SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 7 GLY A  90
ALA A 124
THR A 185
THR A  71
 None
None
None
LYS  A 501 (-4.2A)
 0.85A 1c9sT-3k4uA:
undetectable
1c9sU-3k4uA:
undetectable		 1c9sT-3k4uA:
19.60
1c9sU-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 LEU A 208
LEU A   5
LEU A  32
VAL A  83
ILE A  65
 None
 1.21A 1ee2A-3k4uA:
undetectable		 1ee2A-3k4uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 LEU A 208
LEU A   5
LEU A  32
VAL A  83
ILE A  65
 None
 1.19A 1ee2B-3k4uA:
undetectable		 1ee2B-3k4uA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		6 / 12 MET A  40
VAL A  42
VAL A   7
ALA A  33
ILE A  65
ILE A 193
 None
 1.28A 1epbA-3k4uA:
undetectable		 1epbA-3k4uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		3 / 3 GLU A 143
TYR A  13
PHE A 160
 LYS  A 501 (-3.5A)
LYS  A 501 (-4.3A)
LYS  A 501 (-4.6A)
 0.81A 1eqbB-3k4uA:
undetectable		 1eqbB-3k4uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		3 / 3 GLU A 143
TYR A  13
PHE A 160
 LYS  A 501 (-3.5A)
LYS  A 501 (-4.3A)
LYS  A 501 (-4.6A)
 0.80A 1eqbA-3k4uA:
undetectable		 1eqbA-3k4uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		3 / 3 GLU A 143
TYR A  13
PHE A 160
 LYS  A 501 (-3.5A)
LYS  A 501 (-4.3A)
LYS  A 501 (-4.6A)
 0.81A 1eqbD-3k4uA:
undetectable		 1eqbD-3k4uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		3 / 3 GLU A 143
TYR A  13
PHE A 160
 LYS  A 501 (-3.5A)
LYS  A 501 (-4.3A)
LYS  A 501 (-4.6A)
 0.81A 1eqbC-3k4uA:
undetectable		 1eqbC-3k4uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 7 GLY A  90
ALA A 124
THR A 185
THR A  71
 None
None
None
LYS  A 501 (-4.2A)
 0.85A 1gtfL-3k4uA:
undetectable
1gtfM-3k4uA:
undetectable		 1gtfL-3k4uA:
19.60
1gtfM-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 GLY A  90
ALA A 124
THR A 185
THR A  71
 None
None
None
LYS  A 501 (-4.2A)
 0.82A 1gtfN-3k4uA:
undetectable
1gtfO-3k4uA:
undetectable		 1gtfN-3k4uA:
19.60
1gtfO-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 12 LEU A 204
ALA A  33
LEU A  44
LEU A   1
ILE A 193
 None
 0.89A 1s9pD-3k4uA:
undetectable		 1s9pD-3k4uA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 GLY A  90
SER A 183
HIS A 179
ILE A 159
ALA A 124
 None
 1.19A 2a58A-3k4uA:
2.7
2a58E-3k4uA:
3.0		 2a58A-3k4uA:
20.82
2a58E-3k4uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 12 ILE A 159
ALA A 124
GLY A  90
SER A 183
HIS A 179
 None
 1.19A 2a58A-3k4uA:
3.0
2a58B-3k4uA:
3.1		 2a58A-3k4uA:
20.82
2a58B-3k4uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 12 ILE A 159
ALA A 124
GLY A  90
SER A 183
HIS A 179
 None
 1.20A 2a58B-3k4uA:
3.0
2a58C-3k4uA:
3.0		 2a58B-3k4uA:
20.82
2a58C-3k4uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 ILE A 159
ALA A 124
GLY A  90
SER A 183
HIS A 179
 None
 1.18A 2a58C-3k4uA:
2.5
2a58D-3k4uA:
2.8		 2a58C-3k4uA:
20.82
2a58D-3k4uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 12 ILE A 159
ALA A 124
GLY A  90
SER A 183
HIS A 179
 None
 1.19A 2a58D-3k4uA:
3.0
2a58E-3k4uA:
2.9		 2a58D-3k4uA:
20.82
2a58E-3k4uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.29A 2dg3A-3k4uA:
undetectable		 2dg3A-3k4uA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.26A 2dg4A-3k4uA:
undetectable		 2dg4A-3k4uA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 12 ALA A  33
GLY A  27
ILE A  26
PRO A  48
VAL A   7
 None
 0.99A 2nnkA-3k4uA:
undetectable		 2nnkA-3k4uA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		3 / 3 ARG A  79
ILE A  72
THR A 185
 None
 0.73A 3ia4D-3k4uA:
undetectable		 3ia4D-3k4uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 11 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.26A 4drjA-3k4uA:
undetectable		 4drjA-3k4uA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 10 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.28A 4qt2A-3k4uA:
undetectable		 4qt2A-3k4uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		5 / 10 GLU A 187
VAL A  89
ILE A  87
TYR A  86
PHE A 225
 None
 1.30A 4qt3A-3k4uA:
undetectable		 4qt3A-3k4uA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 5 LEU A  32
ASP A  29
TYR A 217
LEU A 220
 None
 1.27A 4wozF-3k4uA:
undetectable
4wozH-3k4uA:
undetectable		 4wozF-3k4uA:
22.11
4wozH-3k4uA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5eevL-3k4uA:
undetectable
5eevV-3k4uA:
undetectable		 5eevL-3k4uA:
19.60
5eevV-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5eewL-3k4uA:
undetectable
5eewV-3k4uA:
undetectable		 5eewL-3k4uA:
19.60
5eewV-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5eezL-3k4uA:
undetectable
5eezV-3k4uA:
undetectable		 5eezL-3k4uA:
19.60
5eezV-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5ef1L-3k4uA:
undetectable
5ef1V-3k4uA:
undetectable		 5ef1L-3k4uA:
19.60
5ef1V-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5ef2L-3k4uA:
undetectable
5ef2V-3k4uA:
undetectable		 5ef2L-3k4uA:
19.60
5ef2V-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3k4u BINDING COMPONENT OF
ABC TRANSPORTER
(Wolinella
succinogenes) 		4 / 8 THR A  71
GLY A  90
ALA A 124
THR A 185
 LYS  A 501 (-4.2A)
None
None
None
 0.84A 5ef3L-3k4uA:
undetectable
5ef3V-3k4uA:
undetectable		 5ef3L-3k4uA:
19.60
5ef3V-3k4uA:
19.60