A  50
ILE A  91
HIS A 110
LEU A  61
GLY A 113
 None
 1.20A 4l9qB-3k2nA:
undetectable		 4l9qB-3k2nA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 12 ALA A 158
LEU A 122
GLY A 152
SER A 151
PRO A 121
 None
 1.44A 5jglB-3k2nA:
undetectable		 5jglB-3k2nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR
(Chlorobaculum
tepidum) 		5 / 10 LEU A 150
ALA A 158
GLY A 130
ILE A  41
VAL A  86
 None
 1.01A 5kr1A-3k2nA:
undetectable		 5kr1A-3k2nA:
17.16