SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 259
GLY A 260
LEU A 265
GLY A 218
VAL A 184
 None
 1.19A 1fduC-3k40A:
undetectable		 1fduC-3k40A:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 9 PHE A  80
THR A  82
HIS A 192
THR A 245
HIS A 301
 LLP  A 302 ( 4.7A)
None
LLP  A 302 ( 3.6A)
LLP  A 302 ( 4.5A)
LLP  A 302 ( 4.3A)
 0.60A 1js3A-3k40A:
55.6
1js3B-3k40A:
55.6		 1js3A-3k40A:
58.64
1js3B-3k40A:
58.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 9 PHE A  80
THR A  82
HIS A 192
THR A 245
HIS A 301
 LLP  A 302 ( 4.7A)
None
LLP  A 302 ( 3.6A)
LLP  A 302 ( 4.5A)
LLP  A 302 ( 4.3A)
 0.61A 1js3A-3k40A:
55.6
1js3B-3k40A:
55.6		 1js3A-3k40A:
58.64
1js3B-3k40A:
58.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 ASP A 392
PHE A 408
VAL A 464
 None
 0.77A 1kijB-3k40A:
undetectable		 1kijB-3k40A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 11 HIS A 431
SER A 460
VAL A 433
CYH A 448
ILE A 447
 None
 1.22A 2uxpB-3k40A:
undetectable		 2uxpB-3k40A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 TRP A 121
VAL A 116
TRP A 360
 None
 1.10A 2xdcC-3k40A:
undetectable
2xdcD-3k40A:
undetectable		 2xdcC-3k40A:
7.87
2xdcD-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 TRP A 121
VAL A 116
TRP A 360
 None
 1.13A 2xdcE-3k40A:
undetectable
2xdcF-3k40A:
undetectable		 2xdcE-3k40A:
7.87
2xdcF-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 TRP A 121
VAL A 116
TRP A 360
 None
 1.06A 2y5mE-3k40A:
undetectable
2y5mF-3k40A:
undetectable		 2y5mE-3k40A:
7.87
2y5mF-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 TRP A 121
VAL A 116
TRP A 360
 None
 1.07A 2y6nC-3k40A:
undetectable
2y6nD-3k40A:
undetectable		 2y6nC-3k40A:
7.87
2y6nD-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 TRP A 121
VAL A 116
TRP A 360
 None
 1.08A 2y6nE-3k40A:
undetectable
2y6nF-3k40A:
undetectable		 2y6nE-3k40A:
7.87
2y6nF-3k40A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 6 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.96A 3abkP-3k40A:
undetectable
3abkW-3k40A:
undetectable		 3abkP-3k40A:
19.79
3abkW-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 6 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.99A 3wg7P-3k40A:
undetectable
3wg7W-3k40A:
undetectable		 3wg7P-3k40A:
19.79
3wg7W-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		3 / 3 GLY A 275
SER A 276
TRP A 303
 None
 0.95A 4e7cD-3k40A:
undetectable		 4e7cD-3k40A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 239
ALA A 238
GLY A 185
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.14A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 239
ALA A 238
SER A 208
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.30A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 ALA A 110
ILE A  98
LEU A 357
PHE A 354
 None
 0.66A 4uymB-3k40A:
undetectable		 4uymB-3k40A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.94A 5b1aC-3k40A:
undetectable
5b1aJ-3k40A:
undetectable		 5b1aC-3k40A:
19.79
5b1aJ-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.93A 5b1aP-3k40A:
undetectable
5b1aW-3k40A:
undetectable		 5b1aP-3k40A:
19.79
5b1aW-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 1.00A 5b3sC-3k40A:
undetectable
5b3sJ-3k40A:
undetectable		 5b3sC-3k40A:
19.79
5b3sJ-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 LEU A 221
GLY A 218
SER A 292
TYR A 252
TYR A 186
 None
 1.38A 5czyA-3k40A:
undetectable		 5czyA-3k40A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 ILE A 144
GLU A 113
ALA A  91
SER A 108
ILE A 106
 None
 1.10A 5igvA-3k40A:
undetectable		 5igvA-3k40A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 ILE A 144
GLU A 113
ALA A  91
SER A 108
ILE A 106
 None
 1.07A 5igyA-3k40A:
undetectable		 5igyA-3k40A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.96A 5iy5C-3k40A:
undetectable
5iy5J-3k40A:
undetectable		 5iy5C-3k40A:
19.58
5iy5J-3k40A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 8 ARG A 355
ALA A  99
THR A 112
GLY A 102
 None
 1.00A 5v0vA-3k40A:
undetectable		 5v0vA-3k40A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 10 ILE A 430
ILE A 424
LEU A 421
HIS A 378
ILE A 447
 None
 1.41A 5vkqA-3k40A:
0.0
5vkqD-3k40A:
undetectable		 5vkqA-3k40A:
13.98
5vkqD-3k40A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 10 HIS A 378
ILE A 447
ILE A 430
ILE A 424
LEU A 421
 None
 1.41A 5vkqA-3k40A:
0.0
5vkqB-3k40A:
undetectable		 5vkqA-3k40A:
13.98
5vkqB-3k40A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 5 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.97A 5x19C-3k40A:
undetectable
5x19J-3k40A:
undetectable		 5x19C-3k40A:
19.79
5x19J-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 VAL A 240
VAL A 209
GLY A 218
TYR A 252
 None
 0.89A 5x80C-3k40A:
1.5
5x80D-3k40A:
undetectable		 5x80C-3k40A:
15.32
5x80D-3k40A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 ALA A 293
GLY A 257
GLY A 260
LYS A 288
LEU A 128
 None
 1.13A 5ybbA-3k40A:
undetectable		 5ybbA-3k40A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 5 HIS A 301
ALA A 148
SER A 311
GLY A 146
 LLP  A 302 ( 4.3A)
LLP  A 302 ( 3.3A)
None
None
 1.10A 5yodB-3k40A:
undetectable		 5yodB-3k40A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 5 HIS A 301
ALA A 148
SER A 311
GLY A 146
 LLP  A 302 ( 4.3A)
LLP  A 302 ( 3.3A)
None
None
 1.11A 5yodD-3k40A:
undetectable		 5yodD-3k40A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 7 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.95A 5z84C-3k40A:
undetectable
5z84J-3k40A:
undetectable		 5z84C-3k40A:
19.79
5z84J-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 406
GLU A 455
VAL A  29
PHE A 408
PHE A 385
 None
 1.16A 6becA-3k40A:
undetectable
6becB-3k40A:
undetectable
6becC-3k40A:
undetectable		 6becA-3k40A:
21.01
6becB-3k40A:
21.01
6becC-3k40A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 LEU A 350
GLY A 351
GLN A 145
LEU A 153
ARG A 352
 None
 1.09A 6bxmA-3k40A:
2.5		 6bxmA-3k40A:
22.84