SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A  54
PRO A  61
VAL A  62
ILE A  86
 IPE  A 300 (-2.9A)
None
None
None
 0.94A 2aoiA-3k4yA:
undetectable		 2aoiA-3k4yA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A   7
PHE A  93
ALA A  57
GLY A  54
ILE A  29
THR A 100
 None
None
None
IPE  A 300 (-2.9A)
None
None
 1.39A 3c6gA-3k4yA:
undetectable		 3c6gA-3k4yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  54
GLY A  55
GLY A  59
HIS A  60
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
IPE  A 300 (-3.1A)
 0.29A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  54
GLY A  55
GLY A  59
ILE A  86
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
None
 0.67A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A  97
GLN A 102
ILE A  29
LEU A 138
 None
 1.30A 3dzyD-3k4yA:
undetectable		 3dzyD-3k4yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 157
PHE A 125
HIS A  53
 None
 0.68A 3h0aA-3k4yA:
undetectable		 3h0aA-3k4yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  97
LEU A  26
ILE A  29
ALA A  30
ILE A 142
 None
 0.88A 3vrmA-3k4yA:
undetectable		 3vrmA-3k4yA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 142
LEU A 123
ASP A 160
GLY A 159
TYR A 220
 None
None
SO4  A 262 ( 4.4A)
IPE  A 300 (-3.4A)
None
 1.31A 4foxF-3k4yA:
undetectable		 4foxF-3k4yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  54
GLY A  55
GLY A  56
SER A  10
HIS A 143
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-3.4A)
None
None
 1.01A 4htfB-3k4yA:
3.2		 4htfB-3k4yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 180
VAL A 181
GLY A   9
GLY A 217
ASP A 160
 None
None
SO4  A 262 (-3.2A)
None
SO4  A 262 ( 4.4A)
 1.16A 4pevB-3k4yA:
4.9		 4pevB-3k4yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A   7
LEU A  51
THR A   3
LEU A  49
LEU A 247
 None
 1.04A 4z91A-3k4yA:
1.6
4z91B-3k4yA:
1.7
4z91C-3k4yA:
undetectable
4z91D-3k4yA:
undetectable
4z91E-3k4yA:
undetectable		 4z91A-3k4yA:
19.94
4z91B-3k4yA:
19.94
4z91C-3k4yA:
19.94
4z91D-3k4yA:
19.94
4z91E-3k4yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A   3
LEU A  49
LEU A 247
LEU A   7
LEU A  51
 None
 1.05A 4z91A-3k4yA:
1.6
4z91B-3k4yA:
1.7
4z91C-3k4yA:
undetectable
4z91D-3k4yA:
undetectable
4z91E-3k4yA:
undetectable		 4z91A-3k4yA:
19.94
4z91B-3k4yA:
19.94
4z91C-3k4yA:
19.94
4z91D-3k4yA:
19.94
4z91E-3k4yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A   7
ILE A  29
ALA A  30
ALA A 108
 None
 0.69A 4zf8A-3k4yA:
undetectable		 4zf8A-3k4yA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 251
LEU A   5
ILE A 243
THR A 179
 None
None
None
SO4  A 262 (-4.3A)
 0.79A 4zf8A-3k4yA:
undetectable		 4zf8A-3k4yA:
20.93