SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 5 LEU A 429
LEU A 433
LEU A 393
GLY A 372
 None
 0.87A 1a4lC-3k3nA:
undetectable		 1a4lC-3k3nA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 8 GLU A 436
ARG A 383
ARG A 380
LEU A 376
 None
 1.07A 1cmaA-3k3nA:
undetectable
1cmaB-3k3nA:
undetectable		 1cmaA-3k3nA:
14.63
1cmaB-3k3nA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 SER A 337
GLY A 372
GLY A 397
VAL A 424
THR A 423
 None
 1.06A 2nyuB-3k3nA:
undetectable		 2nyuB-3k3nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 6 ASP A 249
HIS A 319
TYR A 257
ASN A 189
 FE2  A   1 (-2.5A)
FE2  A   1 (-3.3A)
None
None
 1.10A 2zs9A-3k3nA:
undetectable		 2zs9A-3k3nA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 8 LEU A 276
ILE A 318
PHE A 246
GLY A 294
 None
 0.88A 3b9lA-3k3nA:
2.2		 3b9lA-3k3nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 4 SER A 139
PRO A 140
PHE A 142
PRO A 138
 None
 1.48A 3bjwA-3k3nA:
0.0		 3bjwA-3k3nA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gB-3k3nA:
undetectable		 3j6gB-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gD-3k3nA:
undetectable		 3j6gD-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gF-3k3nA:
undetectable		 3j6gF-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gH-3k3nA:
undetectable		 3j6gH-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gJ-3k3nA:
undetectable		 3j6gJ-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gL-3k3nA:
undetectable		 3j6gL-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gN-3k3nA:
undetectable		 3j6gN-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gP-3k3nA:
undetectable		 3j6gP-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 VAL A 147
ASP A 146
LEU A 236
THR A 310
LEU A 137
 None
 1.06A 3j6gR-3k3nA:
undetectable		 3j6gR-3k3nA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 7 TYR A 370
GLU A 222
TRP A 220
ASN A 363
 None
 1.29A 3k8mA-3k3nA:
undetectable		 3k8mA-3k3nA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 10 LEU A 236
HIS A 247
ASP A 249
ILE A 313
HIS A 319
 None
FE2  A   1 (-3.4A)
FE2  A   1 (-2.5A)
None
FE2  A   1 (-3.3A)
 0.72A 3kcxA-3k3nA:
17.5		 3kcxA-3k3nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		6 / 10 THR A 244
HIS A 247
ASP A 249
LYS A 264
ILE A 313
HIS A 319
 None
FE2  A   1 (-3.4A)
FE2  A   1 (-2.5A)
None
None
FE2  A   1 (-3.3A)
 1.00A 3kcxA-3k3nA:
17.5		 3kcxA-3k3nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 7 GLY A 396
GLY A 397
ALA A 399
ILE A 437
 None
 0.70A 4yjiA-3k3nA:
undetectable		 4yjiA-3k3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		4 / 4 CYH A 368
LEU A 344
LEU A 400
ALA A 399
 None
 1.02A 5hpuA-3k3nA:
undetectable
5hpuB-3k3nA:
undetectable		 5hpuA-3k3nA:
5.29
5hpuB-3k3nA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
 0.88A 6ectA-3k3nA:
undetectable		 6ectA-3k3nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3k3n PHD FINGER PROTEIN 8
(Homo
sapiens) 		5 / 12 GLY A 108
GLY A 132
ILE A 209
VAL A 127
ILE A 125
 None
 0.85A 6ecxA-3k3nA:
undetectable		 6ecxA-3k3nA:
22.08