SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 802
LEU A 841
ALA A 805
LEU A 798
 None
 1.47A 1f86B-3k49A:
undetectable		 1f86B-3k49A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 SER A 714
LEU A 680
ILE A 687
ILE A 753
LEU A 719
 None
 1.19A 1kyvA-3k49A:
undetectable
1kyvE-3k49A:
undetectable		 1kyvA-3k49A:
19.13
1kyvE-3k49A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 753
LEU A 719
SER A 714
LEU A 680
ILE A 687
 None
 1.20A 1kyvB-3k49A:
undetectable
1kyvC-3k49A:
undetectable		 1kyvB-3k49A:
19.13
1kyvC-3k49A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 753
LEU A 719
SER A 714
LEU A 680
ILE A 687
 None
 1.22A 1kyvC-3k49A:
undetectable
1kyvD-3k49A:
undetectable		 1kyvC-3k49A:
19.13
1kyvD-3k49A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 753
LEU A 719
SER A 714
LEU A 680
ILE A 687
 None
 1.19A 1kyvD-3k49A:
undetectable
1kyvE-3k49A:
undetectable		 1kyvD-3k49A:
19.13
1kyvE-3k49A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 665
TYR A 695
SER A 619
CYH A 625
 A  B   7 ( 3.0A)
A  B   8 ( 4.9A)
None
A  B   8 ( 3.6A)
 1.23A 2xz5C-3k49A:
undetectable
2xz5D-3k49A:
undetectable		 2xz5C-3k49A:
18.77
2xz5D-3k49A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 657
GLN A 621
TYR A 623
GLN A 629
 None
None
U  B   9 ( 4.5A)
A  B   8 ( 3.1A)
 1.14A 3oyaA-3k49A:
undetectable		 3oyaA-3k49A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 722
VAL A 739
ILE A 757
 None
 0.61A 4emaA-3k49A:
undetectable		 4emaA-3k49A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 539
LEU A 544
ASP A 549
GLY A 552
PHE A 555
 None
 1.09A 4foxA-3k49A:
undetectable		 4foxA-3k49A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 539
LEU A 544
ASP A 549
GLY A 552
PHE A 555
 None
 1.10A 4foxB-3k49A:
undetectable		 4foxB-3k49A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 539
LEU A 544
ASP A 549
GLY A 552
PHE A 555
 None
 1.09A 4foxG-3k49A:
undetectable		 4foxG-3k49A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 780
VAL A 761
GLN A 737
GLU A 779
 None
None
U  B   5 ( 2.7A)
G  B   4 ( 3.2A)
 1.12A 5dqyA-3k49A:
undetectable		 5dqyA-3k49A:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 771
LYS A 772
PHE A 773
 None
G  B   4 ( 3.0A)
U  B   5 ( 4.4A)
 0.50A 5klaA-3k49A:
36.9		 5klaA-3k49A:
46.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 592
PHE A 596
ALA A 579
PHE A 611
VAL A 608
 None
 1.29A 5m0oA-3k49A:
undetectable		 5m0oA-3k49A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 802
LEU A 841
ALA A 805
LEU A 798
 None
 1.46A 6gnrA-3k49A:
undetectable		 6gnrA-3k49A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 802
LEU A 841
ALA A 805
LEU A 798
 None
 1.47A 6gnrB-3k49A:
undetectable		 6gnrB-3k49A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3k49 MRNA-BINDING PROTEIN
PUF3
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 793
ILE A 794
GLU A 767
VAL A 778
ILE A 782
 None
 1.48A 6hloA-3k49A:
undetectable		 6hloA-3k49A:
19.70