SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 9 ILE A  74
LEU A  11
GLU A 263
ALA A 257
VAL A  96
 None
 1.06A 1ctrA-3k4hA:
undetectable		 1ctrA-3k4hA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 4 ILE A 137
MET A 187
VAL A 218
GLY A 179
 None
 1.42A 1e06B-3k4hA:
undetectable		 1e06B-3k4hA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 7 PHE A 174
ASN A  25
PHE A  28
SER A  17
 MAL  A 501 (-3.0A)
MAL  A 501 (-3.9A)
MAL  A 501 (-4.6A)
None
 1.33A 1rqpB-3k4hA:
3.5		 1rqpB-3k4hA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 7 MET A 197
PHE A 136
ARG A 147
ASN A 115
 None
None
None
MAL  A 501 (-3.1A)
 1.17A 1t9wA-3k4hA:
undetectable		 1t9wA-3k4hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 7 PHE A 174
ASN A  25
PHE A  28
SER A  17
 MAL  A 501 (-3.0A)
MAL  A 501 (-3.9A)
MAL  A 501 (-4.6A)
None
 1.34A 2v7uB-3k4hA:
2.9		 2v7uB-3k4hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 6 LEU A 202
ALA A 230
LEU A 240
ALA A 236
 None
 0.98A 2vcvB-3k4hA:
undetectable		 2vcvB-3k4hA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 7 ALA A 135
ILE A 169
ILE A 137
HIS A 171
 None
 1.06A 2zm7A-3k4hA:
undetectable		 2zm7A-3k4hA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		6 / 10 LEU A  13
GLY A 251
ALA A 254
VAL A  96
GLY A  99
ILE A  74
 None
None
None
None
MAL  A 501 (-3.3A)
None
 1.48A 3ekpD-3k4hA:
undetectable		 3ekpD-3k4hA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 12 LEU A 211
ASP A 221
VAL A 218
HIS A 131
HIS A 287
 None
 1.35A 3hgiA-3k4hA:
undetectable		 3hgiA-3k4hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 9 LEU A  88
GLY A  99
ILE A  98
ILE A  84
ILE A  85
 None
MAL  A 501 (-3.3A)
MAL  A 501 (-4.8A)
None
None
 0.95A 3s56B-3k4hA:
undetectable		 3s56B-3k4hA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 10 ALA A 210
LEU A 211
PHE A 216
VAL A 222
ALA A 135
 None
 1.08A 4j14A-3k4hA:
undetectable		 4j14A-3k4hA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 12 GLY A 204
GLY A 179
SER A 175
ILE A 196
ALA A 198
 None
 0.94A 4qtuB-3k4hA:
2.5		 4qtuB-3k4hA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 12 GLY A 204
GLY A 179
SER A 175
ILE A 196
ALA A 198
 None
 0.90A 4qtuD-3k4hA:
undetectable		 4qtuD-3k4hA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		4 / 6 ILE A 134
HIS A 171
ILE A 203
VAL A 207
 None
 0.90A 4zj8A-3k4hA:
5.9		 4zj8A-3k4hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 7 VAL A  14
ILE A  73
PHE A  93
VAL A  61
ILE A  57
 None
 1.43A 5bmvC-3k4hA:
undetectable		 5bmvC-3k4hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 11 ILE A  35
GLY A 251
ALA A 255
LEU A  11
VAL A 259
 None
 1.29A 5hw4B-3k4hA:
2.8		 5hw4B-3k4hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 11 LEU A 170
ALA A 182
GLU A 185
LEU A 189
LEU A 211
 None
 1.49A 5hyrB-3k4hA:
undetectable		 5hyrB-3k4hA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		3 / 3 THR A 117
HIS A 276
ASN A 113
 None
None
MAL  A 501 (-3.4A)
 0.69A 5n4tA-3k4hA:
undetectable		 5n4tA-3k4hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 10 LEU A 170
ILE A 137
GLY A 138
GLY A 140
ALA A 182
 None
 1.02A 5o96C-3k4hA:
undetectable
5o96D-3k4hA:
2.6		 5o96C-3k4hA:
22.30
5o96D-3k4hA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 12 LEU A  13
GLY A 251
ALA A 254
GLY A  99
ILE A  74
 None
None
None
MAL  A 501 (-3.3A)
None
 1.06A 5t2zA-3k4hA:
undetectable		 5t2zA-3k4hA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3k4h PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Bacillus
cytotoxicus) 		5 / 12 LEU A 164
ALA A 119
ALA A 198
ILE A 203
GLY A 139
 None
 1.07A 5veuB-3k4hA:
undetectable		 5veuB-3k4hA:
22.20