SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 8 SER A  26
PHE A 309
LEU A 333
LEU A 324
 None
 1.04A 2bfpA-3k3pA:
undetectable		 2bfpA-3k3pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 5 LEU A 280
VAL A  89
LEU A   9
MET A 126
 None
 0.91A 2oiqA-3k3pA:
undetectable		 2oiqA-3k3pA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 6 ILE A 103
PHE A  49
GLY A  12
GLY A  11
 None
 0.82A 2qx6A-3k3pA:
3.3
2qx6B-3k3pA:
3.3		 2qx6A-3k3pA:
19.95
2qx6B-3k3pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 6 SER A  26
PHE A 309
TYR A 326
PRO A 307
 None
 1.41A 3jqaA-3k3pA:
2.5		 3jqaA-3k3pA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 6 SER A  26
PHE A 309
TYR A 326
PRO A 307
 None
 1.40A 3jqaC-3k3pA:
2.1		 3jqaC-3k3pA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 8 PRO A 316
MET A 314
SER A 313
ASP A 289
 None
 0.82A 3lsfH-3k3pA:
undetectable		 3lsfH-3k3pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 9 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.12A 3tkdA-3k3pA:
undetectable		 3tkdA-3k3pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 11 LEU A 107
ILE A 103
SER A 286
LEU A   9
LEU A   6
 None
 1.15A 4dm8A-3k3pA:
undetectable		 4dm8A-3k3pA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 6 ARG A  29
ILE A  31
VAL A  38
LEU A   8
 None
 0.87A 4em2A-3k3pA:
undetectable		 4em2A-3k3pA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 5 LEU A  93
PRO A  91
LEU A   9
ILE A  43
 None
 0.96A 4klrA-3k3pA:
4.2		 4klrA-3k3pA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		4 / 8 ASN A  35
GLU A   4
GLU A 331
TYR A 114
 None
 1.06A 4mj8A-3k3pA:
undetectable
4mj8C-3k3pA:
undetectable		 4mj8A-3k3pA:
18.44
4mj8C-3k3pA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		3 / 3 ASP A 127
VAL A 134
LEU A 280
 None
 0.58A 5e5jB-3k3pA:
undetectable		 5e5jB-3k3pA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 10 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.04A 6dlzA-3k3pA:
3.0
6dlzD-3k3pA:
2.9		 6dlzA-3k3pA:
14.60
6dlzD-3k3pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 10 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.04A 6dlzB-3k3pA:
3.0
6dlzC-3k3pA:
3.1		 6dlzB-3k3pA:
14.60
6dlzC-3k3pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 9 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.06A 6dm0A-3k3pA:
0.0
6dm0D-3k3pA:
3.0		 6dm0A-3k3pA:
14.60
6dm0D-3k3pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 9 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.06A 6dm0B-3k3pA:
3.0
6dm0C-3k3pA:
0.0		 6dm0B-3k3pA:
14.60
6dm0C-3k3pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 10 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.05A 6dm1A-3k3pA:
3.1
6dm1D-3k3pA:
3.0		 6dm1A-3k3pA:
14.60
6dm1D-3k3pA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3k3p D-ALANINE--D-ALANINE
LIGASE
(Streptococcus
mutans) 		5 / 10 PRO A 316
MET A 314
SER A 313
LEU A 285
ASP A 289
 None
 1.05A 6dm1B-3k3pA:
3.0
6dm1C-3k3pA:
3.0		 6dm1B-3k3pA:
14.60
6dm1C-3k3pA:
14.60