SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 LEU A 128
PHE A  67
TYR A 169
VAL A  54
 None
None
GOL  A 187 ( 4.9A)
None
 1.21A 1ibgH-3k5jA:
undetectable		 1ibgH-3k5jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 10 LEU A  34
GLN A  60
GLY A  59
LEU A  62
PHE A  37
 None
SO4  A 183 (-3.1A)
None
None
None
 1.34A 2ok6A-3k5jA:
2.5
2ok6H-3k5jA:
undetectable		 2ok6A-3k5jA:
18.64
2ok6H-3k5jA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 7 TYR A 124
GLU A  49
TRP A  15
LEU A 128
 None
 1.15A 3k8mB-3k5jA:
undetectable		 3k8mB-3k5jA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 PHE A 116
TYR A  53
LEU A 120
 None
 0.78A 3keeB-3k5jA:
undetectable		 3keeB-3k5jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 PHE A 116
TYR A  53
LEU A 120
 None
 0.79A 3sueB-3k5jA:
undetectable		 3sueB-3k5jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 GLY A  57
ILE A  58
VAL A   7
SER A  55
 None
 1.22A 4d33A-3k5jA:
undetectable		 4d33A-3k5jA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 GLY A  57
ILE A  58
VAL A   7
SER A  55
 None
 1.21A 4d33B-3k5jA:
undetectable		 4d33B-3k5jA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 SER A  70
GLU A  76
GLU A 109
GLY A 104
 None
 0.93A 4fgzA-3k5jA:
undetectable
4fgzB-3k5jA:
undetectable		 4fgzA-3k5jA:
19.62
4fgzB-3k5jA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 GLU A 146
LEU A 158
ARG A 174
ILE A 118
GLY A  98
 None
 1.04A 4j26A-3k5jA:
undetectable		 4j26A-3k5jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 TRP A  51
GLN A 110
THR A  74
 None
 1.03A 4m2xA-3k5jA:
undetectable		 4m2xA-3k5jA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		4 / 8 SER A  70
HIS A  77
ILE A 172
GLU A  76
 None
 0.99A 4ms4A-3k5jA:
undetectable		 4ms4A-3k5jA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 167
LEU A 140
GLU A 164
PHE A 162
GLY A 166
 None
 1.37A 5il1A-3k5jA:
undetectable		 5il1A-3k5jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 167
LEU A 140
GLU A 164
PHE A 162
GLY A 166
 None
 1.36A 5k7uA-3k5jA:
undetectable		 5k7uA-3k5jA:
23.08