SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3k5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 10 ALA A 440
PHE A 259
LEU A 383
VAL A 338
ILE A 391
 None
 1.31A 1claA-3k5wA:
undetectable		 1claA-3k5wA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 ALA A  30
SER A 125
ILE A 152
LEU A 182
TYR A 206
 None
 1.24A 1dlsA-3k5wA:
undetectable		 1dlsA-3k5wA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 ALA A 440
LEU A 220
LEU A 215
LEU A 423
 None
 0.97A 1ereE-3k5wA:
undetectable		 1ereE-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 GLU A 281
LEU A 257
LEU A 254
HIS A 239
 None
 0.93A 1ereE-3k5wA:
undetectable		 1ereE-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 ALA A 440
LEU A 220
LEU A 215
LEU A 423
 None
 0.97A 1ereF-3k5wA:
undetectable		 1ereF-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 GLU A 281
LEU A 257
LEU A 254
HIS A 239
 None
 0.91A 1ereF-3k5wA:
undetectable		 1ereF-3k5wA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 11 LEU A 457
SER A 258
VAL A 264
LEU A 282
LEU A 251
 None
 1.12A 1mx1B-3k5wA:
undetectable		 1mx1B-3k5wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 LEU A 457
SER A 258
VAL A 264
LEU A 282
LEU A 251
 None
 1.08A 1mx1C-3k5wA:
undetectable		 1mx1C-3k5wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 9 GLU A  28
LEU A  39
ARG A  66
ALA A  65
ALA A  31
 None
 1.45A 2bxcB-3k5wA:
1.0		 2bxcB-3k5wA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 6 LEU A  51
MET A  27
MET A 175
LEU A  34
 None
 1.20A 2oz7A-3k5wA:
undetectable		 2oz7A-3k5wA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 6 LEU A 383
ALA A 437
LEU A 439
ALA A 442
 None
 0.93A 2vcvK-3k5wA:
undetectable		 2vcvK-3k5wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		3 / 3 SER A 425
GLY A 262
GLY A 260
 None
 0.55A 3bogA-3k5wA:
undetectable
3bogC-3k5wA:
undetectable		 3bogA-3k5wA:
undetectable
3bogC-3k5wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 11 LEU A 423
LEU A 416
ALA A 437
ASN A 400
VAL A 338
 None
 1.21A 3e22B-3k5wA:
3.0		 3e22B-3k5wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 11 LEU A 423
LEU A 416
ALA A 437
ASN A 400
VAL A 338
 None
 1.20A 3e22D-3k5wA:
2.8		 3e22D-3k5wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 6 GLY A 243
GLU A 270
GLU A 302
GLU A 328
 None
 0.80A 3fpjA-3k5wA:
3.6		 3fpjA-3k5wA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 10 ILE A 420
SER A 252
GLY A 418
LEU A 424
SER A 425
 None
 1.28A 3ik6B-3k5wA:
undetectable
3ik6E-3k5wA:
undetectable		 3ik6B-3k5wA:
20.09
3ik6E-3k5wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 SER A 125
ASP A  12
LEU A 199
ASP A  56
 None
 1.18A 3n2oC-3k5wA:
2.5
3n2oD-3k5wA:
3.8		 3n2oC-3k5wA:
22.53
3n2oD-3k5wA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 GLY A  45
GLY A  70
GLN A  40
VAL A  38
ALA A  37
 None
 1.25A 3t7vA-3k5wA:
undetectable		 3t7vA-3k5wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 ASP A 120
GLY A 124
GLY A 155
SER A 154
GLY A  61
 None
PO4  A 501 (-3.4A)
None
None
None
 1.04A 4blvB-3k5wA:
undetectable		 4blvB-3k5wA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		3 / 3 ARG A  93
ASP A  56
ASP A 151
 None
 0.91A 4kicB-3k5wA:
5.5		 4kicB-3k5wA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 4 ILE A 178
SER A 180
ASP A 151
ASP A  56
 None
 1.44A 4krhB-3k5wA:
5.4		 4krhB-3k5wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 8 GLY A 155
ILE A 123
GLU A 132
LEU A 135
 None
PO4  A 501 (-4.7A)
None
None
 0.81A 4mwzB-3k5wA:
undetectable		 4mwzB-3k5wA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 LEU A 183
ILE A 401
ALA A 149
ILE A 152
VAL A 191
 None
 0.83A 4nkxC-3k5wA:
undetectable		 4nkxC-3k5wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 LEU A 183
ILE A 401
ALA A 149
ILE A 152
VAL A 191
 None
 0.82A 4nkxD-3k5wA:
undetectable		 4nkxD-3k5wA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 10 LEU A 241
ALA A 296
SER A 261
LEU A 257
ALA A 256
 None
 1.21A 4zbrA-3k5wA:
undetectable		 4zbrA-3k5wA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 5 ARG A  66
ARG A  93
LEU A 199
MET A 175
 None
 1.30A 5tuiB-3k5wA:
3.0		 5tuiB-3k5wA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 ALA A  65
LEU A  34
ILE A 148
VAL A  48
CYH A 115
 None
 1.42A 5vlmE-3k5wA:
undetectable		 5vlmE-3k5wA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		4 / 6 GLY A  61
LEU A  68
ARG A  66
VAL A  99
 None
 0.99A 5x80A-3k5wA:
undetectable
5x80B-3k5wA:
undetectable		 5x80A-3k5wA:
16.14
5x80B-3k5wA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3k5w CARBOHYDRATE KINASE
(Helicobacter
pylori) 		5 / 12 ALA A 296
ALA A 417
ILE A 273
CYH A 271
LEU A 269
 None
 1.10A 6a5zD-3k5wA:
undetectable		 6a5zD-3k5wA:
12.65