SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		3 / 3 ASP A 231
THR A 195
PRO A 196
 None
 0.70A 2pynB-3k53A:
undetectable		 2pynB-3k53A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 ILE A 131
PHE A 119
ILE A  88
ASN A  97
LEU A  94
 None
 1.14A 2rlcA-3k53A:
undetectable		 2rlcA-3k53A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 11 LEU A  57
VAL A   9
GLY A  10
ILE A  72
ALA A  73
 None
 0.92A 2yy8A-3k53A:
2.1
2yy8B-3k53A:
undetectable		 2yy8A-3k53A:
23.38
2yy8B-3k53A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		4 / 8 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.78A 3fi0B-3k53A:
undetectable		 3fi0B-3k53A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		4 / 7 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.80A 3fi0E-3k53A:
undetectable		 3fi0E-3k53A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		4 / 8 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.73A 3fi0G-3k53A:
undetectable		 3fi0G-3k53A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		4 / 8 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.81A 3fi0I-3k53A:
undetectable		 3fi0I-3k53A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		4 / 8 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.76A 3fi0Q-3k53A:
undetectable		 3fi0Q-3k53A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 THR A 170
VAL A  84
LEU A   8
ILE A  19
THR A 145
 None
 1.13A 3frqA-3k53A:
undetectable		 3frqA-3k53A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 ILE A  88
LEU A   8
VAL A   6
LEU A 156
ALA A 161
 None
 1.34A 3ozuA-3k53A:
2.7		 3ozuA-3k53A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		3 / 3 PRO A  58
ASP A  56
GLU A  39
 None
 0.78A 3v4tC-3k53A:
undetectable		 3v4tC-3k53A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		6 / 11 ALA A   7
ILE A  88
GLY A  10
ILE A  60
VAL A 109
ILE A  85
 None
 1.20A 4qgiB-3k53A:
undetectable		 4qgiB-3k53A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.96A 4x1kD-3k53A:
undetectable		 4x1kD-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.93A 4x1yD-3k53A:
2.9		 4x1yD-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 11 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.93A 4x20D-3k53A:
4.6		 4x20D-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 LEU A 240
LYS A 243
VAL A 251
TYR A 177
LEU A 211
 None
 1.26A 5cymA-3k53A:
undetectable		 5cymA-3k53A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 LEU A 240
LYS A 243
VAL A 251
TYR A 177
LEU A 211
 None
 1.26A 5cyqA-3k53A:
undetectable		 5cyqA-3k53A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.26A 5eypB-3k53A:
2.7		 5eypB-3k53A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.30A 5nm5B-3k53A:
2.8		 5nm5B-3k53A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		3 / 3 MET A 107
GLU A  70
ARG A  74
 None
 0.74A 5tjyA-3k53A:
7.7		 5tjyA-3k53A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		3 / 3 MET A 107
GLU A  70
ARG A  74
 None
 0.80A 5tjzA-3k53A:
7.4		 5tjzA-3k53A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 10 ILE A  19
ASN A 117
ILE A 113
ILE A 112
LEU A 104
 None
 1.41A 5vkqC-3k53A:
2.3
5vkqD-3k53A:
2.3		 5vkqC-3k53A:
10.11
5vkqD-3k53A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3k53 FERROUS IRON
TRANSPORT PROTEIN B
(Pyrococcus
furiosus) 		5 / 12 LEU A  63
ASN A  81
THR A   5
ALA A   7
ILE A  85
 None
 1.31A 5xiwD-3k53A:
2.9		 5xiwD-3k53A:
13.28