SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 112
TRP A 118
LYS A 177
 XGP  A 295 ( 4.8A)
None
None
 1.02A 1qu2A-3k4zA:
undetectable		 1qu2A-3k4zA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A 131
LEU A  89
THR A 124
LEU A 123
 None
 0.88A 1v55N-3k4zA:
undetectable
1v55W-3k4zA:
undetectable		 1v55N-3k4zA:
17.89
1v55W-3k4zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 259
HIS A 273
PRO A 274
TYR A 271
 None
 1.01A 2ombC-3k4zA:
5.6
2ombD-3k4zA:
5.4		 2ombC-3k4zA:
24.73
2ombD-3k4zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 241
ASN A 208
THR A 264
 None
 0.74A 2q63B-3k4zA:
undetectable		 2q63B-3k4zA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 4 TYR A  85
LEU A  77
LEU A  16
HIS A  83
 None
None
None
NI  A 292 ( 3.4A)
 1.17A 2x7hB-3k4zA:
undetectable		 2x7hB-3k4zA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.24A 3ko0A-3k4zA:
undetectable
3ko0B-3k4zA:
undetectable
3ko0C-3k4zA:
undetectable
3ko0D-3k4zA:
undetectable		 3ko0A-3k4zA:
16.07
3ko0B-3k4zA:
16.07
3ko0C-3k4zA:
16.07
3ko0D-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  79
ASP A 142
LEU A 170
PHE A 147
ILE A 103
 None
 1.18A 3ko0A-3k4zA:
undetectable
3ko0B-3k4zA:
undetectable
3ko0I-3k4zA:
undetectable
3ko0J-3k4zA:
undetectable		 3ko0A-3k4zA:
16.07
3ko0B-3k4zA:
16.07
3ko0I-3k4zA:
16.07
3ko0J-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.20A 3ko0K-3k4zA:
undetectable
3ko0L-3k4zA:
undetectable
3ko0S-3k4zA:
undetectable
3ko0T-3k4zA:
undetectable		 3ko0K-3k4zA:
16.07
3ko0L-3k4zA:
16.07
3ko0S-3k4zA:
16.07
3ko0T-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A  79
ASP A 142
LEU A 170
PHE A 147
ILE A 103
 None
 1.22A 3ko0K-3k4zA:
undetectable
3ko0L-3k4zA:
undetectable
3ko0M-3k4zA:
undetectable
3ko0N-3k4zA:
undetectable		 3ko0K-3k4zA:
16.07
3ko0L-3k4zA:
16.07
3ko0M-3k4zA:
16.07
3ko0N-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 170
PHE A 147
ILE A 103
LEU A  79
ASP A 142
 None
 1.19A 3ko0M-3k4zA:
undetectable
3ko0N-3k4zA:
undetectable
3ko0O-3k4zA:
undetectable
3ko0P-3k4zA:
undetectable		 3ko0M-3k4zA:
16.07
3ko0N-3k4zA:
16.07
3ko0O-3k4zA:
16.07
3ko0P-3k4zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A  92
ALA A 125
VAL A 128
 None
 1.02A 3l8lA-3k4zA:
undetectable
3l8lB-3k4zA:
undetectable		 3l8lA-3k4zA:
17.86
3l8lB-3k4zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 100
ILE A  91
GLU A 154
GLU A 112
VAL A 163
 None
None
None
XGP  A 295 ( 4.8A)
None
 1.21A 4a97A-3k4zA:
0.1
4a97B-3k4zA:
0.0		 4a97A-3k4zA:
20.68
4a97B-3k4zA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 195
LEU A 246
VAL A 188
VAL A 190
 None
 0.92A 4em2A-3k4zA:
undetectable		 4em2A-3k4zA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 THR A   8
ASP A 166
GLU A  19
 None
MG  A 290 (-2.6A)
MG  A 291 (-2.6A)
 0.78A 5fa8A-3k4zA:
undetectable		 5fa8A-3k4zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 100
THR A 148
ARG A  73
GLN A  71
 None
None
CBI  A 294 (-3.2A)
CBI  A 294 (-3.0A)
 1.36A 5tzoC-3k4zA:
undetectable		 5tzoC-3k4zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 171
ARG A  86
THR A  84
 None
 0.99A 5z84J-3k4zA:
undetectable		 5z84J-3k4zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A  54
VAL A  44
ASP A  46
 None
 0.44A 6fgdA-3k4zA:
undetectable		 6fgdA-3k4zA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3k4z GLYCOSIDE HYDROLASE
FAMILY 9
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ILE A 131
LEU A  89
THR A 124
LEU A 123
 None
 0.90A 6nmpN-3k4zA:
undetectable
6nmpW-3k4zA:
undetectable		 6nmpN-3k4zA:
17.89
6nmpW-3k4zA:
12.46