SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ASP A 174
PRO A 134
TYR A 133
THR A 116
SER A  85
 None
 1.19A 1xoqA-3k4iA:
undetectable		 1xoqA-3k4iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ASP A 174
PRO A 134
TYR A 133
THR A 116
SER A  85
 None
 1.18A 1xoqB-3k4iA:
undetectable		 1xoqB-3k4iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 MET A 104
VAL A 128
THR A 127
ARG A 123
 CL  A 502 (-3.7A)
None
None
None
 1.24A 2kotA-3k4iA:
undetectable		 2kotA-3k4iA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 TYR A  77
GLN A  80
VAL A  81
PRO A  82
ILE A 103
 None
None
None
None
CL  A 502 (-4.1A)
 1.32A 3ganA-3k4iA:
undetectable		 3ganA-3k4iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 ALA A 122
ARG A 140
ILE A 118
GLY A 120
LEU A 135
 None
 1.11A 3kw2A-3k4iA:
undetectable		 3kw2A-3k4iA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ILE A  56
LEU A  17
ALA A 186
ALA A 187
 None
 0.81A 3r9tB-3k4iA:
undetectable		 3r9tB-3k4iA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A 116
TRP A 100
TYR A  77
TYR A 133
 None
 0.98A 4a3uA-3k4iA:
undetectable		 4a3uA-3k4iA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A 116
TRP A 100
TYR A  77
TYR A 133
 None
 0.98A 4a3uB-3k4iA:
undetectable		 4a3uB-3k4iA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ILE A 163
GLY A 162
CYH A 178
ASP A 119
 None
 1.03A 5hieA-3k4iA:
undetectable		 5hieA-3k4iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3k4i UNCHARACTERIZED
PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 LYS A 152
SER A  90
PRO A 157
ILE A 165
 None
 1.14A 5jhdE-3k4iA:
undetectable
5jhdG-3k4iA:
undetectable		 5jhdE-3k4iA:
23.05
5jhdG-3k4iA:
15.57