SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 VAL A 159
ALA A 302
GLU A 169
LEU A 187
ILE A 163
 None
 1.14A 1d1gB-3k2qA:
undetectable		 1d1gB-3k2qA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 ASN A 145
GLY A 195
ALA A 200
LEU A 383
 None
 0.80A 1e7bB-3k2qA:
undetectable		 1e7bB-3k2qA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.88A 1t86A-3k2qA:
undetectable		 1t86A-3k2qA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.42A 1y0xX-3k2qA:
undetectable		 1y0xX-3k2qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 TYR A  93
TYR A 110
PHE A 108
GLY A  45
 None
 1.06A 2ha4A-3k2qA:
undetectable		 2ha4A-3k2qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 6 LEU A 286
VAL A 282
VAL A 214
VAL A 243
 None
 0.97A 2z97A-3k2qA:
undetectable		 2z97A-3k2qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSF_A_ACTA803_0
(PANTOTHENATE KINASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 ARG A 192
PRO A 218
GLY A 191
HIS A 193
 None
 1.30A 2zsfA-3k2qA:
0.2		 2zsfA-3k2qA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		6 / 12 ALA A 306
ASP A 310
ILE A 387
GLY A 389
THR A 165
ILE A 305
 None
 1.50A 3d1yA-3k2qA:
undetectable		 3d1yA-3k2qA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 GLU A 169
LEU A 172
ASP A 173
 None
 0.22A 3ko0A-3k2qA:
undetectable		 3ko0A-3k2qA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 GLU A 169
LEU A 172
ASP A 173
 None
 0.23A 3ko0T-3k2qA:
0.6		 3ko0T-3k2qA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A  74
ALA A  75
ALA A 403
LEU A 405
ASN A 407
 None
 1.18A 3p5nA-3k2qA:
undetectable		 3p5nA-3k2qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 PHE A 100
GLY A  42
VAL A 123
TYR A 110
PHE A 108
 None
 1.48A 3r6wA-3k2qA:
4.3
3r6wB-3k2qA:
3.5		 3r6wA-3k2qA:
20.05
3r6wB-3k2qA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 4 ASP A 144
ASP A 146
GLY A 113
THR A 150
 None
 1.27A 3tl9B-3k2qA:
undetectable		 3tl9B-3k2qA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 PHE A 392
LYS A 161
SER A 158
 None
 1.33A 3tyeB-3k2qA:
undetectable		 3tyeB-3k2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 THR A  71
GLN A  27
ASN A  19
GLY A  24
ALA A 308
 None
 1.27A 3v3oA-3k2qA:
undetectable		 3v3oA-3k2qA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 9 ILE A 368
GLY A 374
PHE A 217
GLY A 195
ARG A 255
 None
 1.33A 4acaB-3k2qA:
3.4
4acaC-3k2qA:
3.4		 4acaB-3k2qA:
21.53
4acaC-3k2qA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 ARG A 230
GLU A 208
ASN A 371
 None
 0.69A 4imaD-3k2qA:
3.1		 4imaD-3k2qA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		3 / 3 ARG A 230
GLU A 208
ASN A 371
 None
 0.69A 4ip7D-3k2qA:
undetectable		 4ip7D-3k2qA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 ILE A 348
ASN A 145
TYR A 382
TRP A 346
LEU A 386
 None
 1.32A 4jq4B-3k2qA:
undetectable		 4jq4B-3k2qA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 ALA A  22
THR A  71
GLY A  73
GLY A  74
ALA A  75
 None
 0.92A 4qvpK-3k2qA:
undetectable
4qvpL-3k2qA:
undetectable		 4qvpK-3k2qA:
21.40
4qvpL-3k2qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 10 ALA A  22
THR A  71
GLY A  73
GLY A  74
ALA A  75
 None
 0.92A 4qvpY-3k2qA:
undetectable
4qvpZ-3k2qA:
undetectable		 4qvpY-3k2qA:
21.40
4qvpZ-3k2qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ARG A 303
SER A 158
GLY A 155
ALA A  75
GLY A  73
 None
 1.29A 4r29B-3k2qA:
undetectable		 4r29B-3k2qA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 SER A 116
TYR A 110
GLY A 112
GLY A  13
 None
 0.90A 5albL-3k2qA:
undetectable		 5albL-3k2qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLU A  53
GLY A  45
ASN A  44
ALA A  75
ASN A 407
 None
 1.39A 5kc4A-3k2qA:
undetectable		 5kc4A-3k2qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 9 LEU A  96
GLY A  45
ALA A   9
GLY A 112
VAL A 123
 None
 0.96A 5kr0B-3k2qA:
undetectable		 5kr0B-3k2qA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 215
VAL A 244
THR A 167
ILE A 163
ALA A 160
 None
 1.00A 5lg3E-3k2qA:
undetectable		 5lg3E-3k2qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 7 TYR A   8
VAL A  39
ILE A  36
VAL A  25
ALA A  29
 None
 1.12A 5ospA-3k2qA:
undetectable		 5ospA-3k2qA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 138
LEU A  54
GLY A  45
SER A  11
ILE A  46
 None
 1.16A 5vooA-3k2qA:
undetectable		 5vooA-3k2qA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 GLY A 138
LEU A  54
GLY A  45
SER A  11
ILE A  46
 None
 1.16A 5vooC-3k2qA:
2.6		 5vooC-3k2qA:
21.33