SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		4 / 6 LEU A  12
TYR A  54
ILE A  67
ILE A  71
 None
 0.91A 2q8hA-3k2zA:
undetectable		 2q8hA-3k2zA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		6 / 12 ILE A  15
VAL A  11
ILE A  37
GLY A  41
ALA A  42
LEU A  65
 None
 1.14A 4o1zA-3k2zA:
undetectable		 4o1zA-3k2zA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 9 VAL A 131
LEU A 132
GLY A 188
ALA A 146
LEU A 155
 None
 1.12A 4rs0A-3k2zA:
undetectable		 4rs0A-3k2zA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 10 GLY A 192
VAL A 131
VAL A 190
MET A 120
LEU A 155
 None
 1.33A 4yb6C-3k2zA:
undetectable
4yb6F-3k2zA:
undetectable		 4yb6C-3k2zA:
22.48
4yb6F-3k2zA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 10 MET A 120
LEU A 155
GLY A 192
VAL A 131
VAL A 190
 None
 1.31A 4yb6A-3k2zA:
undetectable
4yb6D-3k2zA:
undetectable		 4yb6A-3k2zA:
22.48
4yb6D-3k2zA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 10 MET A 120
LEU A 155
GLY A 192
VAL A 131
VAL A 190
 None
 1.31A 4yb6D-3k2zA:
undetectable
4yb6E-3k2zA:
undetectable		 4yb6D-3k2zA:
22.48
4yb6E-3k2zA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 11 VAL A 131
VAL A 190
PHE A 111
ILE A  81
LEU A 155
 None
 1.10A 5e4dB-3k2zA:
undetectable		 5e4dB-3k2zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 11 VAL A 190
VAL A 131
VAL A 193
ILE A 121
LEU A 155
 None
 1.09A 5e4dB-3k2zA:
undetectable		 5e4dB-3k2zA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		5 / 12 GLY A 142
PHE A 158
HIS A 124
VAL A 131
LEU A 155
 None
 1.15A 5ergB-3k2zA:
undetectable		 5ergB-3k2zA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3k2z LEXA REPRESSOR
(Thermotoga
maritima) 		4 / 5 PRO A  39
ALA A  42
ALA A  32
ILE A  37
 None
 0.78A 5jncD-3k2zA:
undetectable		 5jncD-3k2zA:
21.71