SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 6 GLY A 168
GLY A 190
TYR A 189
SER A 173
 None
 0.89A 1eswA-3k5pA:
undetectable		 1eswA-3k5pA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A 234
LEU A 227
ILE A 264
LEU A 282
PRO A 281
 EDO  A 413 ( 4.3A)
None
None
None
None
 0.87A 1rx8A-3k5pA:
undetectable		 1rx8A-3k5pA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 LEU A  66
LEU A  17
LEU A  16
LEU A  48
 None
 1.16A 1yajD-3k5pA:
3.2		 1yajD-3k5pA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A 234
LEU A 227
ILE A 264
LEU A 282
PRO A 281
 EDO  A 413 ( 4.3A)
None
None
None
None
 0.88A 2d0kA-3k5pA:
undetectable		 2d0kA-3k5pA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 ARG A  98
PHE A  71
LEU A  48
ALA A  74
 None
 1.37A 2e1qD-3k5pA:
undetectable		 2e1qD-3k5pA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 6 PRO A 335
LEU A 411
ARG A 336
GLY A 339
 GOL  A 416 ( 4.8A)
None
None
GOL  A 416 (-4.5A)
 1.21A 2hs2B-3k5pA:
undetectable		 2hs2B-3k5pA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 8 GLN A 330
PHE A 103
GLY A 324
GLY A  99
 None
 0.93A 2y6rB-3k5pA:
4.2		 2y6rB-3k5pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 ASN A 274
THR A  64
SER A  62
SER A  84
 None
 1.44A 3hlwB-3k5pA:
undetectable		 3hlwB-3k5pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 1.00A 3twpA-3k5pA:
2.7		 3twpA-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 0.98A 3twpB-3k5pA:
2.4		 3twpB-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 0.98A 3twpC-3k5pA:
2.7		 3twpC-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 ASN A 327
ALA A 325
TYR A 316
ALA A  79
 None
 1.01A 3twpD-3k5pA:
undetectable		 3twpD-3k5pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 VAL A 395
LEU A 396
SER A 392
MET A 343
 None
 1.36A 4e1gA-3k5pA:
undetectable		 4e1gA-3k5pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		3 / 3 LYS A   8
TYR A  33
ARG A   9
 None
 1.26A 4gc9A-3k5pA:
3.4		 4gc9A-3k5pA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 LEU A  43
LYS A  45
GLN A  65
LEU A  66
 None
 0.96A 4ib4A-3k5pA:
undetectable		 4ib4A-3k5pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		3 / 3 ARG A  96
LYS A  97
LYS A  93
 None
 1.22A 4k50A-3k5pA:
undetectable		 4k50A-3k5pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		3 / 3 ARG A  96
LYS A  97
LYS A  93
 None
 1.29A 4k50I-3k5pA:
undetectable		 4k50I-3k5pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ASP A 318
ILE A 100
GLY A  99
SER A 321
PHE A 328
 None
 1.16A 4obwC-3k5pA:
5.1		 4obwC-3k5pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 8 ILE A  20
PHE A  28
LEU A  16
LEU A 313
 None
 0.93A 4qopC-3k5pA:
undetectable		 4qopC-3k5pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 11 ILE A 294
SER A 297
GLY A 296
ASP A 265
THR A 291
 None
 0.93A 4xt7A-3k5pA:
2.7		 4xt7A-3k5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A 294
SER A 297
GLY A 296
ASP A 265
THR A 291
 None
 0.94A 4xt8A-3k5pA:
undetectable		 4xt8A-3k5pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 10 GLY A 159
VAL A 158
THR A 183
VAL A 212
LEU A 221
 GOL  A 414 ( 4.3A)
GOL  A 414 ( 4.7A)
GOL  A 414 (-3.5A)
GOL  A 414 (-3.9A)
None
 1.04A 4yb6A-3k5pA:
6.3
4yb6E-3k5pA:
6.1		 4yb6A-3k5pA:
21.80
4yb6E-3k5pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 10 GLY A 159
VAL A 158
THR A 183
VAL A 212
LEU A 221
 GOL  A 414 ( 4.3A)
GOL  A 414 ( 4.7A)
GOL  A 414 (-3.5A)
GOL  A 414 (-3.9A)
None
 1.04A 4yb6B-3k5pA:
4.7
4yb6C-3k5pA:
6.1		 4yb6B-3k5pA:
21.80
4yb6C-3k5pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 10 LEU A 221
GLY A 159
VAL A 158
THR A 183
VAL A 212
 None
GOL  A 414 ( 4.3A)
GOL  A 414 ( 4.7A)
GOL  A 414 (-3.5A)
GOL  A 414 (-3.9A)
 1.05A 4yb6B-3k5pA:
4.7
4yb6F-3k5pA:
6.1		 4yb6B-3k5pA:
21.80
4yb6F-3k5pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 VAL A 158
LEU A 198
SER A 197
GLU A 200
 GOL  A 414 ( 4.7A)
None
None
None
 1.03A 4zphA-3k5pA:
undetectable
4zphB-3k5pA:
undetectable		 4zphA-3k5pA:
22.30
4zphB-3k5pA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A 325
ILE A 100
GLY A  99
ASP A 375
LEU A  92
 None
 1.20A 5nfjB-3k5pA:
undetectable		 5nfjB-3k5pA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A 325
ILE A 100
GLY A  99
ASP A 375
LEU A  92
 None
 1.20A 5nfjC-3k5pA:
undetectable		 5nfjC-3k5pA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 VAL A 158
VAL A 208
ILE A 222
ASP A 244
 GOL  A 414 ( 4.7A)
None
None
None
 0.89A 5yf9B-3k5pA:
2.2		 5yf9B-3k5pA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Brucella
abortus) 		6 / 12 ALA A  51
LEU A  48
ALA A  74
ILE A  20
HIS A  38
LEU A  39
 None
 1.40A 6a60D-3k5pA:
undetectable		 6a60D-3k5pA:
15.04